Abstract: Provided is a compound of formula I, or pharmaceutically acceptable salt or solvate thereof, as defined herein for use in the treatment or prevention of a Dirofilaria infection in a mammal, The compounds are also for use in the treatment or prevention of diseases or conditions caused by a Dirofilaria infection in a mammal. Also described are corresponding methods of treating or preventing a Dirofilaria infection in a mammal.

Abstract: The present invention relates to compounds of Formulae I and II as defined herein, and salts and solvates thereof. The present invention also relates to pharmaceutical compositions comprising compounds of Formulae I and II, and to the use of compounds of Formulae I and II in the treatment or prevention of filarial worm infection, as well as other diseases or conditions in which filarial worm infection is implicated.

Abstract: The present invention relates to compounds of Formulae (I) and (II) as defined herein, and salts and solvates thereof. The present invention also relates to pharmaceutical compositions comprising compounds of Formulae (I) and (II), and to the use of compounds of Formulae (I) and (II) in the treatment or prevention of filarial worm infection, as well as other diseases or conditions in which filarial worm infection is implicated.

Abstract: Methods for providing a plurality of convenience kits for sterilizing and delivering a quantity of medicine into the safety of a sterile chamber inside closed system (which can be disposed in a potentially contaminating field environment) are disclosed for container filling applications including Avastin. fortified antibiotic eye drops, mitomycin and hazardous drugs, in general. The containers can include medical syringes, eye drop bottles, vials and product quality assurance containers. A syringe needle cap effective in containment of fluids dispensed from a syringe while being primed is also disclosed.

Abstract: A deceleration mechanism for a door system. In particular, a door system that is adapted to control an opening of a door module that separates compartments of an aircraft, the door module comprising a door panel that performs a rotational movement above a floor structure of the aircraft during an opening of the door module, comprises a deceleration mechanism that comprises a bolt, a bolt moving mechanism that is attached to the bolt, a latch mechanism that is removably connected to the bolt moving mechanism an activation mechanism that is attached to the latch mechanism, and a brake element that is rigidly attached to the bolt.

Abstract: A monitoring device wearable by a person to be monitored, comprising: one or more sensing means for sensing cardio, respiratory, physiological and/or other information from the person; processing means for analysing the sensed information; memory means for storing the sensed and/or analysed information; and communication means for transmitting at least the analysed information. At least one waveform acquired from the sensed cardio, respiratory, physiological and/or other information is digitised in real time; analysis of the sensed and/or digitised information is performed in real-time and a welfare indication of the person computed in real-time; and the computed welfare indication of the person is transmitted by the communication means and/or stored in the memory means.

Abstract: A door system with a deceleration mechanism may be adapted to control an opening of a door module that separates compartments of an aircraft and includes a door panel and a door frame. During the opening of the door module, the door panel performs a rotational movement 389 above a floor structure of the aircraft. The deceleration mechanism is operable in a normal operation mode and a deceleration mode and comprises a hinge, a wedge-shaped component that is rotatably attached to the hinge, and an activation device. The activation device is coupled to the wedge-shaped component and switches the deceleration mechanism from operating in the normal operation mode to operating in the deceleration mode when a difference in pressure between the compartments exceeds a predetermined threshold.

Abstract: Systems, methods, devices, and apparatus for detecting sample defects in blood samples processed in automated processing systems are described herein. One aspect describes an automated blood sample processing apparatus having a pre-analytic specimen integrity monitoring device. Another aspect describes devices, systems, and methods for identifying blood components and properties in blood samples. Further aspects relate to systems and methods for setting reference ranges for sample defects and interference in blood samples. Additionally, devices, systems, and methods for identifying defective samples are described.

Abstract: Systems, methods, devices, and apparatus for detecting sample defects in blood samples processed in automated processing systems are described herein. One aspect describes an automated blood sample processing apparatus having a pre-analytic specimen integrity monitoring device. Another aspect describes devices, systems, and methods for identifying blood components and properties in blood samples. Further aspects relate to systems and methods for setting reference ranges for sample defects and interference in blood samples. Additionally, devices, systems, and methods for identifying defective samples are described.

Abstract: A door opening system with a deceleration mechanism may be adapted to control an opening of a door module that includes a door panel and a door frame. Deceleration mechanism may include strap that connects door panel with door frame, spool, and spool. Spool may receive one end of strap, is biased to roll up a first portion of strap, and adapted to perform a first unwinding of the first portion of strap. Spool may receive a second end of strap, is biased to roll up a second portion of strap, and adapted to perform a second unwinding of the second portion of strap from spool. Spool may include a braking apparatus that is adapted to decelerate the second unwinding when a velocity of the second unwinding is above a predetermined threshold.

Abstract: Methods and systems of malware detection in distributed computer systems. An example method includes: receiving, by a network router, a network packet originated by a client computer; matching the network packet to a default route; forwarding the network packet to a command and control server simulator; and forwarding, to the client computer system, one or more response packets comprising a command and control instruction issued to the client computer system by the command and control server simulator.

Abstract: The present invention relates to a combination therapeutic product comprising one or more respiratory electron transport chain inhibitors and a cytochrome bd inhibitor, as defined herein, or a pharmaceutically acceptable salt thereof. The present invention also relates to pharmaceutical compositions comprising the combination therapeutic product and to the use of the combination therapeutic product in the treatment of mycobacterial infections, such as tuberculosis.

Abstract: Embodiments of an apparatus of the present invention generally include a tubular, substantially exteriorly rectangular, jumper tube connector having a substantially rectangular interior cavity having a plurality of transverse grooves disposed in the surface thereof and extending there around, wherein at least a portion of the jumper tube connector along its two opposing wide sides has a non-uniform wall thickness, at least a portion of which being thicker than a substantially uniform wall thickness of the connector's two opposing narrow sides. A method of connecting shunt tubes utilizing the apparatus is also provided.

Abstract: A door system with a deceleration mechanism may be adapted to control an opening of a door module that separates compartments of an aircraft and includes a door panel and a door frame. During the opening of the door module, the door panel performs a rotational movement 389 above a floor structure of the aircraft. The deceleration mechanism is operable in a normal operation mode and a deceleration mode and comprises a hinge, a wedge-shaped component that is rotatably attached to the hinge, and an activation device. The activation device is coupled to the wedge-shaped component and switches the deceleration mechanism from operating in the normal operation mode to operating in the deceleration mode when a difference in pressure between the compartments exceeds a predetermined threshold.

Abstract: A deceleration mechanism for a door system. In particular, a door system that is adapted to control an opening of a door module that separates compartments of an aircraft, the door module comprising a door panel that performs a rotational movement above a floor structure of the aircraft during an opening of the door module, comprises a deceleration mechanism that comprises a bolt, a bolt moving mechanism that is attached to the bolt, a latch mechanism that is removably connected to the bolt moving mechanism an activation mechanism that is attached to the latch mechanism, and a brake element that is rigidly attached to the bolt.

Abstract: A method for evaluating adherence to funding rules includes: storing transaction data entries, each including a controlled payment number (CPN), a merchant category code, transaction date, and transaction data, where the CPN is subject to a first spend control setting a maximum spend amount during a predetermined time interval; identifying a group of transaction data entries that includes a transaction date within a predetermined period of time; identifying a subset of the group of transaction data entries where the merchant category code is one of a set indicated in a funding adherence rule; determining an adherence score for the CPN based on a ratio of a number of transaction data entries in the subset to a number of transaction data entries in the group; and modifying the first spend control to adjust the maximum spend amount based on the adherence score and funding adherence rule.

Abstract: A door locking system for a door module that separates compartments in an aircraft. Door locking system has locking element that is adapted to maintain door panel of door module in a closed position. Door locking system further includes first and second mechanisms that are adapted to release door panel from the closed position in a normal and an abnormal mode, respectively. Second mechanism is spatially segregated from and operates independently of first mechanism. Second mechanism includes locking element release actuator, pressure sensor, and controller that directs locking element release actuator to act on locking element when pressure sensor detects a difference in pressure between the compartments that exceeds a predetermined threshold.

Abstract: An aircraft with a plurality of aircraft doors, each aircraft door comprising at least one lock lever that is provided for engaging a counterpart in an engaged state for locking a respective aircraft door relative to the aircraft, wherein a real-time monitoring device is provided for generating a real-time representation of the at least one lock lever and the counterpart, the real-time representation being suitable for determining whether the at least one lock lever is in the engaged state.

Abstract: An actuatable emergency exit door with a door actuating device that comprises at least two connection rods that are pivotally mountable to an associated structural frame that is adapted for accommodating the actuatable emergency exit door in closed state, the at least two connection rods being provided for enabling an opening movement of the actuatable emergency exit door with respect to the associated structural frame during opening, wherein at least one door-mounted goose neck-shaped structure is mountable to the associated structural frame for enabling an initial translational opening movement and subsequently a swiveling opening movement of the actuatable emergency exit door with respect to the associated structural frame during opening. The invention is further related to an aircraft or space craft with a pressurized cabin having such an actuatable emergency exit door.

Abstract: Methods and systems of malware detection in distributed computer systems. An example method includes: receiving, by a network router, a network packet originated by a client computer; matching the network packet to a default route; forwarding the network packet to a command and control server simulator; and forwarding, to the client computer system, one or more response packets comprising a command and control instruction issued to the client computer system by the command and control server simulator.