Abstract: The present invention provides strongly antigenic tumor-specific substances (also cellular material containing said strongly antigenic tumor-specific substances) prepared by radiofrequency or microwave electromagnetic radiation, acting on cancer tissue or cancer cells of known pathohistologic character. Said substances and also cellular material containing said substances are characterized by such sensitizing antigenic qualities that when they are contacted with a composition of naturally cancer-sensitized lymphocytes taken from a host having pathohistologically related cancer, then said lymphocytes produce and exude lymphokine.The invention further provides diagnostic tests for cancer and compositions which contain or utilize said strongly-antigenic cancer-specific substances.

Abstract: The present invention provides encapsulated antigenic tumor-specific substances prepared by extracting said antigenic tumor-specific substances in an aqueous phase and then encapsulating said aqueous phase. Said encapsulated substances are characterized by a degree of antigenic activity such that when they are contacted with a composition of naturally tumor-sensitized lymphocytes taken from a host having cancer in the presence of macrophages, macrophage fusion occurs to form at least one multinucleated giant macrophage cell. The invention further provides diagnostic tests for the determination of cancer which utilize said strongly antigenic tumor-specific substances as reagents.