Abstract: Associating multiple content chunks with multiple DVD packages or media objects; conveniently viewing or resuming these content chunks without knowing their disposition. Associating content chunks with media objects and positions therein, associating requests by a user for play or resumption of play with appropriate behaviors, including a database. Media objects have unique media hash values, to associate content chunks with hash values, and positions within media objects maintained by bookmarks and watchpoints. Selecting a content chunk might cause its metadata to be presented, or might cause selectable content chunks within that content chunk to become selectable. Users requesting play or resumption of play of content chunks, might cause those content chunks, or might cause smaller content chunks, such as movies, to be presented. Content chunks might span more than one media object, or might switch back and forth among multiple media objects, each without the viewer needing to know.

Abstract: The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.

Abstract: Selection and presentation of media streams, in which presentation is not limited by order imposed by the digital content representative of those media streams, in response to bookmarks and watchpoints settable and usable by a user. Bookmarks reference a location within the media stream, not necessarily pre-selected and possibly dynamically selected, in which a presentation can be started or restarted therefrom. Watchpoints reference a location within the media stream, or a presentation state for the media stream, in which an action can be triggered thereby. Bookmarks and watchpoints provide a general technique for presenting selections from media streams in response to metadata.

Abstract: Secure presentation of media streams includes encoding the media streams into digital content, encrypting a portion of that digital content, the portion being required for presentation, in which the encrypted version is substantially unchanged in formatting parameters from the clear version of the digital content. Selecting those portions for encryption so there is no change in distribution of the media stream: packetization of the digital data, or synchronization of audio with video portions of the media stream. When encoding the media stream into MPEG-2, refraining from encrypting information by which the video block data is described, packet formatting information, and encrypting the video block data using a block-substitution cipher. A block-substitution cipher can be used to encrypt each sequence of 16 bytes of video data in each packet, possibly leaving as many as 15 bytes of video data in each packet in the clear.

Abstract: The invention provides a method of recovering from de-synchronization attacks includes registering original and altered digital content using nonlinear transformations to iteratively attempt to provide better-approximated registration. Approximation occurs at more than one level of granularity, by selecting among a greater number of possible transformation functions at each step. Transformations and comparisons might be conducted directly on pixel values, on coefficients for a set of basis wavelets, or on some transformation of the original and altered digital content. A human operator might assist this process, such as by suggesting transformations or providing evaluation of the degree of registration. Upon resynchronization, embedded identifying information in the original digital content is recovered.

Abstract: A technique of distributing digital content representing media streams, and keys for unlocking that content, to a user. Content is deliverable to the user separately from licenses to that content. Content is delivered encrypted. Licenses are delivered designating selected presentation devices owned by the user. The presentation devices include a secure portion, relatively resistant to tampering by the user, in which each presentation device maintains a unique presentation device key. The user owns one or more such presentation devices, coupled using a local communication link to a local library, which maintains a copy of the content in an encrypted form. The user can search the library for information generally available about the media stream.

Abstract: A method of embedding information in digital content representing media streams. The method includes (1) selecting a set of locations within that digital content reprensenting the media stream to embed information, (2) selecting a set of possible alterations to make at those locations, and (3) making a subset of the possible alterations. The set of locations and possible alterations is herein sometimes called a “watermark.” The subset of actual alterations that are made is herein sometimes called a “fingerprint.

Abstract: Distributing information, including the steps of watermarking the digital content, distributing the digital content using a multi-source system, and partially fingerprinting digital content at each stage of moving information from a point of origin to the viewer. “Adaptation” of the digital content to the recipient includes maintaining the digital content in encrypted form at each such intermediate device, including decrypting the digital content with a key unique to both the device and the specific movie, selecting a portion of the watermark locations into which to embed information, embedding fingerprinting information into those locations sufficient to identify the recipient, and encrypting the fingerprinted digital content with a new such key.

Abstract: Embedding fingerprinting or watermarking information includes delivering information in-band within digital content representing a media stream, so unauthorized distributors must choose between degrading the media stream, or leaving sufficient information detectable that unauthorized distribution can be detected. For fingerprinting, the method provides a relatively high degree of confidence of both detecting at least one colluding unauthorized distributor, and not falsely accusing any innocent party of being an unauthorized distributor. Embedding fingerprinting or watermarking information includes selecting a sequence of locations within digital content, and embedding information in the form of a sequence of one or more bits at each of those locations, thus representing a set of marking symbols.

Abstract: The invention relates to a novel class of amide derivatives which act as thrombin inhibitors as described by formula (I), where R1 and R2, independently represent a group (a) or R1 and R2 together form a C3-7 heterocycloalkyl or heterocycloalkenyl group which may be optionally substituted by C1-6 alkyl, C1-4 alkoxy, halogen, carboxylic acid or a C1-4 carboxylic acid ester group; R3 represents hydrogen, C1-3 alkyl, halogen, or C1-2 alkoxy; R4, R5 and R6 independently represent hydrogen, or halogen; R7 represents hydrogen or C1-6 alkyl; R8 represents hydrogen, C3-7 cycloalkyl, C3-7 cycloalkenyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkenyl, aryl or heteroaryl, which groups are optionally substituted by one or more groups selected from halogen, hydroxy, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 acyloxy, NR9R10, NHCOR11, NHSO2R12, COR13, CO2R14, CONR15R16, and SO2NHR17; X represents a bond, a C1-6 alkyl chain, or a C3-6 alkenyl chain, where one or two nitrogen, oxygen, or sulfur atoms may be optionally contained within

Abstract: This invention is directed to cryopreservation of harvested mammalian tissues and living cultured tissue equivalents made by in vitro technology. The invention involves immersing a mammalian tissue or cultured tissue equivalent in a cryoprotectant solution, agitating the cryoprotectant solution and the immersed tissue to achieve effective penetration of the cryoprotectant solution into the tissue, and then freezing the tissue at a very slow freezing rate at 0.3.degree. C. or less/min. In the freezing step, extracellular ice formation is initiated by seeding. The cryopreserved tissue may be stored for indefinite periods of time prior to use. The cultured tissue equivalent is an in vitro model of the equivalent human tissue, such as skin or cornea, which, when retrieved from storage can be used for transplantation or implantation in vivo or for screening compounds in vitro.

Abstract: An environmentally degradable polymer based composition which has been exposed to actinic or ionizing radiation and which comprises an ethylene polymer base resin, and a synergistic combination of an auto-oxidative polymer or low molecular weight organic compound, certain polyvalent metal salts, and an antioxidant additive for the ethylene polymer; and a process for making such composition.

Abstract: An environmentally degradable polymer composition comprising an ethylene polymer base resin, and a synergistic combination of an auto-oxidative polymer or low molecular weight organic compound; certain polyvalent transition metal salt; and an antioxidant additive for the ethylene polymer. A product of this composition when discarded to the environment is caused to deteriorate by the action of the elements, thereby hastening the deterioration of litter.