Patents by Inventor Stephen Tottey

Stephen Tottey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11618771
    Abstract: A fusion protein comprising a target protein, a first recombinant viral coat protein, a second recombinant viral coat protein and a first linkage peptide is provided. The target protein is at N-terminus of the first recombinant viral coat protein. The first recombinant viral coat protein is linked to N-terminus of the first linkage peptide. The second recombinant viral coat protein is linked to C-terminus of the first linkage peptide. The first and second recombinant viral coat proteins are derived from the coat protein (CP) of alfalfa mosaic virus (AIMV). The fusion protein may further comprise a second linkage peptide between the target protein and the first recombinant viral coat protein. The fusion protein may form a virus like particle (VLP). The target protein may be displayed on the surface of the VLP. Also provided are methods for producing the fusion protein and the VLP as well as the uses of the fusion protein and/or the VLP.
    Type: Grant
    Filed: June 29, 2021
    Date of Patent: April 4, 2023
    Assignee: Fraunhofer USA Inc.
    Inventors: Stephen Tottey, Konstantin Musiychuk
  • Publication number: 20210324015
    Abstract: A fusion protein comprising a target protein, a first recombinant viral coat protein, a second recombinant viral coat protein and a first linkage peptide is provided. The target protein is at N-terminus of the first recombinant viral coat protein. The first recombinant viral coat protein is linked to N-terminus of the first linkage peptide. The second recombinant viral coat protein is linked to C-terminus of the first linkage peptide. The first and second recombinant viral coat proteins are derived from the coat protein (CP) of alfalfa mosaic virus (AIMV). The fusion protein may further comprise a second linkage peptide between the target protein and the first recombinant viral coat protein. The fusion protein may form a virus like particle (VLP). The target protein may be displayed on the surface of the VLP. Also provided are methods for producing the fusion protein and the VLP as well as the uses of the fusion protein and/or the VLP.
    Type: Application
    Filed: June 29, 2021
    Publication date: October 21, 2021
    Applicant: Fraunhofer USA Inc.
    Inventors: Stephen Tottey, Konstantin Musiychuk
  • Patent number: 11078240
    Abstract: A fusion protein comprising a first recombinant viral coat protein, a second recombinant viral coat protein and a first linkage peptide is provided. The first recombinant viral coat protein is linked to N-terminus of the first linkage peptide. The second recombinant viral coat protein is linked to C-terminus of the first linkage peptide. The first and second recombinant viral coat proteins are derived from the coat protein (CP) of alfalfa mosaic virus (AIMV). The fusion protein may form a virus like particle (VLP). Where the fusion protein further comprises a target protein, the target protein may be displayed on the surface of the VLP. Also provided are methods for producing the fusion protein and the VLP as well as the uses of the fusion protein and/or the VLP.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: August 3, 2021
    Assignee: Fraunhofer USA Inc.
    Inventors: Stephen Tottey, Konstantin Musiychuk
  • Publication number: 20200181203
    Abstract: A fusion protein comprising a first recombinant viral coat protein, a second recombinant viral coat protein and a first linkage peptide is provided. The first recombinant viral coat protein is linked to N-terminus of the first linkage peptide. The second recombinant viral coat protein is linked to C-terminus of the first linkage peptide. The first and second recombinant viral coat proteins are derived from the coat protein (CP) of alfalfa mosaic virus (AIMV). The fusion protein may form a virus like particle (VLP). Where the fusion protein further comprises a target protein, the target protein may be displayed on the surface of the VLP. Also provided are methods for producing the fusion protein and the VLP as well as the uses of the fusion protein and/or the VLP.
    Type: Application
    Filed: November 10, 2017
    Publication date: June 11, 2020
    Applicant: Fraunhofer USA Inc.
    Inventors: Stephen Tottey, Konstantin Musiychuk
  • Patent number: 9340602
    Abstract: Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in or on a patient also are provided along with methods of growing and repairing bone.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: May 17, 2016
    Assignee: University of Pittsburgh-Of the Commonwealth System of Higher Education
    Inventors: Vineet Agrawal, Stephen F. Badylak, Scott A. Johnson, Stephen Tottey
  • Publication number: 20140294918
    Abstract: Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in or on a patient also are provided along with methods of growing and repairing bone.
    Type: Application
    Filed: April 9, 2014
    Publication date: October 2, 2014
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Vineet Agrawal, Stephen F. Badylak, Scott A. Johnson, Stephen Tottey
  • Patent number: 8716438
    Abstract: Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in or on a patient also are provided along with methods of growing and repairing bone.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: May 6, 2014
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Vineet Agrawal, Stephen F. Badylak, Scott Alan Johnson, Stephen Tottey
  • Publication number: 20130058991
    Abstract: Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in or on a patient also are provided along with methods of growing and repairing bone.
    Type: Application
    Filed: October 8, 2010
    Publication date: March 7, 2013
    Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Vineet Agrawal, Stephen F. Badylak, Scott Alan Johnson, Stephen Tottey