Patents by Inventor Stephen Turner

Stephen Turner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for nucleic acid sample preparation
    Patent number: 9879318
    Abstract: The present invention provides methods and compositions useful for supplying high throughput nucleic acid sequencing systems with templates. The methods circumvent the need for costly, labor-intensive cloning and cell culture methods and can be scaled to accommodate template production for a variety of sequencing applications, e.g., sequencing individuals' genomes, sequencing subpopulations of transcripts from a gene of interest, and/or gene expression profiling. Particularly preferred embodiments of the methods vastly improve the preparation of cDNA from mRNA samples, e.g., by randomizing errors introduced during the process, thereby allowing these errors to be readily distinguished from true variants present in the mRNA samples.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: January 30, 2018
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Igor Vilfan, Stephen Turner
  • Methods and Compositions for Delivery of Molecules and Complexes to Reaction Sites
    Publication number: 20180023134
    Abstract: The present invention provides methods, compositions, and systems for distributing molecules and complexes into reaction sites. In particular, the methods, compositions, and systems of the present invention result in an active loading of molecules and complexes into reaction sites with improved efficiency over loading by passive diffusion methods alone.
    Type: Application
    Filed: July 21, 2017
    Publication date: January 25, 2018
    Inventors: Jeremiah Hanes, Satwik Kamtekar, Yufeng Qian, Keith Bjornson, Thang Pham, David Rank, Paul Peluso, Erik Miller, Kristin Gleitsman, Leewin Chern, Steven Lin, Stephen Turner
  • Single-molecule capacitive nucleic acid sequencing with nanoscale electrode pairs
    Patent number: 9868987
    Abstract: Sequencing methods, devices, and systems are described. Arrays of nanoscale electronic elements comprising two electrodes separated by an insulating layer are used to provide sequence information about a template nucleic acid in a polymerase-template complex bound proximate to the insulating region. A sequencing reaction mixture comprising nucleotide analogs having impedance labels is introduced to the array of nanoscale electronic elements under conditions of polymerase mediated nucleic acid synthesis. The time sequence of incorporation of nucleotide analogs is determined by identifying the types of labels of the nucleotide analogs that are incorporated into the growing strand using measured impedance.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: January 16, 2018
    Assignee: Pacific Biosciences of California, Inc.
    Inventor: Stephen Turner
  • Ventilation System
    Publication number: 20170368247
    Abstract: An oxygenation system for a ventilation system comprises an inlet for receiving oxygenation gas at an oxygenation gas flow rate into an oxygenator, and an exhaust gas remover to remove exhaust gas at an exhaust gas flow rate from the oxygenator, and one or more flow controllers for controlling the exhaust gas flow rate relative to the oxygenation gas flow rate. This allows the amount of total gas entering the oxygenator and the amount of total gas removed from the oxygenator to be controlled with greater accuracy.
    Type: Application
    Filed: December 3, 2015
    Publication date: December 28, 2017
    Inventor: Stephen Turner
  • Control System
    Publication number: 20170361008
    Abstract: A control system controlling blood gas values in blood processed by an oxygenator, wherein the oxygenator generates arterial blood by exposing venous blood to oxygen from an oxygenation gas supply, comprises a monitoring arrangement to determine a level of the blood gas values in the arterial blood and a controller that is responsive to the monitoring arrangement and configured to control parameters of the oxygenation gas supply to the oxygenator. This allows the blood gas values to be adjusted toward a pre-determined level.
    Type: Application
    Filed: December 3, 2015
    Publication date: December 21, 2017
    Inventor: Stephen Turner
  • Pump Tube Retention Mechanism
    Publication number: 20170354814
    Abstract: A clamp arrangement for retaining a flexible tube (18) during operation of a roller pump (10) for pumping fluid, the clamp arrangement comprising a pair of rotatable bobbins (24A, 24B, 26A, 26B) mounted adjacent to each other. Each bobbin (24A, 24B, 26A, 26B) has a tapered groove (30), formed partially around a cylindrical surface of the bobbin (24A, 24B, 26A, 26B), and counter rotation of the bobbins (24A, 24B, 26A, 26B) clamps the tube 18 between the bobbins (24A, 24B, 26A, 26B) in the tapered grooves (30). The clamp arrangement allows tubes of different shapes and diameters to be securely held without overly deforming the tube.
    Type: Application
    Filed: January 8, 2016
    Publication date: December 14, 2017
    Inventor: Stephen Turner
  • INTERMITTENT DETECTION DURING ANALYTICAL REACTIONS
    Publication number: 20170342481
    Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.
    Type: Application
    Filed: June 23, 2017
    Publication date: November 30, 2017
    Inventors: Stephen Turner, Jon Sorenson, Kenneth Mark Maxham, John Eid
  • APPARATUS AND METHOD FOR PERFORMING NUCLEIC ACID ANALYSIS
    Publication number: 20170343479
    Abstract: The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.
    Type: Application
    Filed: June 8, 2017
    Publication date: November 30, 2017
    Inventors: Stephen Turner, Jonas Korlach
  • Integrated analytical system and method
    Patent number: 9822410
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: November 21, 2017
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Sr., Scott Edward Helgesen
  • PROVISIONING DEVICES USING NEAR-FIELD COMMUNICATION
    Publication number: 20170317720
    Abstract: Disclosed are various examples for provisioning a client device through near-field communication (NFC). An administrator device can provide configuration parameters to a client device in a factory-reset condition through an NFC bump. A second NFC bump can be performed that provides enrollment parameters to the client device, after which the client device can complete enrollment with an enterprise mobility management (EMM) service.
    Type: Application
    Filed: April 29, 2016
    Publication date: November 2, 2017
    Inventors: Stephen Turner, Scott Kelley
  • Cardioplegic Agent Delivery System
    Publication number: 20170304523
    Abstract: A cardioplegic agent delivery system comprises a syringe pump for providing cardioplegic agent into a carrier fluid of a perfusion system, a flow sensor for sensing a flow of the carrier fluid, and an interlock responsive to the flow sensor. The interlock prevents operation of the syringe pump in the absence of carrier fluid flow sensed by the flow sensor. This provides increased safety in a cardioplegic agent delivery system.
    Type: Application
    Filed: November 10, 2015
    Publication date: October 26, 2017
    Inventor: Stephen Turner
  • DETECTING VULNERABILITIES IN MANAGED CLIENT DEVICES
    Publication number: 20170286689
    Abstract: Various examples relate to detecting vulnerabilities in managed client devices. In some examples, a system determines whether a vulnerability scan of a computing device is required to be performed. The system installs a vulnerability detection component in the computing device in response to determining that the vulnerability scan is required to be performed. The system requests the vulnerability detection component to perform the vulnerability scan of the computing device. The system transmits a result of the vulnerability scan to a remote management service for the computing device.
    Type: Application
    Filed: March 30, 2016
    Publication date: October 5, 2017
    Inventors: Scott Harlow Kelley, Adarsh Subhash Chandra Jain, Stephen Turner
  • ASSOCIATING USER ACCOUNTS WITH ENTERPRISE WORKSPACES
    Publication number: 20170289128
    Abstract: Various examples relate to the configuration of enterprise workspaces that can be provided in computing devices. In some examples, a computing device is enrolled with a management service that controls operation of at least a portion of the computing device. A management component creates a user account with a distributor of the operating system based on an email address. The management component requests an authentication service to authenticate a user. The user account is associated with an enterprise workspace of the computing device.
    Type: Application
    Filed: March 30, 2016
    Publication date: October 5, 2017
    Inventors: Scott Harlow Kelley, Adarsh Subhash Chandra Jain, Stephen Turner
  • CONFIGURING ENTERPRISE WORKSPACES
    Publication number: 20170288959
    Abstract: Various examples relate to the configuration of enterprise workspaces that can be provided in computing devices. In some examples, a computing device is enrolled with a management service that controls operating of at least a portion of the computing device. A management component creates a user account with a distributor of the operating system based on an email address and a password. The user account is associated with an enterprise workspace of the computing device.
    Type: Application
    Filed: March 30, 2016
    Publication date: October 5, 2017
    Inventors: Scott Harlow Kelley, Adarsh Subhash Chandra Jain, Stephen Turner
  • Nanopore sequencing using N-mers
    Patent number: 9772323
    Abstract: The invention relates to devices and methods for nanopore sequencing. The invention provides for using the signals from N monomeric units (n-mers) within the nanopore to provide sequence information. The invention includes substrates having arrays of nanopores with incorporated electronic circuits, for example, in semiconductor substrates. In some cases, the arrays of nanopores reside in discrete reservoirs.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: September 26, 2017
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Stephen Turner, Benjamin Flusberg
  • NANOSCALE APERTURES HAVING ISLANDS OF FUNCTIONALITY
    Publication number: 20170253480
    Abstract: Methods, compositions and arrays for non-random loading of single analyte molecules into array structures are provided. Arrays of confined regions are produced wherein each confined region comprises a single island within the confined region. The island can be selectively functionalized with a coupling agent to couple a single molecule of interest within the confined region.
    Type: Application
    Filed: March 24, 2017
    Publication date: September 7, 2017
    Inventors: Stephen Turner, Ron Kuse, Gregory Kearns, Pezhman Monadgemi, Mathieu Foquet, Drew Martinez
  • PROVISIONING OF APPLICATIONS DEPLOYED ON CLIENT DEVICES
    Publication number: 20170250977
    Abstract: Disclosed are various examples for deploying applications on client devices through a management service. A client device can be enrolled with a management service. The management service can determine application settings that are associated with an application and generate an application profile for the application. The application profile can be used to deploy the application to client devices and provision the application with the appropriate application settings.
    Type: Application
    Filed: February 29, 2016
    Publication date: August 31, 2017
    Inventors: Stephen Turner, Scott Kelley
  • Real-time analytical methods and systems
    Patent number: 9746476
    Abstract: The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions, and for determining various characteristics of the different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to stimulate, enhance, or inhibit such reactions.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: August 29, 2017
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Jonas Korlach, Stephen Turner, Benjamin Flusberg, Mark Chaisson, Eric Schadt, Jeffrey Wegener
  • Nucleic acid sequence analysis
    Patent number: 9738929
    Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: August 22, 2017
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Stephen Turner, Jon Sorenson, Kenneth Mark Maxham, John Eid, Cheryl Heiner, Kevin Travers
  • CLASSIFICATION OF NUCLEIC ACID TEMPLATES
    Publication number: 20170233802
    Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
    Type: Application
    Filed: September 28, 2016
    Publication date: August 17, 2017
    Inventors: Benjamin Flusberg, Stephen Turner, Jon Sorenson, Kevin Travers, Cheryl Heiner