Abstract: This document provides methods and materials related to genetic variations of developmental disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Autism Spectrum Disorder.

Abstract: A method of detecting tandem repeat expansions associated with a disease is provided. The method includes the steps of: detecting tandem repeat sequences comprising a repeated motif sequence in nucleic acid samples from individuals within a population of interest, simulating the length distribution of the tandem repeat sequences in the population of interest to a normal distribution if no tandem repeat sequences are detected, and detecting one or more outlier tandem repeat sequences in the tandem repeat sequences detected, wherein an outlier tandem repeat sequence has a length that is greater than that in 90% of the tandem repeat sequences detected in the population interest and occur at a frequency of less than 1% of the tandem repeat sequences detected in a control population. The method is useful for the diagnosis of disease and subsequent treatment of a diagnosed individual.

Abstract: This document provides methods and materials related to genetic variations of developmental disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Autism Spectrum Disorder.

Abstract: A method of identifying a gene or genomic mutation that is linked to causality of a neuropsychiatric disorder is provided. The method comprises identifying exons which exhibit an expression level that is at least within the 75th percentile of exon expression levels within a nucleic acid-containing sample from a mammal having a neuropsychiatric disorder; comparing the sequence of each identified exon to the sequence of a corresponding exon from a healthy control to identify rare or de novo sequence mutations within the identified exon; calculating the burden of rare or de novo mutations within the exon; and determining the correlation between expression level of the identified exon and burden of de novo or rare mutations in the exon, wherein an inverse correlation indicates that the exon gene is linked to causality of the neuropsychiatric disorder.

Abstract: This document provides methods and materials related to genetic variations of developmental disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Autism Spectrum Disorder.

Abstract: A method of identifying a gene or genomic mutation that is linked to causality of a neuropsychiatric disorder is provided. The method comprises identifying exons which exhibit an expression level that is at least within the 75th percentile of exon expression levels within a nucleic acid-containing sample from a mammal having a neuropsychiatric disorder; comparing the sequence of each identified exon to the sequence of a corresponding exon from a healthy control to identify rare or de novo sequence mutations within the identified exon; calculating the burden of rare or de novo mutations within the exon; and determining the correlation between expression level of the identified exon and burden of de novo or rare mutations in the exon, wherein an inverse correlation indicates that the exon gene is linked to causality of the neuropsychiatric disorder.

Abstract: This document provides methods and materials related to genetic variations of developmental disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Autism Spectrum Disorder.

Abstract: This document provides methods and materials related to genetic variations of developmental disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Autism Spectrum Disorder.

Abstract: Pre-packaged beverage container with built in additives compartments or enclosures for allowing consumer to customized flavors and nutritional benefits of the beverage being consumed. The beverage container may be configured with a plurality of popable, puncturable, or bursting additives enclosures. Each of the additive enclosures may be configured to be activatable by the consuming individual from the exterior of the beverage container at a period of time just before consumption. Upon activation of the enclosures, the additives are dispensed or released from the sealed enclosure into the beverage confined within the interior of the container without the need to open the container itself.

Abstract: This document provides methods and materials related to genetic variations of developmental disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Autism Spectrum Disorder.

Abstract: This document provides methods and materials related to genetic variations of developmental disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Autism Spectrum Disorder.

Abstract: This document provides methods and materials related to genetic variations of developmental disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Autism Spectrum Disorder.

Abstract: This document provides methods and materials related to genetic variations of developmental disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Autism Spectrum Disorder.

Abstract: A photo booth system including a photo booth, a management service, and a sharing system is described herein. The system is configured to capture photographs and promotional data from end users, edit the photographs, and to allow the end users to share the edited photographs on one or more sharing sites.

Abstract: A photo booth system including a photo booth and a management system for providing self-diagnostic and health reporting. In some cases, the photo booth and/or the management system may initiate a diagnostic test to determine the photo booth's operational state. In some cases, the management system may select and/or dispatch a maintenance personnel to the photo booth if the booth is experiencing an issue.

Abstract: A method of identifying a gene or genomic mutation that is linked to causality of a neuropsychiatric disorder is provided. The method comprises identifying exons which exhibit an expression level that is at least within the 75th percentile of exon expression levels within a nucleic acid-containing sample from a mammal having a neuropsychiatric disorder; comparing the sequence of each identified exon to the sequence of a corresponding exon from a healthy control to identify rare or de novo sequence mutations within the identified exon; calculating the burden of rare or de novo mutations within the exon; and determining the correlation between expression level of the identified exon and burden of de novo or rare mutations in the exon, wherein an inverse correlation indicates that the exon gene is linked to causality of the neuropsychiatric disorder.

Abstract: A photo booth system including a photo booth, a management service, and a sharing system is described herein. The system is configured to capture photographs and promotional data from end users, edit the photographs, and to allow the end users to share the edited photographs on one or more sharing sites. The system is further configured to analyze the promotional data collected at the photo booth to generate one or more metrics for a merchant.

Abstract: This document provides methods and materials related to genetic variations of developmental disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Autism Spectrum Disorder.

Abstract: This document provides methods and materials related to genetic variations of developmental disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Autism Spectrum Disorder.

Abstract: A method of assessing risk of ADHD in a human subject is provided. The method comprises the step of identifying in a nucleic acid-containing sample obtained from the human subject copy number variations associated with one or more genes selected from the group consisting of DCLK1, DCLK2, SORCS3, SORCS1, 16p11.2, ASTN2, MACROD2, CHCHD, CPLX2, ZBBX, PTPRN2 and TRIM32 wherein a determination of copy number variations associated with one or more of said genes is indicative of a risk of ADHD in the human subject.