Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with calcium release-activated calcium channels (CRAC).

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein A, D, E, G, J, X, Y, Z R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.

Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) 1

Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) 1

Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonist, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

Abstract: This invention relates to certain piperidine quaternary salts of Formula (I) ##STR1## that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

Abstract: A primocane bearing cultivar of red raspberry designated "Joe Mello" and as a cross of the unpatented cultivar "Reiter 323" and a Canadian cultivar known as "Chilcotin" is disclosed. The cultivar exhibits minutely spiny primocanes with predominately ternately pinnate leaves, minutely prickled pedicels and bright glossy red berries.

Abstract: The invention concerns a new and distinct variety of hybrid raspberry, the variety being particularly characterized and distinguished its significant primocane production from Aug. 15 to Nov. 30 accounting for one third of the total yield; the floricane production occurs from about May 7 to July 30; the fruit is of medium to large size, firm, and has drupelets of uniform size and color. The torus is short and tapering without prominent spicules. Fruit is of excellent fresh market quality with only a slight tendency to darken after harvest. The new variety holds its distinguishing characteristics through succeeding propagations by planting dormant canes, dormant root cuttings and non-dormant root shoot cuttings.

Abstract: The invention concerns a new and distinct variety of hybrid raspberry, the variety being particularly characterized and distinguished by the early fruiting of both the primocane and floricane crops; the primocanes bearing approximately one half of the total of the combined primocane and floricane crops; the fruit has a bright red color with only a slight tendency to darken or develop a waxy bloom; the drupelets are of substantially uniform size and have only a slight median drupelet groove; the fruit is firm and compact with a ring of tight fitting drupelets at its collar; and even after relatively warm central California coastal winters the floricane budbreak is good. The new variety holds its distinguishing characteristics through succeeding propagations by planting dormant root cuttings, dormant canes and non-dormant root shoot cuttings.

Abstract: A new and distinct variety of red raspberry plant named `Isabel`, which is particularly characterized and distinguished by its consistently large size fruit of excellent flavor and color and its high yielding capacity on both primocane and floricane crops.

Abstract: A new and distinct cultivar of red raspberry plant named `Wilhelm`, which is particularly characterized and distinguished by its very attractive fruit and its high yielding capacity on both primocane and floricane crops.