Abstract: This invention is directed to a compound of formula (I): wherein R1, R2, R3 and L1 are as defined herein, a pharmaceutical composition comprising the compound, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma and/or chronic obstructive pulmonary disease (COPD).

Abstract: The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.

Abstract: This invention is directed to a compound of formula (I): wherein R1, R2, R3 and L1 are as defined herein, a pharmaceutical composition comprising the compound, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma and/or chronic obstructive pulmonary disease (COPD).

Abstract: The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.

Abstract: The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.

Abstract: A wash-coat (16) for use as a support for an active catalyst species (18) and a catalytic combustor component (10) incorporating such wash-coat. The wash-coat is a solid solution of alumina or alumina-based material (Al2O3-0-3 wt % La2O3) and a further oxide exhibiting a coefficient of thermal expansion that is lower than that exhibited by alumina. The further oxide may be silicon dioxide (2-30 wt % SiO2), zirconia silicate (2-30 wt % ZrSiO4), neodymium oxide (0-4 wt %), titania (Al2O3-3-40% TiO2) or alumina-based magnesium aluminate spinel (Al2O3-25 wt % MgO) in various embodiments. The active catalyst species may be palladium and a second metal in a concentration of 10-50% of the concentration of the palladium.

Abstract: A component for use in a combustion turbine (10) is provided that includes a substrate (212) and an abradable coating system (216) deposited on the substrate (212). A planar proximity sensor (250) may be deposited beneath a surface of the abradable coating system (216) having circuitry (252) configured to detect intrusion of an object (282) into the abradable coating system (216). A least one connector (52) may be provided in electrical communication with the planar proximity sensor (250) for routing a data signal from the planar proximity sensor (250) to a termination location (59). A plurality of trenches (142) may be formed at respective different depths below the surface of the abradable coating system (216) with a planar proximity sensor (250) deposited within each of the plurality of trenches (142).

Abstract: A component for use in a combustion turbine (10) is provided that includes a substrate (212) and a microelectromechanical system (MEMS) device (50, 250) affixed to the substrate (212). At least one connector (52) may be deposited in electrical communication with the MEMS device (50, 250) for routing a data signal from the MEMS device (50, 250) to a termination location (59). A barrier coating (216) may be deposited on the substrate (212) wherein the MEMS device (50, 250) is affixed beneath a surface of the barrier coating (216). A plurality of trenches (142) may be formed in the barrier coating (216) at respective different depths below the surface of the barrier coating (216) and a MEMS device (50, 250) deposited within each of the plurality of trenches (142). A monitoring system (30) is provided that may include a processing module (34) programmed for receiving data from the MEMS device (50, 250).

Abstract: A method of instrumenting a first component (210) for use in a combustion turbine engine (10) wherein the first component (210) has a surface contacted by a second component during operation of the combustion turbine engine (10). The method may include depositing an insulating layer (260) on the surface of the first component (210) and depositing a first conductive lead (232, 254) on the insulating layer (260). A piezoelectric material (230) may be deposited in electrical communication with the first conductive lead (232, 254) and a second conductive lead (236, 256) may be deposited in electrical communication with the piezoelectric material (230) and be insulated from the first conductive lead (232, 254) to form a sensor (50) for detecting pressure exerted on the surface of the first component (210) during operation of the combustion turbine engine (10).

Abstract: Aspects of the invention relate to a system for monitoring the wear of a component. A conductor can be embedded in the component at a depth from a surface of the component. In one embodiment, the conductor can be operatively connected to a power source to form an electrical circuit. The resistance across the conductor can be measured. As the component contacts a second component, the component can begin to wear. Once the wear progresses to the conductor, changes in the measured resistance can result. Thus, an operator can be alerted that the component has worn to a certain point and that service may be needed. Alternatively, impedance can be measured across the conductor. Because the dielectric permeability of the material surrounding the conductor can affect impedance, changes in impedance can occur as the surface material of the component is worn away.