Abstract: In one embodiment, a method of assigning transcripts to probe sets is described that comprises retrieving one or more data sets from one or more sources; generating one or more clusters using transcript data from the data sets; aligning one or more probe sequences to a representative sequence from one or more of the clusters; aligning the representative sequence to a genome sequence, wherein the genome sequence is annotated with probe location information; mapping the aligned probe sequences to the genome sequence using the alignment of the representative sequence and genome sequence; and computing a score using a number associated with the aligned probe sequences and a number associated with the probe location formation associated with a region of the genome sequence that corresponds to the aligned representative sequence.