Abstract: Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, among other things, in the treating of DMD and modulating inflammatory inhibitors IL-1, IL-6 or TNF-?.

Abstract: Method(s), apparatus, and system(s) are provided for filtering a set of data, the set of data comprising multiple data instances by: receiving a set of scores for the set of data; determining attention filtering information based on prior knowledge of one or more relationships between the data instances in said set of data and calculating attention relevancy weights corresponding to the data instances and the set of scores; and providing the attention filtering information to a machine learning, ML, technique or ML model.

Abstract: The invention relates to cheese and cheese-like products comprising about 0.2 to about 6% by weight ?s-casein, ?-casein, or a combination thereof, at least about 5% by weight of one or more hydrocolloids comprising one or more starches, and wherein the cheese or cheese-like product has one or more characteristics of a dairy product, such as flavour, taste, aroma, body, appearance, texture, firmness, handling, density, structure, coagulation, binding, leavening, aeration, foaming, emulsification, elasticity, viscoelasticity, melt, creaminess and mouthfeel.

Abstract: Provided dihydroquinazolinone and azadihydroquinazolinone compounds for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction.

Abstract: Examples of stackable exercise cushions are disclosed. The cushions include a body and are defined by shaped top and bottom surfaces. The shaped top surface has a side-view profile with at least one concave portion and at least one raised portion adjacent to the at least one concave portion such that, from a top view of the body, the at least one raised portion is at a perimeter of the at least one concave portion. The shaped bottom surface has a side-view profile with at least one concave portion underneath the at least one raised portion of the shaped top surface, at least one convex portion underneath the at least one concave portion of the shaped top surface, and at least one flat portion such that, from a bottom view of the body, the at least one flat portion is at a perimeter of the shaped bottom surface.

Abstract: This disclosure describes a system that allows a user to communicate via social networking from a game controller. These social networking notifications may be displayed on a screen of the game controller. In addition to the game controller, the disclosed system may comprise an app, on a device external from the game controller, that is also able to display the social networking notifications.

Abstract: The present disclosure generally relates to substituted quinolinone amide compounds or salts of Formula (I), (II-A), (IV), or (III) and pharmaceutical compositions thereof. The substituted quinolinone amide compounds or salts of Formula (I), (II-A), (IV), or (III) disclosed herein may be used to treat or prevent cardiac disease in an individual in need thereof.

Abstract: Provided are quinazolinone dione compounds for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction.

Abstract: A customer's affinity towards a plurality of mattresses displayed in a brick and mortar store is determined. The probability of the customer purchasing at least one of the displayed mattresses is extrapolated based on the customer's affinity towards each of the mattresses. Customer engagement with each of the mattresses is determined based on the pressure data obtained from embedded pressure sensors responsive to the body pressure. The pressure data and the information indicative of a total number of positions taken up by the customer on each of the mattresses, time spent by the customer on each of the mattresses in each of the positions, and the total time spent by the customer on each of the mattresses are fed to a neural network as inputs, with the neural network determining an affinity score indicative of the customer's affinity towards each of the mattresses.

Abstract: A fitness apparatus is disclosed herein. The fitness apparatus includes a treadmill, the treadmill having one or more displaceable treadmill elements that are configured to receive a user thereon; and at least one resistance assembly coupled to the treadmill, the at least one resistance assembly configured to create a resistance load for the user so that the user is able to perform strength exercises while simultaneously performing cardiovascular exercises on the treadmill.

Abstract: The invention relates to cheese and cheese-like products comprising about 0.2 to about 6% by weight ?s-casein, ?-casein, or a combination thereof, at least about 5% by weight of one or more hydrocolloids comprising one or more starches, and wherein the cheese or cheese-like product has one or more characteristics of a dairy product, such as flavour, taste, aroma, body, appearance, texture, firmness, handling, density, structure, coagulation, binding, leavening, aeration, foaming, emulsification, elasticity, viscoelasticity, melt, creaminess and mouthfeel.

Abstract: This disclosure describes a system that allows a user to communicate via social networking from a game controller. These social networking notifications may be displayed on a screen of the game controller. In addition to the game controller, the disclosed system may comprise an app, on a device external from the game controller, that is also able to display the social networking notifications.

Abstract: Examples of an exercise mat having a three-dimensional surface texture and methods for making same are disclosed. The exercise mat may have a first malleable layer formed from a polyurethane material with an elastic fabric material attached to a lower surface thereof. A second layer may be attached to the elastic fabric material of the first layer. The second layer may be formed from a thermoplastic elastomer material and may have the three-dimensional surface texture formed on an upper surface thereof to which the first layer conforms. The exercise mat may also include a third rubber layer attached to the second layer.

Abstract: The technology described herein is directed to IL-4 and/or IL-13 inhibitors and uses thereof.

Abstract: A system for combusting fuel comprising an apparatus that receives fuel that is characterized as comprising interstitial spacing and wherein oxidants pass through the interstitial spacing of the fuel to sustain a combustion reaction at the interface of a reaction chamber while the byproducts of combustion pass into the reaction chamber.

Abstract: Systems, apparatus, articles of manufacture, and methods are disclosed to perform dynamic function control. An example apparatus includes interface circuitry, machine-readable instructions, and at least one processor circuit to be programmed by the machine-readable instructions to parse a packet for a function directive, activate a function associated with the function directive based on a type of the function directive being associated with an activation instruction, disable the function associated with the function directive based on the type of the function directive being associated with a deactivation instruction, and publish an active function list (AFL) and a passive function list (PFL) based on the type of the function directive.

Abstract: Systems and methods are provided for adaptive flow across multiple water heaters. The system may include a plurality of water heaters provided in a cascaded arrangement, with each of the water heaters including a valve. The valves may be, for example, motorized isolation valves that may be automatically closed and/or opened by one or more controllers associated with the water heaters. This may allow for the system to automatically regulate the flow rate through each of the water heaters to provide for optimal usage of the cascaded water heaters. For example, if it is determined by the one or more controllers (based on sensor data from the water heaters) that a flow rate has decreased below a threshold value for a giving water heater firing rate, one or more valves may be closed such that fewer water heaters are used and the flow rate is increased.

Abstract: A multilayer electrical component including a plurality of parallel plate electrodes embedded in a dielectric body between first and second conductive terminations is disclosed. The plurality of parallel plate electrodes form a stack of electrode layers, which are embedded in the dielectric body, where one or more gaps in each of the respective parallel plate electrodes forms electrically isolated plate portions. The interaction between the electrically isolated plate portions of the parallel plate electrodes in adjacent electrode layers produces a piezoelectric effect, having a corresponding force. The gaps in the parallel plate electrodes are offset relative to a gap in a separate nearby associated parallel plate electrodes, thereby resulting in the associated corresponding forces being directed away from a common boundary.

Abstract: Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, among other things, in the treating of DMD and modulating inflammatory inhibitors IL-1, IL-6 or TNF-?.

Abstract: Responsive to a user request, a controller operates an engine of a vehicle while parked to charge a traction battery to a target state of charge that exceeds a maximum state of charge limit, used during drive of the vehicle by an electric machine, in advance of a predefined period of time.