Patents by Inventor Stephen T. Ayrton

Stephen T. Ayrton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR DETERMINING WHETHER A PEPTIDE COMPRISES ASPARTATE OR ISOASPARTATE
    Publication number: 20210223260
    Abstract: The invention generally relates to methods for determining whether a peptide includes aspartate or isoaspartate. In certain aspects, methods of the invention involve binding an aspartate/isoaspartate residue in a peptide with a label to produce a labeled peptide. The labeled peptide is then ionized. The ionizing process causes the label to undergo rearrangement in a gas phase at a higher rate if the label is bound to the aspartate residue as compared to if the label is bound to the isoaspartate residue. The methods of the invention then involve performing a mass spectrometry analysis to detect the rearrangement of the label, thereby determining whether the peptide includes aspartate or isoaspartate.
    Type: Application
    Filed: January 26, 2021
    Publication date: July 22, 2021
    Inventors: Stephen T. Ayrton, Robert Graham Cooks, Tawnya Flick, Da Ren
  • Method for determining whether a peptide comprises aspartate or isoaspartate
    Patent number: 10908165
    Abstract: The invention generally relates to methods for determining whether a peptide includes aspartate or isoaspartate. In certain aspects, methods of the invention involve binding an aspartate/isoaspartate residue in a peptide with a label to produce a labeled peptide. The labeled peptide is then ionized. The ionizing process causes the label to undergo rearrangement in a gas phase at a higher rate if the label is bound to the aspartate residue as compared to if the label is bound to the isoaspartate residue. The methods of the invention then involve performing a mass spectrometry analysis to detect the rearrangement of the label, thereby determining whether the peptide includes aspartate or isoaspartate.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: February 2, 2021
    Assignees: Purdue Research Foundation, AMGEN INC.
    Inventors: Stephen T. Ayrton, Robert Graham Cooks, Tawnya Flick, Da Ren
  • METHOD FOR DETERMINING WHETHER A PEPTIDE COMPRISES ASPARTATE OR ISOASPARTATE
    Publication number: 20180356426
    Abstract: The invention generally relates to methods for determining whether a peptide includes aspartate or isoaspartate. In certain aspects, methods of the invention involve binding an aspartate/isoaspartate residue in a peptide with a label to produce a labeled peptide. The labeled peptide is then ionized. The ionizing process causes the label to undergo rearrangement in a gas phase at a higher rate if the label is bound to the aspartate residue as compared to if the label is bound to the isoaspartate residue. The methods of the invention then involve performing a mass spectrometry analysis to detect the rearrangement of the label, thereby determining whether the peptide includes aspartate or isoaspartate.
    Type: Application
    Filed: June 7, 2018
    Publication date: December 13, 2018
    Applicants: Purdue Research Foundation, AMGEN
    Inventors: Stephen T. Ayrton, Robert Graham Cooks, Tawnya Flick, Da Ren