Patents by Inventor Stephen Weber
Stephen Weber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250035629Abstract: The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being MR-proADM, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: sFlt-1, GDF15 and ESM1, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation.Type: ApplicationFiled: September 28, 2022Publication date: January 30, 2025Inventors: Felix Gruenewald, Victor Johann Raul Jeger, Martin Klammer, Philipp Schuetz, Maria von Holtey, Stephen Weber, Heike Wegmeyer, Ursula-Henrike Wienhues-Thelen
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Publication number: 20240248098Abstract: The present invention concerns the field of diagnostics. Specifically. it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject. said first biomarker being NGAL. determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: HBP (Heparin-binding protein). Aspartate aminotransferase. Bilirubin. Alanine aminotransferase. ESM-1 and a BNP-type peptide. comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers. and assessing said subject based on the comparison and/or the calculation. The invention also relates to the use of a first biomarker being NGAL and a second biomarker selected from the group consisting of: HBP (Heparin-binding protein). Aspartate aminotransferase. Bilirubin.Type: ApplicationFiled: April 29, 2022Publication date: July 25, 2024Inventors: Felix Gruenewald, Victor Johann Raul Jeger, Martin Klammer, Philipp Schuetz, Maria von Holtey, Stephen Weber, Heike Wegmeyer, Ursula-Henrike Wienhues-Thelen
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Publication number: 20240230676Abstract: The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being ESM-1, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is Creatinine or a Cystatin C, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation. The invention also relates to the use of a first biomarker being ESM-1 and a second biomarker being Creatinine or a Cystatin C or a detection agent specifically binding to said first biomarker and a detection agent specifically binding to said second biomarker for assessing a subject with suspected infection.Type: ApplicationFiled: April 29, 2022Publication date: July 11, 2024Inventors: Felix Gruenewald, Victor Johann Raul Jeger, Martin Klammer, Philipp Schuetz, Maria von Holtey, Stephen Weber, Heike Wegmeyer, Ursula-Henrike Wienhues-Thelen
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Publication number: 20240230675Abstract: The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being sFlt1, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: Cystatin C, IGFBP7, a cardiac Troponin, Creatinine, STREM1, PCT and Bilirubin, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation.Type: ApplicationFiled: April 29, 2022Publication date: July 11, 2024Inventors: Felix Gruenewald, Victor Johann Raul Jeger, Martin Klammer, Philipp Schuetz, Maria von Holtey, Stephen Weber, Heike Wegmeyer, Ursula-Henrike Wienhues-Thelen
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Publication number: 20240230672Abstract: The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being Presepsin, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: GDF-15, Creatinine, sFlt1, IGFBP7, sTREM1, Cystatin C and PSP (Pancreatic Stone Protein), comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation.Type: ApplicationFiled: April 29, 2022Publication date: July 11, 2024Inventors: Felix Gruenewald, Victor Johann Raul Jeger, Martin Klammer, Philipp Schuetz, Maria von Holtey, Stephen Weber, Heike Wegmeyer, Ursula-Henrike Wienhues-Thelen
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Publication number: 20240230673Abstract: The present invention relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being GDF-15, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: sFLT1, Cystatin C, IGFBP-7, Bilirubin, ESM-1, sTREM-1, Procalcitonin, cardiac Troponin, BNP-type peptide, Alanine aminotransferase, and Aspartate aminotransferase, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation.Type: ApplicationFiled: April 29, 2022Publication date: July 11, 2024Inventors: Felix Gruenewald, Victor Johann Raul Jeger, Martin Klammer, Philipp Schuetz, Maria von Holtey, Stephen Weber, Heike Wegmeyer, Ursula-Henrike Wienhues-Thelen
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Publication number: 20240230674Abstract: The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being STREM1, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: Aspartate aminotransferase, Bilirubin, ESM-1, HBP (Heparin-binding protein), a cardiac Troponin, Alanine aminotransferase, and IL6, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation.Type: ApplicationFiled: April 29, 2022Publication date: July 11, 2024Inventors: Felix Gruenewald, Victor Johann Raul Jeger, Martin Klammer, Philipp Schuetz, Maria von Holtey, Stephen Weber, Heike Wegmeyer, Ursula-Henrike Wienhues-Thelen
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Publication number: 20240219404Abstract: The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being IGFBP7, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: PCT, IL6, a cardiac Troponin, Albumin, CRP, Bilirubin, Ferritin, ESM-1, Aspartate aminotransferase, a BNP-type peptide, Alanine aminotransferase, Creatinine, and suPAR, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation.Type: ApplicationFiled: April 29, 2022Publication date: July 4, 2024Inventors: Felix Gruenewald, Victor Johann Raul Jeger, Martin Klammer, Philipp Schuetz, Maria von Holtey, Stephen Weber, Heike Wegmeyer, Ursula-Henrike Wienhues-Thelen
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Publication number: 20240221958Abstract: The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being PCT, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: a cardiac Troponin, Creatinine, a BNP-type peptide, sTREM1, ESM-1, Haptoglobin, Heparin binding protein (HBP) and Aspartate aminotransferase, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation.Type: ApplicationFiled: April 29, 2022Publication date: July 4, 2024Inventors: Felix Gruenewald, Martin Klammer, Stephen Weber, Heike Wegmeyer, Ursula-Henrike Wienhues-Thelen, Victor Johann Raul Jeger, Philipp Schuetz, Maria von Holtey
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Publication number: 20240219405Abstract: The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being IL-6, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is Creatinine or a cardiac Troponin, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation. The invention also relates to the use of a first biomarker being IL-6 and a second biomarker being a cardiac Troponin or Creatinine or a detection agent specifically binding to said first biomarker and a detection agent specifically binding to said second biomarker for assessing a subject with suspected infection.Type: ApplicationFiled: April 29, 2022Publication date: July 4, 2024Inventors: Felix Gruenewald, Victor Johann Raul Jeger, Martin Klammer, Philipp Schuetz, Maria von Holtey, Stephen Weber, Heike Wegmeyer, Ursula-Henrike Wienhues-Thelen
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Patent number: 11471674Abstract: Apparatuses and methods for electrokinetic transport of fluids to patients. Drug-containing solutions may be placed in vial-like reservoir, which is connected to an apparatus such as a traditional catheter or other device capable of holding a drug-containing solution. Instead of a vial-like reservoir, a doped infusion pad or a gel may be used as a source of the drug-containing solution. The reservoir and apparatus may thus be the same component. The methods and apparatuses disclosed herein may also be used to transport fluid alone to achieve a clinical effect. The apparatus is placed at the point of drug delivery. The counter-electrode may be placed in or on a patient. Current is passed from the reservoir to the counter-electrode. Through electrokinetic transport, drug-containing solution is delivered along a current path from the drug source to the counter-electrode. A hollow fiber catheter for use in electrokinetic transport is also disclosed.Type: GrantFiled: December 12, 2017Date of Patent: October 18, 2022Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Stephen Weber, Amir H. Faraji, Yifat Guy, Andrea Jaquins-Gerstl, Alec C. Valenta
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Patent number: 10922349Abstract: Features are disclosed for filtering and presenting specific portions of monitoring data associated with specific events. The features may include: (1) receiving time stamp information from delivery partner; (2) filtering or receiving filtered feed of monitoring data such as audio or video data; and (3) providing notification to a user including the specific portion of the monitoring data. Where the monitoring data is ambiguous or disrupted, the analysis may be offloaded to a manual review process to avoid false-positives.Type: GrantFiled: April 17, 2018Date of Patent: February 16, 2021Assignee: Amazon Technologies, Inc.Inventors: Wendy M. Harris, Muhammad Tanvir Anwar, Michael Ellsworth Bundy, Stephen Weber Crow, Ariel Grob Dos Santos, Brian A. Michalowski, Joshua Roth, Jamie Siminoff
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Publication number: 20190314740Abstract: A method comprising: introducing a sample volume into an inlet end of a liquid chromatography column, wherein the liquid chromatography column includes a focusing segment proximal to the inlet end of the liquid chromatography column and a separation segment proximal to an elute outlet of the liquid chromatography column; maintaining only the focusing segment at a first temperature as the sample is introduced into the focusing segment; and subsequently heating the focusing segment to a second temperature that is higher than the first temperature after the entire sample volume has been introduced into the focusing segment.Type: ApplicationFiled: June 19, 2019Publication date: October 17, 2019Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Stephen Weber, Stephen Robert Groskreutz, Anthony Robert Horner, Rachael-Anh Elizabeth Wilson
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Patent number: 10391421Abstract: A method of comprising: introducing a sample volume into an inlet end of a liquid chromatography column, wherein the liquid chromatography column includes a focusing segment proximal to the inlet end of the liquid chromatography column and a separation segment proximal to an elute outlet of the liquid chromatography column; maintaining only the focusing segment at a first temperature as the sample is introduced into the focusing segment; and subsequently heating the focusing segment to a second temperature that is higher than the first temperature after the entire sample volume has been introduced into the focusing segment.Type: GrantFiled: January 14, 2016Date of Patent: August 27, 2019Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Stephen Weber, Stephen Robert Groskreutz, Anthony Robert Horner, Rachael-Anh Elizabeth Wilson
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Publication number: 20180110976Abstract: Apparatuses and methods for electrokinetic transport of fluids to patients. Drug-containing solutions may be placed in vial-like reservoir, which is connected to an apparatus such as a traditional catheter or other device capable of holding a drug-containing solution. Instead of a vial-like reservoir, a doped infusion pad or a gel may be used as a source of the drug-containing solution. The reservoir and apparatus may thus be the same component. The methods and apparatuses disclosed herein may also be used to transport fluid alone to achieve a clinical effect. The apparatus is placed at the point of drug delivery. The counter-electrode may be placed in or on a patient. Current is passed from the reservoir to the counter-electrode. Through electrokinetic transport, drug-containing solution is delivered along a current path from the drug source to the counter-electrode. A hollow fiber catheter for use in electrokinetic transport is also disclosed.Type: ApplicationFiled: December 12, 2017Publication date: April 26, 2018Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Stephen Weber, Amir H. Faraji, Yifat Guy, Andrea Jaquins-Gerstl, Alec C. Valenta
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Patent number: 9872982Abstract: Apparatuses and methods for electrokinetic transport of fluids to patients. Drug-containing solutions may be placed in vial-like reservoir, which is connected to an apparatus such as a traditional catheter or other device capable of holding a drug-containing solution. Instead of a vial-like reservoir, a doped infusion pad or a gel may be used as a source of the drug-containing solution. The reservoir and apparatus may thus be the same component. The methods and apparatuses disclosed herein may also be used to transport fluid alone to achieve a clinical effect. The apparatus is placed at the point of drug delivery. The counter-electrode may be placed in or on a patient. Current is passed from the reservoir to the counter-electrode. Through electrokinetic transport, drug-containing solution is delivered along a current path from the drug source to the counter-electrode. A hollow fiber catheter for use in electrokinetic transport is also disclosed.Type: GrantFiled: January 10, 2013Date of Patent: January 23, 2018Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Stephen Weber, Amir H. Faraji, Yifat Guy, Andrea Jaquins-Gerstl, Alec C. Valenta
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Publication number: 20160206971Abstract: A method of comprising: introducing a sample volume into an inlet end of a liquid chromatography column, wherein the liquid chromatography column includes a focusing segment proximal to the inlet end of the liquid chromatography column and a separation segment proximal to an elute outlet of the liquid chromatography column; maintaining only the focusing segment at a first temperature as the sample is introduced into the focusing segment; and subsequently heating the focusing segment to a second temperature that is higher than the first temperature after the entire sample volume has been introduced into the focusing segment.Type: ApplicationFiled: January 14, 2016Publication date: July 21, 2016Applicant: University of Pittsburgh - of the Commonwealth System of Higher EducationInventors: Stephen Weber, Stephen Robert Groskreutz, Anthony Robert Horner, Rachael-Anh Elizabeth Wilson
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Publication number: 20140287243Abstract: A coating composition comprising a colloidal suspension comprising a fluoropolymer and fluorophilic particles in a liquid solvent, wherein the solvent comprises a fluorocarbon, a semifluorous material, or a combination thereof. Also disclosed is a substrate comprising a coated surface, wherein the coated surface comprises a fluorophilic silica particle doped—fluoropolymer film. Further disclosed is a method comprising fluorinating silica particles and preparing a colloidal suspension comprising a fluoropolymer and the fluorinated silica particles in a liquid solvent, wherein the solvent comprises a fluorocarbon, a semifluorous material, or a combination thereof.Type: ApplicationFiled: March 6, 2014Publication date: September 25, 2014Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Stephen Weber, Hong Zhang, Sijia Wang
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Publication number: 20110302839Abstract: An apparatus and method for cultivating plant material in an agricultural or horticultural controlled growth environment is provided. The method includes providing a plant material to by cultivated, generating light having a color temperature in the range with an electrodeless induction lamp, and exposing the plant material to the light for a sufficient amount of time to promote the desired plant growth outcome.Type: ApplicationFiled: November 22, 2010Publication date: December 15, 2011Applicant: 6062 Holdings, LLCInventors: ERIC SENDERS, Cary Senders, Mathew Geschke, T. Stephen Weber