Abstract: A user of a personal computing device may identify multiple travel items of interest displayed for purchase by a network-based travel service. However, the user may not desire to purchase the travel items in a single purchase. Upon making a travel purchase that includes a first travel item that does not include a second travel item corresponding to the first travel item, the user may employ the network travel package service to search for second travel items corresponding to the first travel item, select from discounted travel packages including the first travel item and second travel items returned from the search, and purchase a discounted travel package. Beneficially, multiple travel items may be purchased separately while obtaining a package discount as compared to the stand-alone price of the travel items.

Abstract: A user of a personal computing device may identify multiple travel items of interest displayed for purchase by a network-based travel service. However, the user may not desire to purchase the travel items in a single purchase. Upon making a travel purchase that includes a first travel item that does not include a second travel item corresponding to the first travel item, the user may employ the network travel package service to search for second travel items corresponding to the first travel item, select from discounted travel packages including the first travel item and second travel items returned from the search, and purchase a discounted travel package. Beneficially, multiple travel items may be purchased separately while obtaining a package discount as compared to the stand-alone price of the travel items.

Abstract: The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a biodegradable microcarrier or nanocarrier.

Abstract: A user of a personal computing device may identify multiple travel items of interest displayed for purchase by a network-based travel service. However, the user may not desire to purchase the travel items in a single purchase. Upon making a travel purchase that includes a first travel item that does not include a second travel item corresponding to the first travel item, the user may employ the network travel package service to search for second travel items corresponding to the first travel item, select from discounted travel packages including the first travel item and second travel items returned from the search, and purchase a discounted travel package. Beneficially, multiple travel items may be purchased separately while obtaining a package discount as compared to the stand-alone price of the travel items.

Abstract: A user of a personal computing device may identify multiple travel items of interest displayed for purchase by a network-based travel service. However, the user may not desire to purchase the travel items in a single purchase. Upon making a travel purchase that includes a first travel item that does not include a second travel item corresponding to the first travel item, the user may employ the network travel package service to search for second travel items corresponding to the first travel item, select from discounted travel packages including the first travel item and second travel items returned from the search, and purchase a discounted travel package. Beneficially, multiple travel items may be purchased separately while obtaining a package discount as compared to the stand-alone price of the travel items.

Abstract: A user of a personal computing device may identify multiple travel items of interest displayed for purchase by a network-based travel service. However, the user may not desire to purchase the travel items in a single purchase. Upon making a travel purchase that includes a first travel item that does not include a second travel item corresponding to the first travel item, the user may employ the network travel package service to search for second travel items corresponding to the first travel item, select from discounted travel packages including the first travel item and second travel items returned from the search, and purchase a discounted travel package. Beneficially, multiple travel items may be purchased separately while obtaining a package discount as compared to the stand-alone price of the travel items.

Abstract: The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a biodegradable microcarrier or nanocarrier.

Abstract: The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a biodegradable microcarrier or nanocarrier.

Abstract: The invention relates to new immunomodulatory compositions which comprise a cationic condensing agent, an immunomodulatory compound, and a stabilizing agent. The compositions of the invention typically form particles which have increased immunomodulatory activity as compared to immunomodulatory compounds not formulated in the compositions of the invention. Also provided are methods of making the compositions and methods for therapeutic use of the compositions.

Abstract: The invention provides methods of modulating an immune response to a second antigen which entail administration of a first antigen and an immunostimulatory polynucleotide. Modulation of the immune response is generally manifested as stimulation of a Th1 response.

Abstract: The invention provides methods of modulating an immune response to a second antigen which entail administration of a first antigen and an immunostimulatory polynucleotide. Modulation of the immune response is generally manifested as stimulation of a Th1 response.

Abstract: The invention relates to new immunomodulatory compositions which comprise a cationic condensing agent, an immunomodulatory compound, and a stabilizing agent. The compositions of the invention typically form particles which have increased immunomodulatory activity as compared to immunomodulatory compounds not formulated in the compositions of the invention. Also provided are methods of making the compositions and methods for therapeutic use of the compositions.

Abstract: The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a nonbiodegradable microcarrier or nanocarrier.

Abstract: The invention provides classes of immunomodulatory compositions which comprise an average of one or more immunostimulatory sequence (ISS) containing polynucleotide conjugated, or attached, to antigen. The extent of conjugation affects immunomodulatory properties, such as extent of antigen-specific antibody form ration, including Th1-associated antibody formation, and thus these various conjugate classes are useful for modulating the type and extent of immune response. The invention also includes methods of modulating an immune response using these compositions.

Abstract: The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a biodegradable microcarrier or noncarrier.

Abstract: The invention provides classes of immunomodulatory compositions which comprise an average of one or more immunostimulatory sequence (ISS) containing polynucleotide conjugated, or attached, to antigen. The extent of conjugation affects immunomodulatory properties, such as extent of antigen-specific antibody formation, including Th1-associated antibody formation, and thus these various conjugate classes are useful for modulating the type and extent of immune response. The invention also includes methods of modulating an immune response using these compositions.

Abstract: The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.

Abstract: The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a nonbiodegradable microcarrier or nanocarrier.

Abstract: The present invention provides compositions comprising conjugate molecules that are structurally stable at a temperature of between about 2 degrees C. and 8 degrees C. In some examples, a conjugate molecule comprises an antigen, such as an allergen. In some examples, a conjugate molecule comprises the Ragweed antigen Amb a 1. The present invention provides methods for making and using such compositions. Provided herein are methods for modulating an immune response in an individual comprising administration of a composition comprising a structurally stable conjugate molecule as described herein.

Abstract: The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a nonbiodegradable microcarrier or nanocarrier.