Abstract: A device useful for delivering a predetermined treatment agent using a non-adhesive carrier for controlled regional release where the relationship between pore size, molecular weight, concentration and the like are predetermined to achieve specific predetermined time and quantity of release. The device includes a mouthguard shaped for extended contact with a substantial portion of the users mouth, such as all of the teeth and gums, for example, so as to provide treatment to a major region of the mouth as opposed to specific topical points of treatment. The mouthguard is held in position by properly fitting it to the patient, such as by softening and molding in situ. The portion of the mouthguard that is in direct contact with the region of treatment is formed from a polymeric material having a network of porous cavities that are sized to incorporate the treatment agent and release that agent over a predetermined period of time.