Abstract: A method for a radiation treatment system includes: a treatment-delivering X-ray source configured to rotate about an isocenter of the radiation treatment system and direct treatment X-rays to a target volume; an imaging X-ray source configured to rotate about the isocenter of the radiation treatment system and direct imaging X-rays to a target region that includes the target volume; and a processor.

Abstract: A radiation treatment system includes a rotatable gantry that is configured to rotate about a treatment isocenter of the radiation therapy system, a treatment-delivering radiation source that is coupled to the rotatable gantry and directs a treatment beam through the treatment isocenter of the radiation therapy system, a first X-ray imager that is coupled to the rotatable gantry, and a second X-ray imager that is mounted on a component of the radiation therapy system and is fixed in position relative to a couch of the radiation therapy system while the rotatable gantry rotates about the treatment isocenter.

Abstract: These various embodiments can serve to facilitate optimizing a radiation treatment plan to administer therapeutic radiation to a particular patient using a particular radiation treatment platform (that may include, for example, a medical linear accelerator) located at a facility having a radiation treatment platform user interface.

Abstract: A method for a radiation therapy system comprises: causing a graphical representation of a movable support couch of the X-ray imaging system to be displayed, wherein the graphical representation includes one or more reference markers that each correspond to a respective physical feature of the movable support couch; receiving a first user input that includes a first position indicator that corresponds to a first boundary of an X-ray imaging region; and generating an X-ray image of the X-ray imaging region, wherein a first edge of the X-ray image corresponds to the first boundary.

Abstract: The present invention relates to methods and kits for radiolabelling a chelate-functionalized targeting agent with a metal radionuclide being gallium-68, using a stabiliser that prevents radiolysis (product degradation) of the chelate-functionalized targeting agent, wherein said stabiliser is selected from the group consisting of: ascorbic acid, dehydroascorbic acid, gentisic acid, cysteine and methionine, sodium ascorbate, or a salt thereof, preferably as a solution. The invention further relates to the use of said stabilizer against radiolytic decomposition of a radiolabelled chelate-functionalized targeting agent composition and methods of detecting a prostate tumour or cancer using the method for radiolabelling.

Abstract: Systems and methods for the automatic generation and optimization of radiation therapy treatment plans, and systems and methods for the automatic generation and optimization of an adapted plan in an adaptive radiation therapy workflow.

Abstract: The disclosure features methods and systems that include directing an ion beam to a region of a sample to liberate charged particles from the region of the sample, where the directed ion beam is pulsed at a first repetition rate, deflecting a first subset of the liberated charged particles from a first path to a second path different from the first path in response to a gate signal synchronized with the repetition rate of the pulsed ion beam, and detecting the first subset of the liberated charged particles in a time-of-flight (TOF) mass spectrometer to determine information about the sample, where the gate signal sets a common reference time for the TOF mass spectrometer for the first subset of charged particles liberated by each pulse of the ion beam.

Abstract: A computer-implemented method of performing radiation therapy on a target volume within an anatomical region of a patient includes: acquiring a cone-beam computed tomography (CBCT) image of the region while the region is positioned in a first preliminary treatment location; reconstructing a current digital volume of the region based on the CBCT image of the region; generating a first beam's-eye-view of the region based on the current digital volume and an offset between the first preliminary treatment location and a reference treatment location; modifying the first beam's-eye-view of the region with one or more visual cues associated with a treatment field for the target volume; and displaying the first beam's-eye-view with the one or more visual cues.

Abstract: In one embodiment, the present disclosure is directed to a system for digital authentication. A device includes a second processor for security functionality. The second processor generates a public key and a private key, and uses the private key and to-be-signed signature data to generate digital signatures. The device transmits the public key and a first digital signature to the server. As part of subsequent communication, the device transmits the public key and a second digital signature to the server. Using the public key, the server validates the second digital signature to verify that the second digital signature is from the device or a user of the device, thereby verifying that the subsequent communication is from the device or the user of the device.

Abstract: An example method for a radiation therapy system that includes a movable couch to perform radiation therapy has been disclosed. One method includes based on the X-ray images of an anatomical region of the patient that includes a target volume, reconstructing a digital volume of the anatomical region and based on a user input indicating a location of a patient origin in the digital volume, determining one or more shift values for repositioning the patient origin at an isocenter of the radiation therapy system with respect to a coordinate system. The method also includes obtaining a treatment plan that is based on the location of the patient origin and is associated with the target volume, based on the treatment plan, repositioning the movable couch so that the patient origin is disposed at the isocenter, and while the patient origin is disposed at the isocenter, directing a treatment beam to the patient origin in accordance with the treatment plan associated with the target volume.

Abstract: In one embodiment, the present disclosure is directed to a system for digital authentication. A device includes a second processor for security functionality. The second processor generates a public key and a private key, and uses the private key and to-be-signed signature data to generate digital signatures. The device transmits the public key and a first digital signature to the server. As part of subsequent communication, the device transmits the public key and a second digital signature to the server. Using the public key, the server validates the second digital signature to verify that the second digital signature is from the device or a user of the device, thereby verifying that the subsequent communication is from the device or the user of the device.

Abstract: An example method for a radiation therapy system that includes a movable couch to perform radiation therapy has been disclosed. One method includes based on the X-ray images of an anatomical region of the patient that includes a target volume, reconstructing a digital volume of the anatomical region and based on a user input indicating a location of a patient origin in the digital volume, determining one or more shift values for repositioning the patient origin at an isocenter of the radiation therapy system with respect to a coordinate system. The method also includes obtaining a treatment plan that is based on the location of the patient origin and is associated with the target volume, based on the treatment plan, repositioning the movable couch so that the patient origin is disposed at the isocenter, and while the patient origin is disposed at the isocenter, directing a treatment beam to the patient origin in accordance with the treatment plan associated with the target volume.

Abstract: Provided herein are halogenated cholesterol analogues, including methods of making and using the same. Also provided are methods of making radiolabeled cholesterol analogues including admixing an epoxide with a fluorine-18 source under conditions to form a radiofluorinated cholesterol analogue.

Abstract: Systems and methods for the automatic generation and optimization of radiation therapy treatment plans, and systems and methods for the automatic generation and optimization of an adapted plan in an adaptive radiation therapy workflow.

Abstract: The disclosure features methods and systems that include directing an ion beam to a region of a sample to liberate charged particles from the region of the sample, where the directed ion beam is pulsed at a first repetition rate, deflecting a first subset of the liberated charged particles from a first path to a second path different from the first path in response to a gate signal synchronized with the repetition rate of the pulsed ion beam, and detecting the first subset of the liberated charged particles in a time-of-flight (TOF) mass spectrometer to determine information about the sample, where the gate signal sets a common reference time for the TOF mass spectrometer for the first subset of charged particles liberated by each pulse of the ion beam.

Abstract: Systems and methods for the automatic generation and optimization of radiation therapy treatment plans, and systems and methods for the automatic generation and optimization of an adapted plan in an adaptive radiation therapy workflow.

Abstract: A computer-implemented method of performing radiation therapy on a target volume within an anatomical region of a patient includes: acquiring a cone-beam computed tomography (CBCT) image of the region while the region is positioned in a first preliminary treatment location; reconstructing a current digital volume of the region based on the CBCT image of the region; generating a first beam's-eye-view of the region based on the current digital volume and an offset between the first preliminary treatment location and a reference treatment location; modifying the first beam's-eye-view of the region with one or more visual cues associated with a treatment field for the target volume; and displaying the first beam's-eye-view with the one or more visual cues.

Abstract: A method for a radiation therapy system comprises: causing a graphical representation of a movable support couch of the X-ray imaging system to be displayed, wherein the graphical representation includes one or more reference markers that each correspond to a respective physical feature of the movable support couch; receiving a first user input that includes a first position indicator that corresponds to a first boundary of an X-ray imaging region; and generating an X-ray image of the X-ray imaging region, wherein a first edge of the X-ray image corresponds to the first boundary.

Abstract: A method for a radiation treatment system includes: a treatment-delivering X-ray source configured to rotate about an isocenter of the radiation treatment system and direct treatment X-rays to a target volume; an imaging X-ray source configured to rotate about the isocenter of the radiation treatment system and direct imaging X-rays to a target region that includes the target volume; and a processor.

Abstract: A method for forming a hybrid heat exchanger is provided. The method includes laser-texturing a metal surface to create a plurality of microstructures and subsequently melt-bonding a plastic component to the plurality of microstructures. During melt-bonding, plastic material penetrates the plurality of microstructures and conforms to the plastic component to the metal surface. After hardening inside the microstructures, the plastic component adheres to the metal surface as a hybrid component. As a result, a fastener or snap connection is not required, and the plastic-metal joint provides a barrier to water, glycol-based fluids, air, and other fluids.