Abstract: The present disclosure provides methods for treating cancer comprising administering one or more therapeutic agents for manipulation of a target gene (e.g., protein kinase, membrane associated tyrosine/threonine 1 (PKMYT1)), wherein the cancer has a mutation in, an altered (e.g., increased or decreased) expression level and/or an altered activity of a biomarker. Provided herein are methods for identifying biomarkers of the disclosure that form a synthetic lethal pair with a target gene (e.g., PKMYT1).

Abstract: Embodiments disclosed herein include an interposer. In an embodiment, the interposer comprises a substrate with a first surface and a second surface opposite from the first surface. In an embodiment, a via is provided through the substrate, where a portion of the via extends past the second surface. In an embodiment, a first layer is over the substrate, where the first layer is an electrically insulating material. In an embodiment, a second layer is over the first layer and over the portion of the via that extends past the second surface.

Abstract: A method includes: storing attributes represented in objects, generated by sources during a time interval, into a container storing a set of attributes characterizing the first asset during the time interval; accessing a combination of attributes defining a first vulnerability in a set of vulnerabilities; identifying a subset of assets, including the first device, associated with the first vulnerability based on the combination of attributes represented in the set of attributes; calculating a vulnerability risk score, in a set of vulnerability risk scores, associated with the first vulnerability based on a quantity of devices in the subset of devices and a severity score assigned to the first vulnerability; selecting a subset of vulnerabilities, in the set of vulnerabilities, exhibiting highest vulnerability risk score; and generating a visualization indicating the subset of vulnerabilities, including the first vulnerability, and the quantity of devices associated with the first vulnerability.

Abstract: A non-transitory processor-readable medium storing code representing instructions to cause a processor to perform a process includes code to cause the processor to receive a set of indications of allowed behavior associated with an application. The processor is also caused to initiate an instance of the application within a sandbox environment. The processor is further caused to receive, from a monitor module associated with the sandbox environment, a set of indications of actual behavior of the instance of the application in response to initiating the instance of the application within the sandbox environment. The processor is also caused to send an indication associated with an anomalous behavior if at least one indication from the set of indications of actual behavior does not correspond to an indication from the set of indications of allowed behavior.

Abstract: Activated carbon (AC) produced from agglomerated purified carbonaceous product (PCP) are provided. The PCP is in particulate form, at least about 90% by volume (% v) of the particles are no greater than about 25 J.1m in diameter; the PCP has an ash content of less than about 5% m and a water content of up to about 60% m. The PCP may be used to make AC, or utilized as an additive for production of AC from other carbonaceous feedstocks.

Abstract: A container specification is received. The container specification includes a definition of an image. The image definition specifies the running of one or more prestart runtime commands. The image definition is inspected to identify whether the image definition includes specifying the running of one or more prestart runtime commands. The image is started on a host system, wherein in response to identifying that the image definition includes running one or more prestart runtime commands, the starting of the image includes running the one or more prestart runtime commands prior to the container entering a running state.

Abstract: The invention relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds of Formula (I) may inhibit the activity of papain-like protease (PLpro) and may be useful in the treatment of viral infections, in particular viral infections associated with PLpro activity and/or expression such as coronaviruses infections.

Abstract: Devices, systems and methods for solar powered water heater are provided. A solar powered water heater may comprise a pump, a heater structure and a solar panel. The heater structure in may be in communication with the pump. The solar panel may be in communication with the pump, wherein the pump is powered by the solar panel. In exemplary embodiments, the solar powered water heater floats in a pool or spa and uses solar power to drive a pump which pumps water though a heater structure before returning it to the pool or spa.

Abstract: A non-transitory processor-readable medium storing code representing instructions to cause a processor to perform a process includes code to cause the processor to receive a set of indications of allowed behavior associated with an application. The processor is also caused to initiate an instance of the application within a sandbox environment. The processor is further caused to receive, from a monitor module associated with the sandbox environment, a set of indications of actual behavior of the instance of the application in response to initiating the instance of the application within the sandbox environment. The processor is also caused to send an indication associated with an anomalous behavior if at least one indication from the set of indications of actual behavior does not correspond to an indication from the set of indications of allowed behavior.

Abstract: Disclosed are various approaches for determining a version of an application for a user to access based at least in part an overall posture of the user and the device launching the application. An application can support multiple delivery mechanisms to allow a user different ways to access the service provided by the application. A posture level (e.g., level of risk, level of compliance) associated with the overall posture of a device and user accessing an application is determined. The posture level can be used to select which version of the application should be launched by the device in order to provide the best experience for the user while ensuring that security is considered.

Abstract: A composition for electroless plating comprises: from 9 to 29 weight percent, 9.7 to 29 weight percent, or 10 to 29 weight percent, of a first graft rubber copolymer which comprises the polymerized form of at least one conjugated diene monomer and at least one monovinyl aromatic monomer, from 70 to 90 weight percent, preferably 70-89.7 weight percent, more preferably 70 to 85 weight percent, of ungrafted styrenic polymer, from 0.1 to 10 weight percent of a core/shell diene-based rubber having particle size of 100 to 500 nanometers (nm), one or more of a stabilizer and/or antioxidant in total amount of from 0.1 to 5 weight percent, a fatty acid or a salt of fatty acid in an amount of from 0.1 to 2 weight percent, 0 to 5 weight percent of a mold release agent, 0 to 1 weight percent of a metal oxide, 0 to 3 weight percent of a lubricant, and 0 to 20 weight percent of polycarbonate wherein weight percent and ppm are based on total weight of the composition.

Abstract: Disclosed are various embodiments for virtual desktop infrastructure optimization. A computing device can create a plurality of predictions for future demand for the VDI, each of the plurality of predictions using a respective one of a plurality of resource models, each representing a separate approach to predict future demand for the VDI. Then, the computing device can calculate a plurality of anticipated resource costs, each of the plurality of anticipated resource costs being based at least in part on a respective one of the plurality of predictions for future demand for the VDI. Moreover, the computing device can include, within a user interface, the plurality of predictions for future demand and the plurality of anticipated resource costs. Then, the computing device can implement a resource model from the plurality of resource models to manage an allocation of resources for the VDI in response to a selection of the resource model through the user interface.

Abstract: Estimating conductive hearing loss from wideband acoustic immittance can be accomplished by use of an analog-electric model of an ear canal and inner ear utilized to convert acoustic measurements into output data. The output data can be used to create conductive hearing loss methods for diagnostically estimating hearing loss based upon the acoustic measurements. The model includes a number of inputs from the acoustic measurements that are fit and converted to the output data that can be compared to measured data for hearing loss to train a system to quickly and easily diagnose an estimated hearing loss, such as via a diagnostic tool. The system can also be trained to identify an ear type based upon the transformed acoustic measurement data, and the type of ear can be used to provide additional hearing loss estimation.

Abstract: Estimating inner and middle ear pathologies and conditions, such as issues caused by effusion in the ear, from wideband acoustic immittance can be accomplished by use of an analog-electric model of an ear canal and inner ear. The model is utilized to convert acoustic measurements into output data. The output data can be used to train a machine learning network to identify classifiers that would indicate the presence of an issue in the ear, such as the presence and amount of effusion in the ear. The model is based upon ear mechanics and includes a number of inputs from the acoustic measurements that are fit and converted to the output data that can be compared to measured data for hearing loss to train a system to quickly and easily diagnose an estimated effusion volume or other condition, such as via a diagnostic tool.

Abstract: A system for automated focus tracking of a sample is disclosed. The system comprises an illumination source, a set of illumination optics in an illumination path, a set of collection optics in a collection path, a first slit device in the illumination path, a second slit device in the collection path, at least one detector configured to generate an image of the sample, and a controller configured to receive through-focus information from the image, and provide corrective motion to a stage holding the sample to maintain a position of the sample at a selected focus. A method for automated focus tracking of a sample is also disclosed.

Abstract: A method of and system for dynamically preparing an image-based repair plan for a damaged motor vehicle and for preparing an interactive repair that includes an image of the vehicle, as well as metadata that have been tagged onto the image, for use by repair technicians.

Abstract: A non-transitory processor-readable medium storing code representing instructions to cause a processor to perform a process includes code to cause the processor to receive a set of indications of allowed behavior associated with an application. The processor is also caused to initiate an instance of the application within a sandbox environment. The processor is further caused to receive, from a monitor module associated with the sandbox environment, a set of indications of actual behavior of the instance of the application in response to initiating the instance of the application within the sandbox environment. The processor is also caused to send an indication associated with an anomalous behavior if at least one indication from the set of indications of actual behavior does not correspond to an indication from the set of indications of allowed behavior.

Abstract: A non-transitory processor-readable medium storing code representing instructions to cause a processor to perform a process includes code to cause the processor to receive a set of indications of allowed behavior associated with an application. The processor is also caused to initiate an instance of the application within a sandbox environment. The processor is further caused to receive, from a monitor module associated with the sandbox environment, a set of indications of actual behavior of the instance of the application in response to initiating the instance of the application within the sandbox environment. The processor is also caused to send an indication associated with an anomalous behavior if at least one indication from the set of indications of actual behavior does not correspond to an indication from the set of indications of allowed behavior.

Abstract: A hardware turnstile including a system-on-chip data security appliance (a diode). The diode includes a single-chip device defining a protected boundary co-incident with a boundary of the single-chip device, a first and a second communication interface, an electronic processor located within the protected boundary, a data transfer control component located within the protected boundary, and memory located within the protected boundary. The electronic processor is configured to selectively allow a designated one-way transfer of data appearing on the first communication interface to the second communication interface using the data transfer control component, based on data stored in the memory.

Abstract: A portable workstation for use in a front passenger seat in an interior of a vehicle includes a body member having a plurality of walls that, together, form a box-shape configuration defining a closed bottom, an open top, and an interior area. The body member includes side walls having lower edges that are angled and increasingly offset from the bottom wall so as to be complementary to a bottom of the front passenger seat. A front wall extends downwardly from the bottom wall and in front of the front passenger seat, whereby to grip the front passenger seat. Walls extend upwardly to form compartments for receiving an article. The portable workstation includes a module attachment assembly having a plurality of upstanding side walls and a top surface defining multiple receiver slots. The workstation includes multiple accessory modules each having at least one boss removably received in a receiver slot.