Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Abstract: Described herein are compounds of Formula I, and their pharmaceutically acceptable salts, solvates, stereoisomers, or prodrugs, as well as their uses (e.g., as eIF4E inhibitors).

Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Abstract: A fluid conditioning control system for driving one or more coils in a fluid conditioning system with a target load current to generate an alternating magnetic field directed at a fluid, the control system comprising a controller, a switch mode power supply circuit and a push pull AC drive circuit, wherein the controller is arranged to develop a first variable output having a frequency range that sweeps between a minimum frequency and a maximum frequency, and further arranged to develop a second variable output in the form of a duty cycle controlled signal, wherein the switch mode power supply circuit is arranged to develop a variable supply voltage to the AC drive circuit in response to the second variable output and a current sense circuit, and the AC drive circuit is arranged to develop a drive signal for developing a target load current in response to the first variable output and the variable supply voltage, thereby forming a current feedback loop.

Abstract: A fluid conditioning control system for driving one or more coils in a fluid conditioning system with a target load current to generate an alternating magnetic field directed at a fluid, the control system comprising a controller, a switch mode power supply circuit and a push pull AC drive circuit, wherein the controller is arranged to develop a first variable output having a frequency range that sweeps between a minimum frequency and a maximum frequency, and further arranged to develop a second variable output in the form of a duty cycle controlled signal, wherein the switch mode power supply circuit is arranged to develop a variable supply voltage to the AC drive circuit in response to the second variable output and a current sense circuit, and the AC drive circuit is arranged to develop a drive signal for developing a target load current in response to the first variable output and the variable supply voltage, thereby forming a current feedback loop.

Abstract: A method of transporting a liquid product down a vertical conduit having an inlet provided at the top of the conduit and an outlet provided at the bottom of the conduit, which method comprises feeding the liquid product into the inlet of the conduit and contacting the liquid product with means for dissipating potential energy released by the liquid product as it is transported down the conduit so that turbulence in the liquid product at the outlet of the conduit is reduced.

Abstract: The invention relates to glycogen phosphorylase inhibitor compounds, pharmaceutical compositions of these compounds, methods of treatment using the pharmaceutical compositions to treat diabetes, conditions associated with diabetes, and/or tissue ischemia, including myocardial ischemia, and processes for making the compounds.

Abstract: A method of transporting a liquid product down a vertical conduit having an inlet provided at the top of the conduit and an outlet provided at the bottom of the conduit, which method comprises feeding the liquid product into the inlet of the conduit and contacting the liquid product with means for dissipating potential energy released by the liquid product as it is transported down the conduit so that turbulence in the liquid product at the outlet of the conduit is reduced.

Abstract: The present invention relates generally to inhibitors of the kinases and more particularly to novel pyrazolopyrimidine compounds.

Abstract: The present invention relates generally to inhibitors of the kinases and more particularly to novel pyrazolopyrimidine compounds

Abstract: Apparatus for delivering an emulsion explosives composition comprising unpressurized vessel (10) for storing or supplying the explosives composition to pressure chamber (1); sealable chamber inlet (2) for charging chamber (1) with emulsion explosives composition from vessel (10); and chamber outlet (4). Fluid pressure opening (6) applies a discharge pressure to chamber (1) for delivering emulsion explosives composition through outlet (4) to delivery hose (11) for charging blast holes. The apparatus is characterized by pressure chamber (1) having a maximum operating pressure and a volume such that the pressure volume (pV) value of chamber (1) is less than 10 MPaL.

Abstract: A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.

Abstract: Apparatus for delivering an emulsion explosives composition comprising unpressurised vessel (10) for storing or supplying the explosives composition to pressure chamber (1); sealable chamber inlet (2) for charging chamber (1) with emulsion explosives composition from vessel (10); and chamber outlet (4). Fluid pressure opening (6) applies a discharge pressure to chamber (1) for delivering emulsion explosives composition through outlet (4) to delivery hose (11) for charging blast holes. The apparatus is characterisedby pressure chamber (1) having a maximum operating pressure and a volume such that the pressure volume (pV) value of chamber (1) is less than 10 MPaL.

Abstract: A device for locating and inflating a blasthole plug comprising; (i) a shroud adapted to enclose at least part of a deflated plug as the deflated plug is passed along a blasthole, (ii) an ejection means for removing the deflated plug from the shroud into a desired location in a blasthole, and (iii) an inflation means adapted to be removably connected to the plug, such that when the deflated plug is removed from the shroud, fluid material may be passed through the inflation means to inflate the plug.

Abstract: An apparatus and process for the production of any emulsion explosives composition and loading it into a blast hole (7) which utilize a loading conduit (4) having a shear inducing means (5) and a liquid lubrication source (b) adapted to provide a layer of liquid lubricant between the conduit (4) and emulsion explosives composition being pumped through the loading conduit (4). The conduit also comprises a mixing means (8) located at or near the outlet of the conduit (4), the mixing means (8) incorporates at least some of the liquid layer into the emulsion explosives composition.

Abstract: A device and process for plugging an explosives blasthole, the device having an inner member (7a, 7b) in the form of a conduit having a valve (9) and being adapted for the passage of fluid bulk explosives and an outer member (1) adapted to engage the walls of the blasthole. The outer member may be made of deformable material or be inflatable. The inner and outer members may be detachable.