Abstract: Example methods and systems for multiresolution image reconstruction with upscaling are described. In one example, a computer system may obtain first volume image data associated with a first resolution level. The computer system may upscale the first volume image data associated with the first resolution level to generate second volume image data associated with a second resolution level, which is higher than the first resolution level. The computer system may obtain mask image data that identifies a region of interest (ROI) associated with a target structure. Based on the second volume image data and the mask image data, the computer system may generate multiresolution volume image data that includes at least a first voxel associated with the second resolution level outside of the ROI, and a second voxel associated with a third resolution level within the ROI.

Abstract: Example methods and systems for iterative image reconstruction with upscaling are described. In one example, a computer system may obtain projection image data associated with a target structure of a patient. The computer system may perform iterative image reconstruction for a first number of iterations to generate first volume image data based on the projection image data. The first volume image data may be associated with a first resolution level. The computer system may upscale the first volume image data associated with the first resolution level to generate second volume image data associated with a second resolution level that is higher than the first resolution level. The computer system may perform iterative image reconstruction for a second number of iterations to generate output volume image data associated with the second resolution level based on the second volume image data.

Abstract: A method for manufacturing a double-skinned plate (1) incorporating channels (2) constituting at least one fluid circulation network or circuit. The method includes a first step of providing two flat aluminium sheets (3 and 3?), followed by a step of joining them together by laser welding, according to a linear pattern (4) tracing the pattern of the circulation channels (2), the two flat aluminium sheets (3 and 3?) into a double-skinned plate (1). There is another step of forming the circulation channels (2) by injecting a pressurized liquid or gaseous fluid (LP) between the two sheets (3 and 3?). The method also includes a step of flattening the plate (1) having the two sheets (3 and 3?) joined together by laser welding before the step of forming, by pressure deformation, the circulation channels (2).

Abstract: A heat exchanger (10) for a battery housing comprising a first panel (12), a second panel (14), and a plurality of cooling fluid circulation channels (16) therebetween. The first panel has an exterior surface (18) and a channel surface (20) opposite the exterior surface. The second panel has a cooling surface (22) and an abutment surface (24) opposite the cooling surface, and is welded to the first panel via a network of channel seams. The plurality of cooling fluid circulation channels are defined by the channel surface and the abutment surface. Each of the plurality of cooling fluid circulation channels are disposed between a first and a second channel seam (26a,26b) and define a central flow cavity (28) that narrows into a first and a second crevice (30a,30b). Each of the first and the second crevice has a length (L) and a width (W), and L2/W that is less than 250.

Abstract: Example methods and systems for image reconstruction using multiple image reconstruction chains for radiation therapy are described. In one example, a computer system may obtain projection image data associated with a target structure within a patient. The computer system may generate, using a first image reconstruction chain, first volume image data based on the projection image data. The computer system may generate and display, on a display device, a first user interface (UI) view for a user to interact with the first volume image data. The computer system may also generate, using a second image reconstruction chain, second volume image data based on at least one of the following: the projection image data and the first volume image data. The computer system may generate and display, on the display device, a second UI view for the user to interact with the second volume image data.

Abstract: A method for a radiation treatment system includes: a treatment-delivering X-ray source configured to rotate about an isocenter of the radiation treatment system and direct treatment X-rays to a target volume; an imaging X-ray source configured to rotate about the isocenter of the radiation treatment system and direct imaging X-rays to a target region that includes the target volume; and a processor.

Abstract: A radiation treatment system includes a rotatable gantry that is configured to rotate about a treatment isocenter of the radiation therapy system, a treatment-delivering radiation source that is coupled to the rotatable gantry and directs a treatment beam through the treatment isocenter of the radiation therapy system, a first X-ray imager that is coupled to the rotatable gantry, and a second X-ray imager that is mounted on a component of the radiation therapy system and is fixed in position relative to a couch of the radiation therapy system while the rotatable gantry rotates about the treatment isocenter.

Abstract: These various embodiments can serve to facilitate optimizing a radiation treatment plan to administer therapeutic radiation to a particular patient using a particular radiation treatment platform (that may include, for example, a medical linear accelerator) located at a facility having a radiation treatment platform user interface.

Abstract: A method for a radiation therapy system comprises: causing a graphical representation of a movable support couch of the X-ray imaging system to be displayed, wherein the graphical representation includes one or more reference markers that each correspond to a respective physical feature of the movable support couch; receiving a first user input that includes a first position indicator that corresponds to a first boundary of an X-ray imaging region; and generating an X-ray image of the X-ray imaging region, wherein a first edge of the X-ray image corresponds to the first boundary.

Abstract: The present invention relates to methods and kits for radiolabelling a chelate-functionalized targeting agent with a metal radionuclide being gallium-68, using a stabiliser that prevents radiolysis (product degradation) of the chelate-functionalized targeting agent, wherein said stabiliser is selected from the group consisting of: ascorbic acid, dehydroascorbic acid, gentisic acid, cysteine and methionine, sodium ascorbate, or a salt thereof, preferably as a solution. The invention further relates to the use of said stabilizer against radiolytic decomposition of a radiolabelled chelate-functionalized targeting agent composition and methods of detecting a prostate tumour or cancer using the method for radiolabelling.

Abstract: Systems and methods for the automatic generation and optimization of radiation therapy treatment plans, and systems and methods for the automatic generation and optimization of an adapted plan in an adaptive radiation therapy workflow.

Abstract: The disclosure features methods and systems that include directing an ion beam to a region of a sample to liberate charged particles from the region of the sample, where the directed ion beam is pulsed at a first repetition rate, deflecting a first subset of the liberated charged particles from a first path to a second path different from the first path in response to a gate signal synchronized with the repetition rate of the pulsed ion beam, and detecting the first subset of the liberated charged particles in a time-of-flight (TOF) mass spectrometer to determine information about the sample, where the gate signal sets a common reference time for the TOF mass spectrometer for the first subset of charged particles liberated by each pulse of the ion beam.

Abstract: A computer-implemented method of performing radiation therapy on a target volume within an anatomical region of a patient includes: acquiring a cone-beam computed tomography (CBCT) image of the region while the region is positioned in a first preliminary treatment location; reconstructing a current digital volume of the region based on the CBCT image of the region; generating a first beam's-eye-view of the region based on the current digital volume and an offset between the first preliminary treatment location and a reference treatment location; modifying the first beam's-eye-view of the region with one or more visual cues associated with a treatment field for the target volume; and displaying the first beam's-eye-view with the one or more visual cues.

Abstract: In one embodiment, the present disclosure is directed to a system for digital authentication. A device includes a second processor for security functionality. The second processor generates a public key and a private key, and uses the private key and to-be-signed signature data to generate digital signatures. The device transmits the public key and a first digital signature to the server. As part of subsequent communication, the device transmits the public key and a second digital signature to the server. Using the public key, the server validates the second digital signature to verify that the second digital signature is from the device or a user of the device, thereby verifying that the subsequent communication is from the device or the user of the device.

Abstract: An example method for a radiation therapy system that includes a movable couch to perform radiation therapy has been disclosed. One method includes based on the X-ray images of an anatomical region of the patient that includes a target volume, reconstructing a digital volume of the anatomical region and based on a user input indicating a location of a patient origin in the digital volume, determining one or more shift values for repositioning the patient origin at an isocenter of the radiation therapy system with respect to a coordinate system. The method also includes obtaining a treatment plan that is based on the location of the patient origin and is associated with the target volume, based on the treatment plan, repositioning the movable couch so that the patient origin is disposed at the isocenter, and while the patient origin is disposed at the isocenter, directing a treatment beam to the patient origin in accordance with the treatment plan associated with the target volume.

Abstract: In one embodiment, the present disclosure is directed to a system for digital authentication. A device includes a second processor for security functionality. The second processor generates a public key and a private key, and uses the private key and to-be-signed signature data to generate digital signatures. The device transmits the public key and a first digital signature to the server. As part of subsequent communication, the device transmits the public key and a second digital signature to the server. Using the public key, the server validates the second digital signature to verify that the second digital signature is from the device or a user of the device, thereby verifying that the subsequent communication is from the device or the user of the device.

Abstract: An example method for a radiation therapy system that includes a movable couch to perform radiation therapy has been disclosed. One method includes based on the X-ray images of an anatomical region of the patient that includes a target volume, reconstructing a digital volume of the anatomical region and based on a user input indicating a location of a patient origin in the digital volume, determining one or more shift values for repositioning the patient origin at an isocenter of the radiation therapy system with respect to a coordinate system. The method also includes obtaining a treatment plan that is based on the location of the patient origin and is associated with the target volume, based on the treatment plan, repositioning the movable couch so that the patient origin is disposed at the isocenter, and while the patient origin is disposed at the isocenter, directing a treatment beam to the patient origin in accordance with the treatment plan associated with the target volume.

Abstract: Provided herein are halogenated cholesterol analogues, including methods of making and using the same. Also provided are methods of making radiolabeled cholesterol analogues including admixing an epoxide with a fluorine-18 source under conditions to form a radiofluorinated cholesterol analogue.

Abstract: Systems and methods for the automatic generation and optimization of radiation therapy treatment plans, and systems and methods for the automatic generation and optimization of an adapted plan in an adaptive radiation therapy workflow.

Abstract: The disclosure features methods and systems that include directing an ion beam to a region of a sample to liberate charged particles from the region of the sample, where the directed ion beam is pulsed at a first repetition rate, deflecting a first subset of the liberated charged particles from a first path to a second path different from the first path in response to a gate signal synchronized with the repetition rate of the pulsed ion beam, and detecting the first subset of the liberated charged particles in a time-of-flight (TOF) mass spectrometer to determine information about the sample, where the gate signal sets a common reference time for the TOF mass spectrometer for the first subset of charged particles liberated by each pulse of the ion beam.