Abstract: This application describes small noncoding RNA markers that can be found in a biological sample taken from an individual. The level of such markers are useful for determining the individual's health status, especially in comparison with others. Methods and kits for the use of these markers are provided as well.

Abstract: The present disclosure provides compositions and methods for using phage epitopes to profile the immune response. The phage epitopes can be used to detect one or more antibodies from a sample. Furthermore, the present disclosure provides methods and compositions for detecting a cancer based on the detection of one or more antibodies. In one embodiment, the antibody is an autoantibody. The present disclosure also provides methods of producing antibody detecting complexes.

Abstract: The present disclosure provides compositions and methods for using phage epitopes to profile the immune response. The phage epitopes can be used to detect one or more antibodies from a sample. Furthermore, the present disclosure provides methods and compositions for detecting a cancer based on the detection of one or more antibodies. In one embodiment, the antibody is an autoantibody.

Abstract: The invention is based on the discovery that the growth hormone-insulin-like growth factor-1 genetic signaling pathway and caloric restriction in conjunction extend lifespan and delay the onset of age-related diseases.

Abstract: A method of evaluating the dynamics of caloric restriction (CR). In one embodiment, a method of evaluating the dynamics of CR comprises obtaining control data from an administration of a long-term control diet program. Each of several mammalian sample groups is subjected to a CR diet program for a different amount of time. The effect of CR between each of the several mammalian sample groups and the control data are compared to each other. Additionally, the effects among members of CR among the several mammalian sample groups are compared to each other.