Abstract: A device for controllably restricting flow through a resilient tube including a block and a pair of generally J-shaped leg members pivotally mounted to the block. The leg members, when pivoted together, together provide a tube support surface. The block is formed with a bore in which there is a rotatable internally threaded sleeve. A jaw member having a threaded shaft is threadedly mated to the sleeve and a knob is fixedly secured to the sleeve for rotation therewith. Accordingly, rotation of the knob moves the jaw member toward and away from the tube support surface to provide desired compression to a length of resilient tubing captured between the jaw and the tube support surface. By pivoting the leg members away from each other, space is provided for installation of the flow restriction device at any desired point along the length of the tubing.

Abstract: A device for controllably restricting flow through a resilient tube including a block and a pair of generally J-shaped leg members pivotally mounted to the block. The leg members, when pivoted together, together provide a tube support surface. The block is formed with a bore in which there is a rotatable internally threaded sleeve. A jaw member having a threaded shaft is threadedly mated to the sleeve and a knob is fixedly secured to the sleeve for rotation therewith. Accordingly, rotation of the knob moves the jaw member toward and away from the tube support surface to provide desired compression to a length of resilient tubing captured between the jaw and the tube support surface. By pivoting the leg members away from each other, space is provided for installation of the flow restriction device at any desired point along the length of the tubing.

Abstract: A collar for a connection between a resilient tube and a rigid barbed connector. The collar comprises a generally cylindrical sleeve member having interior annular ridges. When the collar is installed on the tube surrounding the barbed connector, the ridges press into the tube and prevent expansion of the tube to prevent leakage between the tube and the connector.

Abstract: A collar for a connection between a resilient tube and a rigid barbed connector. The collar comprises a generally cylindrical sleeve member having interior annular ridges. When the collar is installed on the tube surrounding the barbed connector, the ridges press into the tube and prevent expansion of the tube to prevent leakage between the tube and the connector.

Abstract: An assembly and a method for providing a sterile connection between a vessel and a bag. The assembly includes a previously sterilized bag connected to tubing which is clamped closed. The tubing is connected to the vessel. The vessel and the tubing distally of the clamp are sterilized together. The clamp is then opened to allow material to pass from the vessel to the bag in a sterile environment.

Abstract: A system for permanently associating identifying indicia with a previously manufactured product. Silicone sheet material having imbedded therein a quantity of thermally activatable crosslinking catalyst is secured to the product. An indici-containing element is placed on the silicone sheet material and is then covered by another piece of the same type of silicone sheet material. Heat is then applied to the assembly to cause the pieces of silicone sheet material to crosslink together and encapsulate the indicia-containing element.

Abstract: A system for permanently associating identifying indicia with a previously manufactured product. Silicone sheet material having imbedded therein a quantity of thermally activatable crosslinking catalyst is secured to the product. An indicia-containing element is placed on the silicone sheet material and is then covered by another piece of the same type of silicone sheet material. Heat is then applied to the assembly to cause the pieces of silicone sheet material to crosslink together and encapsulate the indicia-containing element.

Abstract: Apparatus for forming a bag assembly from a tube and a tubular flexible membrane operates in accordance with a four step process. This process includes the steps of clamping the tube within an open end of the membrane, injecting liquid adhesive into the open end of the membrane, clamping the membrane and tube where the adhesive was injected, and heating and curing the assembly.

Abstract: An apparatus and method for the sterilization-in-place of a bag assembly includes rigid bag and tube support members arranged in a clamshell configuration to surround and support the bag assembly so that pressurized steam can be supplied to the interior of the bag assembly without the danger of rupture.

Abstract: A method for forming, in a single step, a silicone manifold interconnecting a plurality of silicone tubes is performed by providing a silicone insert piece having a network of interior channels dimensioned the same as the silicone tube interiors. Solid non-silicone plugs are inserted into the insert piece and the ends of the silicone tubes and the resulting assembly is placed in a mold cavity. Liquid silicone is added to the mold cavity and is then heated and cured to form the desired manifold interconnecting the tubes. The manifold is then removed from the mold and a source of pressurized air is used to blow out the plugs.

Abstract: A method for forming a fitting at an end of a braid-reinforced silicone tube. A short length of the outer layer surrounding the braiding is removed and the exposed braiding is folded back over a first silicone ring and then a second silicone ring is placed over the folded-over braiding. The end of the tube is then placed in a mold which is then filled with liquid silicone. After the silicone is heated and cured, a unitary structure of tube and fitting results. Since the braiding is part of the unitary structure, it cannot be pulled out, thereby increasing the reliability of tube and fitting.

Abstract: The combination of a bag and tubes connected thereto for use in pharmaceutical manufacturing and for holding health care related solutions is formed entirely of silicone. This avoids the previous problem of the releasing into the held fluids of plasticizers or plastic additives contained in the PVC material making up prior bags.