Patents by Inventor Stephen Shen

Stephen Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyanine Dyes
    Publication number: 20240132948
    Abstract: The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.
    Type: Application
    Filed: March 14, 2023
    Publication date: April 25, 2024
    Inventors: Stephen YUE, Gene SHEN, Wei-Chuan (David) SUN
  • Bispecific antibodies targeting immune checkpoints
    Patent number: 11939381
    Abstract: The present invention relates to bispecific antibodies that antagonize human PD-1 and agonize human CD137, and may be useful for treating solid and hematological tumors alone and in combination with chemotherapy and ionizing radiation.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: March 26, 2024
    Assignee: Eli Lilly and Company
    Inventors: Stephen J. Demarest, Yiqing Feng, Juqun Shen, Yang Shen, Stephanie Marie Truhlar
  • Methods and system for operating an engine
    Patent number: 11926308
    Abstract: Systems and methods for operating an internal combustion engine that is coupled to a power split transmission are described. In one example, the internal combustion engine is operated in a speed control mode or a torque control mode in response to a braking torque and a transmission shift command. Operating the engine in the torque control mode may allow the engine to charge a battery while a neutral transmission state is selected.
    Type: Grant
    Filed: March 7, 2022
    Date of Patent: March 12, 2024
    Assignee: Ford Global Technologies, LLC
    Inventors: Stephen Shen, William David Treharne, Carol Louise Okubo
  • Antibodies against IL-7R alpha subunit and uses thereof
    Patent number: 11919962
    Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R?). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: March 5, 2024
    Assignee: Bristol Myers-Squibb Company
    Inventors: Aaron Paul Yamniuk, Scott Ronald Brodeur, Ekaterina Deyanova, Richard Yu-Cheng Huang, Yun Wang, Alfred Robert Langish, Guodong Chen, Stephen Michael Carl, Hong Shen, Achal Mukundrao Pashine, Lin Hui Su
  • METHODS AND SYSTEM FOR OPERATING AN ENGINE
    Publication number: 20230278538
    Abstract: Systems and methods for operating an internal combustion engine that is coupled to a power split transmission are described. In one example, the internal combustion engine is operated in a speed control mode or a torque control mode in response to a braking torque and a transmission shift command. Operating the engine in the torque control mode may allow the engine to charge a battery while a neutral transmission state is selected.
    Type: Application
    Filed: March 7, 2022
    Publication date: September 7, 2023
    Inventors: Stephen Shen, William David Treharne, Carol Louise Okubo
  • Control of a hydraulic coupling system
    Patent number: 7007782
    Abstract: This invention describes a control method for a hydraulic coupling system that includes pressurizing a fluid in an actuator coupled to a multi-disk clutch pack to engage the clutch pack, pumping the fluid through the clutch pack to cool the clutch pack, and controlling one or more valve actuators and one or more pump-motors with a controller. The control method may incorporate pulse width modulation of the actuators, such as the actuators for the pump-motor and valve.
    Type: Grant
    Filed: January 14, 2004
    Date of Patent: March 7, 2006
    Assignee: Automotive Components Holdings LLC
    Inventors: Sohel Anwar, Dean T. Wisniewski, Norman Szalony, Xiaohong N. Duan, Hualin Tan, Stephen Shen, Clive McKenzie, Hyeongcheol Lee
  • Control of a hydraulic coupling system
    Publication number: 20040159520
    Abstract: This invention describes a control method for a hydraulic coupling system that includes pressurizing a fluid in an actuator coupled to a multi-disk clutch pack to engage the clutch pack, pumping the fluid through the clutch pack to cool the clutch pack, and controlling one or more valve actuators and one or more pump-motors with a controller. The control method may incorporate pulse width modulation of the actuators, such as the actuators for the pump-motor and valve.
    Type: Application
    Filed: January 14, 2004
    Publication date: August 19, 2004
    Inventors: Sohel Anwar, Dean T. Wisniewski, Norman Szalony, Xiaohong N. Duan, Hualin Tan, Stephen Shen, Clive McKenzie, Hyeongcheol Lee