Patents by Inventor Stephen W. Byers

Stephen W. Byers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CADHERIN-11 INHIBITOR FORMULATION AND ITS USES IN IMMUNOTHERAPY
    Publication number: 20230210849
    Abstract: Provided herein are compositions and methods for the treatment and prevention of cadherin-11 (CDH11) related diseases. The compositions include CDH11 inhibitors that are formulated for use in combination with chemotherapy and/or immunotherapy, to treat or prevent cancer, fibrosis, and autoimmune diseases.
    Type: Application
    Filed: June 4, 2021
    Publication date: July 6, 2023
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Sivanesan DAKSHANAMURTHY, Ivana PERAN, Stephen W. BYERS, Shahin ASSEFNIA
  • Treating melanoma with mebendazole and a mitogen-activated kinase inhibitor
    Patent number: 11179395
    Abstract: Provided herein are methods for treating melanoma in a subject.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: November 23, 2021
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Sivanesan Dakshanamurthy, Stephen W. Byers, Dean Rosenthal
  • Predicting drug-target interactions and uses for drug repositioning and repurposing
    Patent number: 10916331
    Abstract: Described herein are methods of predicting drug-target interactions and methods of using the information for drug repurposing. The methods described herein combine different descriptors, including, for example, atom pair similarity, shape, topology and chemical signatures, physico-chemical functional descriptors, contact points of the ligand and the target protein, chemical similarity, and docking score.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: February 9, 2021
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Sivanesan Dakshanamurthy, Stephen W. Byers
  • TREATING MELANOMA WITH MEBENDAZOLE AND A MITOGEN-ACTIVATED KINASE INHIBITOR
    Publication number: 20180263987
    Abstract: Provided herein are methods for treating melanoma in a subject.
    Type: Application
    Filed: March 16, 2018
    Publication date: September 20, 2018
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Sivanesan Dakshanamurthy, Stephen W. Byers, Dean Rosenthal
  • PREDICTING DRUG-TARGET INTERACTIONS AND USES FOR DRUG REPOSITIONING AND REPURPOSING
    Publication number: 20180157786
    Abstract: Described herein are methods of predicting drug-target interactions and methods of using the information for drug repurposing. The methods described herein combine different descriptors, including, for example, atom pair similarity, shape, topology and chemical signatures, physico-chemical functional descriptors, contact points of the ligand and the target protein, chemical similarity, and docking score.
    Type: Application
    Filed: June 3, 2016
    Publication date: June 7, 2018
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Sivanesan Dakshanamurthy, Stephen W. Byers
  • Cadherin-11 inhibitors and methods of use thereof
    Patent number: 9889131
    Abstract: Cadherin-11 inhibitors and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: February 13, 2018
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Stephen W. Byers, Sivanesan Dakshanamurthy, Jaime M. Guidry Auvil, Milton L. Brown
  • Cadherin-11 Inhibitors and Methods of Use Thereof
    Publication number: 20160151363
    Abstract: Cadherin-11 inhibitors and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis.
    Type: Application
    Filed: February 5, 2016
    Publication date: June 2, 2016
    Applicant: Georgetown University
    Inventors: Stephen W. Byers, Sivanesan Dakshanamurthy, Jaime M. Guidry Auvil, Milton L. Brown
  • Substituted pyrazines as cadherin-11 inhibitors
    Patent number: 9284368
    Abstract: This invention provides for a method of preventing or treating a cadherin-11 related disease in a subject, which includes administering to the subject an effective amount of a compound of the following formula: or a pharmaceutically acceptable salt or prodrug thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, X1 and X2 are as defined herein.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: March 15, 2016
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Stephen W. Byers, Sivanesan Dakshanamurthy, Jaime M. Guidry Auvil, Milton L. Brown
  • Small molecule inhibitors of AGBL2
    Patent number: 9199918
    Abstract: Small molecule inhibitors of AGBL2 are provided, as well as methods of using the inhibitors to treat or prevent cancer and neurologic disorders.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: December 1, 2015
    Assignee: Georgetown University
    Inventors: Stephen W. Byers, Sivanesan Dakshanamurthy, Ziad Sahab
  • METHOD FOR PREDICTING DRUG-TARGET INTERACTIONS AND USES FOR DRUG REPOSITIONING
    Publication number: 20150324546
    Abstract: Described herein are methods of predicting drug-target interactions and method of using the information for drug repurposing. The methods described herein combine different descriptors including, for example, shape, topology and chemical signatures, physico-chemical functional descriptors, contact points of the ligand and the target protein, chemical similarity, and docking score.
    Type: Application
    Filed: June 21, 2013
    Publication date: November 12, 2015
    Inventors: Sivanesan Dakshanamurthy, Stephen W. Byers
  • Cadherin-11 Inhibitors and Methods of Use Thereof
    Publication number: 20150064168
    Abstract: Cadherin-11 inhibitors and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis.
    Type: Application
    Filed: July 3, 2014
    Publication date: March 5, 2015
    Inventors: Stephen W. Byers, Sivanesan Dakshanamurthy, Jaime M. Guidry Auvil, Milton L. Brown
  • Cadherin-11 inhibitors and methods of use thereof
    Patent number: 8802687
    Abstract: Cadherin-11 inhibitors, including 4-(2-phenylpyridin-3-yl)phenol, and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: August 12, 2014
    Assignee: Georgetown University
    Inventors: Stephen W. Byers, Sivanesan Dakshanamurthy, Jaime M. Guidry Auvil, Milton L. Brown
  • SMALL MOLECULE INHIBITORS OF AGBL2
    Publication number: 20130331328
    Abstract: Small molecule inhibitors of AGBL2 are provided, as well as methods of using the inhibitors to treat or prevent cancer and neurologic disorders.
    Type: Application
    Filed: February 14, 2012
    Publication date: December 12, 2013
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Stephen W. Byers, Sivanesan Dakshanamurthy, Ziad Sahab
  • CADHERIN-11 INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20120128693
    Abstract: Cadherin-11 inhibitors and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis.
    Type: Application
    Filed: February 9, 2010
    Publication date: May 24, 2012
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Stephen W. Byers, Sivanesan Dakshanamurthy, Jaime M. Guidry Auvil, Milton L. Brown