Patents by Inventor Stephen Thom

Stephen Thom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 8-OXOADENINE DERIVATIVES ACTING AS MODULATORS OF TLR7
    Publication number: 20100240623
    Abstract: The present invention provides 8-oxoadenine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The 8-oxoadenine derivatives act as modulators of Toll-like Receptor (TLR) 7 and thus may be used in the treatment of asthma, hepatitis, allergic diseases, viral and bacterial infection as well as cancer.
    Type: Application
    Filed: July 3, 2007
    Publication date: September 23, 2010
    Inventors: Anthony Cook, Tom McInally, Stephen Thom, Hiroki Wada
  • 9-SUBSTITUTED-8-OXO-ADENINE COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR7 ) MODULATORS
    Publication number: 20100130491
    Abstract: The present invention provides compounds of formula (I) wherein R1, Y1, X1, L and R2 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: March 19, 2008
    Publication date: May 27, 2010
    Inventors: Roger Victor Bonnert, Thomas Mcinally, Stephen Thom
  • Substituted indole derivatives for pharmaceutical compositions for treating respiratory diseases
    Patent number: 7709521
    Abstract: The present invention relates to substituted indoles of formula (I) useful as pharmaceutical compounds for treating respiratory disorders.
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: May 4, 2010
    Assignee: AstraZeneca AB
    Inventors: Roger Victor Bonnert, Anthony Ronald Cook, Timothy Jon Luker, Rukhsana Tasneem Mohammed, Stephen Thom
  • 9-SUBSTITUTED-8-OXO-ADENINE COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR7) MODULATORS
    Publication number: 20100087443
    Abstract: The present invention provides compounds of formula where n, R1, R2, A, X1, Y1, Z1, X2 and Y2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: March 19, 2008
    Publication date: April 8, 2010
    Inventors: Roger Victor Bonnert, Thomas McInally, Stephen Thom
  • Cathepsin cysteine protease inhibitors and their use
    Patent number: 7605159
    Abstract: The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin S. In addition this invention also discloses processes for the preparation of such inhibitors.
    Type: Grant
    Filed: December 11, 2003
    Date of Patent: October 20, 2009
    Assignee: AstraZeneca AB
    Inventors: Judith McInally, Garry Pairaudeau, Anil Patel, Stephen Thom
  • Novel Compounds
    Publication number: 20090209524
    Abstract: The present invention provides compounds of formula (1) wherein R1, R2, R3 and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: November 20, 2008
    Publication date: August 20, 2009
    Applicant: AstraZeneca AB
    Inventors: Nicholas J. BENNETT, Thomas MCINALLY, Tobias MOCHEL, Stephen THOM, Anna-Karin TIDEN
  • Novel Compounds
    Publication number: 20090192163
    Abstract: The invention relates to substituted phenylacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Application
    Filed: October 5, 2006
    Publication date: July 30, 2009
    Applicant: ASTRAZENECA AB
    Inventors: Timothy Jon Luker, Rukhsana Tanseem Mohammed, Stephen Thom, Anil Patel
  • Phenoxyacetic Acid Derivatives Useful for Treating Respiratory Diseases
    Publication number: 20090149448
    Abstract: The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Application
    Filed: November 22, 2005
    Publication date: June 11, 2009
    Applicant: ASTRAZENECA AB
    Inventors: Lilian Alcaraz, Roger Victor Bonnert, Anthony Ronald Cook, Timothy Jon Luker, Rukhsana Tasneem Mohammed, Stephen Thom
  • PURINE DERIVATIVES HAVING IMMUNO-MODULATING PROPERTIES
    Publication number: 20090143400
    Abstract: The present invention provides compounds of formula wherein n, Y, Z, R, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: September 12, 2006
    Publication date: June 4, 2009
    Inventors: Thomas McInally, Stephen Thom, Hiroki Wada
  • PURINE DERIVATIVES FOR THE TREATMENT OF VIRAL OR ALLERGIC DISEASES AND CANCERS
    Publication number: 20090082332
    Abstract: The present invention provides compounds of formula (I) wherein R1, Y1, X1, Z1, X2, Y2, A, Y3, n, R and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: September 20, 2006
    Publication date: March 26, 2009
    Inventors: Philip Abbot, Roger Victor Bonnert, Stephen Brough, Kamaldeep Chohan, Thomas McInally, Stephen Thom, Yoshiaki Isobe, Kei Nakamura, Shingo Tojo
  • Biphenyloxyacetic Acid Derivatives for the Treatment of Respiratory Disease
    Publication number: 20090036535
    Abstract: The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Application
    Filed: October 5, 2006
    Publication date: February 5, 2009
    Applicant: ASTRAZENECA AB
    Inventors: Timothy Jon Luker, Rukhsana Tanseem Mohammed, Mark Dickinson, Stephen Thom
  • NOVEL COMPOUNDS
    Publication number: 20080300244
    Abstract: The present invention provides compounds of formula wherein R1, Y1, X1, Z1, X2, Y2, A, n and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: December 13, 2007
    Publication date: December 4, 2008
    Applicant: AstraZeneca AB
    Inventors: Roger Victor BONNERT, Thomas McInally, Tobias Mochel, Stephen Thom
  • Substituted Diphenylethers, -Amines, -Sulfides and -Methanes for the Treatment of Respiratory Disease
    Publication number: 20080293775
    Abstract: The invention relates to substituted diphenylethers, -amines, -sulfides, and -methanes as useful pharmaceutical compounds for treating respiratory-disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Application
    Filed: December 12, 2006
    Publication date: November 27, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Roger Victor Bonnert, Andrew Cook, Timothy Jon Luker, Rukhsana Tasneem Mohammed, Stephen Thom
  • Purine-or pyrrolol[2,3-d]pyrimidine-2-carbonitiles for treating diseases associated with cysteine protease activity
    Patent number: 7439240
    Abstract: The present invention therefore provides a compound of formula (I) and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin S. In addition this invention also discloses processes for the preparation of such inhibitors.
    Type: Grant
    Filed: June 23, 2003
    Date of Patent: October 21, 2008
    Assignee: AstraZeneca AB
    Inventors: Andrew Bailey, Garry Pairaudeau, Anil Patel, Stephen Thom
  • Novel Compounds
    Publication number: 20080234274
    Abstract: The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin S. In addition this invention also discloses processes for the preparation of such inhibitors.
    Type: Application
    Filed: June 3, 2008
    Publication date: September 25, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Andrew Bailey, Garry Pairaudeau, Anil Patel, Stephen Thom
  • Novel Compounds
    Publication number: 20080125426
    Abstract: The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin S. In addition this invention also discloses processes for the preparation of such inhibitors.
    Type: Application
    Filed: February 1, 2008
    Publication date: May 29, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Andrew Bailey, Garry Pairaudeau, Anil Patel, Stephen Thom
  • Novel Compounds
    Publication number: 20080119469
    Abstract: The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin S. In addition this invention also discloses processes for the preparation of such inhibitors.
    Type: Application
    Filed: February 1, 2008
    Publication date: May 22, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Andrew Bailey, Garry Pairaudeau, Anil Patel, Stephen Thom
  • Substituted Acids for the Treatment of Respiratory Diseases
    Publication number: 20080114002
    Abstract: The invention relates to substituted acids of formula (I), where T, W, X, Y, Z, R1 and R2 as defined in the claims, as useful pharmaceutical compounds for treating asthma and rhinitis, pharmaceutical compositions containing them, and a processes for their preparation.
    Type: Application
    Filed: July 6, 2005
    Publication date: May 15, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Roger Bonnert, Stephen Thom, Anil Patel, Timothy Luker
  • Modulators of Crth-2 Receptor Activity for the Treatment of Prostaglandin D2 Mediated Diseases
    Publication number: 20070249686
    Abstract: The invention relates to substituted acids as useful pharmaceutical compounds for treating respiratory disorders as asthma, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Application
    Filed: October 3, 2005
    Publication date: October 25, 2007
    Applicant: ASTRAZENECA AB
    Inventors: Roger Bonnert, Timothy Luker, Garry Pairaudeau, Stephen Thom
  • Wallpaper steamer
    Patent number: D601767
    Type: Grant
    Filed: June 24, 2008
    Date of Patent: October 6, 2009
    Assignee: Earlex Limited
    Inventors: Michael Duncan, Richard Stephen Thom