Patents by Inventor Stephen Thoms

Stephen Thoms has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenoxiacetic acid derivatives
    Patent number: 8394986
    Abstract: The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Grant
    Filed: July 26, 2011
    Date of Patent: March 12, 2013
    Assignee: AstraZeneca AB
    Inventors: Roger Victor Bonnert, Anil Patel, Stephen Thom
  • NOVEL COMPOUNDS
    Publication number: 20130045955
    Abstract: The present invention provides compounds of formula (I) herein R1, R2, R3 and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: August 16, 2012
    Publication date: February 21, 2013
    Inventors: Nicholas J. Bennett, Thomas MCINALLY, Tobias MOCHEL, Stephen Thom, Anna-Karin Tidén
  • Biphenyloxyacetic acid derivatives for the treatment of respiratory disease
    Patent number: 8349897
    Abstract: The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: January 8, 2013
    Assignee: Astrazeneca AB
    Inventors: Timothy Jon Luker, Rukhsana Tanseem Mohammed, Mark Dickinson, Stephen Thom
  • Compounds
    Patent number: 8268990
    Abstract: The present invention provides compounds of formula (I) wherein R1, R2, R3 and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: September 18, 2012
    Assignees: AstraZeneca AB, Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Nicholas J. Bennett, Thomas McInally, Stephen Thom
  • Biphenyloxyacetic Acid Derivatives for the Treatment of Respiratory Disease
    Publication number: 20120178814
    Abstract: The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Application
    Filed: December 21, 2011
    Publication date: July 12, 2012
    Inventors: Timothy Jon Luker, Rukhsana Tanseem Mohammed, Mark Dickinson, Stephen Thom
  • NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND FURTHER DISEASES
    Publication number: 20120122867
    Abstract: The invention concerns compounds of Formula (I): wherein L1, R1, R2, R3, R4 and X are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment of disease, for example cancer.
    Type: Application
    Filed: May 20, 2010
    Publication date: May 17, 2012
    Inventors: Nicholas James Bennet, Stephen Thom, Thomas Mcinally
  • Compounds
    Patent number: 8158820
    Abstract: The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Grant
    Filed: April 6, 2004
    Date of Patent: April 17, 2012
    Assignee: AstraZeneca AB
    Inventors: Roger Bonnert, Stephen Brough, Andrew Davies, Timothy Luker, Thomas McInally, Ian Millichip, Garry Pairaudeau, Anil Patel, Rukhsana Rasul, Stephen Thom
  • Compounds
    Patent number: 8148572
    Abstract: The invention relates to substituted phenylacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Grant
    Filed: October 5, 2006
    Date of Patent: April 3, 2012
    Assignee: AstraZeneca AB
    Inventors: Timothy Jon Luker, Rukhsana Tasneem Mohammed, Stephen Thom, Anil Patel
  • 8-oxoadenine derivatives acting as modulators of TLR7
    Patent number: 8138172
    Abstract: The present invention provides 8-oxoadenine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The 8-oxoadenine derivatives act as modulators of Toll-like Receptor (TLR) 7 and thus may be used in the treatment of asthma, hepatitis, allergic diseases, viral and bacterial infection as well as cancer.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: March 20, 2012
    Assignees: AstraZeneca AB, Dainippon Sumitomo Pharma Co Ltd.
    Inventors: Anthony Cook, Tom McInally, Stephen Thom, Hiroki Wada
  • Compounds
    Patent number: 8067411
    Abstract: The present invention provides compounds of formula wherein R1, Y1, X1, Z1, X2, Y2, A, n and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: November 29, 2011
    Assignees: AstraZeneca AB, Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Roger Victor Bonnert, Thomas McInally, Tobias Mochel, Stephen Thom
  • 9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7 ) modulators
    Patent number: 8067413
    Abstract: The present invention provides compounds of formula (I) wherein R1, Y1, X1, L and R2 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: November 29, 2011
    Assignees: AstraZeneca AB, Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Roger Victor Bonnert, Thomas McInally, Stephen Thom
  • 9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7) modulators
    Patent number: 8063051
    Abstract: The present invention provides compounds of formula where n, R1, R2, A, X1, Y1, Z1, X2 and Y2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: November 22, 2011
    Assignees: AstraZeneca AB, Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Roger Victor Bonnert, Thomas McInally, Stephen Thom
  • PHENOXIACETIC ACID DERIVATIVES
    Publication number: 20110281898
    Abstract: The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Application
    Filed: July 26, 2011
    Publication date: November 17, 2011
    Inventors: Roger Victor Bonnert, Anil Patel, Stephen Thom
  • Substituted acids for the treatment of respiratory diseases
    Patent number: 8022248
    Abstract: The invention relates to substituted acids of formula (I), where T, W, X, Y, Z, R1 and R2 as defined in the claims, as useful pharmaceutical compounds for treating asthma and rhinitis, pharmaceutical compositions containing them, and a processes for their preparation.
    Type: Grant
    Filed: July 6, 2005
    Date of Patent: September 20, 2011
    Assignee: AstraZeneca AB
    Inventors: Roger Victor Bonnert, Stephen Thom, Anil Patel, Timothy Jon Luker
  • Biphenyloxyacetic acid derivatives for the treatment of respiratory disease
    Patent number: 8008350
    Abstract: The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Grant
    Filed: October 5, 2006
    Date of Patent: August 30, 2011
    Assignee: AstraZeneca AB
    Inventors: Timothy Jon Luker, Rukhsana Tasneem Mohammed, Mark Dickinson, Stephen Thom
  • Phenoxiacetic acid derivatives
    Patent number: 8003703
    Abstract: The invention relates to certain 2-substituted phenoxyacetic acid derivatives of formula (I), in which the variables are as defined in the claims, useful in the treatment of diseases or conditions in which modulation of the CRTh2 receptor is beneficial, such as asthma and rhinitis.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: August 23, 2011
    Assignee: AstraZeneca AB
    Inventors: Roger Victor Bonnert, Anil Patel, Stephen Thom
  • Novel Compounds
    Publication number: 20110166117
    Abstract: The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Application
    Filed: December 30, 2010
    Publication date: July 7, 2011
    Inventors: Roger Bonnert, Stephen Brough, Andrew Davies, Timothy Luker, Thomas McInally, Ian Millichip, Garry Pairaudeau, Anil Patel, Rukhsana Rasul, Stephen Thom
  • Uses of Electromagnetic Interference Patterns
    Publication number: 20110157599
    Abstract: Various uses of visible light interference patterns are provided. Suitable interference patterns are those formed by diffraction from patterns of apertures. Typical uses disclosed herein relate to spatial metrology, such as a translational and/or angular position determination system. Further uses include the analysis of properties of the light itself (such as the determination of the wavelength of the electromagnetic radiation). Still further uses include the analysis of one or more properties (e.g. refractive index) of the matter through which the light passes. Part of the interference pattern is captured at a pixellated detector, such as a CCD chip, and the captured pattern compared with a calculated pattern. Very precise measurements of the spacing between maxima is possible, thus allowing very precise measurements of position of the detector in the interference pattern.
    Type: Application
    Filed: August 25, 2009
    Publication date: June 30, 2011
    Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
    Inventors: Jonathan Mark Ralph Weaver, Phillip Stephen Dobson, David Paul Burt, Stephen Thoms, Kevin Edward Docherty, Yuan Zhang
  • Biphenyloxyacetic Acid Derivatives for the Treatment of Respiratory Disease
    Publication number: 20110152374
    Abstract: The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Application
    Filed: December 20, 2010
    Publication date: June 23, 2011
    Inventors: Timothy Jon Luker, Rukhsana Tasneem Mohammed, Mark Dickinson, Stephen Thom
  • SALTS 756
    Publication number: 20100298364
    Abstract: The invention provides salts of 4-(dimethylamino)butyl 2-(4-((2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)phenyl)acetate, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: May 20, 2010
    Publication date: November 25, 2010
    Applicants: AstraZeneca AB, Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Nicholas James BENNETT, Thomas McInally, Austen Pimm, Stephen Thom, Yoshiaki Isobe