Abstract: The systems, methods, and apparatuses provided herein disclose interpreting a performance criteria for a vehicle, wherein the performance criteria is indicative of a desired operating parameter for the vehicle; interpreting a good driver definition value indicative of a good driver profile for the interpreted performance criteria; determining a performance value indicative of how an operator of the vehicle is performing with respect to the good driver definition value; and in response to the performance value indicating that the vehicle is not satisfying the performance criteria, managing an actuator output response value for at least one actuator in the vehicle to facilitate achievement of the good driver definition value.

Abstract: A system and method of detecting fueling imbalance(s) in an internal combustion engine is provided. The method includes receiving data regarding an oxygen content of engine exhaust for the engine operating at a cycle rate. Frequency component analysis is performed comprising a filtering operation on the received oxygen content data. The filtering is done at the cycle rate of the engine or harmonics thereof to obtain filtered oxygen content data. Then, the method/system determines at least one of: 1) one or more angles of the engine at which the filtered oxygen content data exhibits a first amplitude value characteristic relative to amplitude values at other angles; and 2) a shape of the filtered oxygen content data obtained by sampling at pre-defined engine angles. The method/system then identifies a cylinder experiencing a fueling imbalance responsive to the determined at least one of one or more angle(s) and shape of the data.

Abstract: A method includes operating a spark ignition engine and flowing low pressure exhaust gas recirculation (EGR) from an exhaust to an inlet of the spark ignition engine. The method includes interpreting a parameter affecting an operation of the spark ignition engine, and determining a knock index value in response to the parameter. The method further includes reducing a likelihood of engine knock in response to the knock index value exceeding a knock threshold value.

Abstract: One exemplary embodiment is a system comprising a multi-fuel engine structured to selectably combust varying proportions of a first type of fuel and a second type of fuel, and an electronic control system structured to control the provision of at least one of the first type of fuel and the second type of fuel to the engine using a multi-factor cost optimization. The multi-factor cost optimization may account for a plurality of factors including one or more environment factors, location factors, mission factors, warranty factors, operator-specified factors and/or fleet-specified factors.

Abstract: An apparatus includes an initial planning module, a tandem implementation module, and a scheduler module. The initial planning module is structured to interpret one or more fleet delivery requirements, assets, drivers, and vehicle descriptions. The tandem implementation module is structured to determine a travel schedule with respect to a first vehicle and a second vehicle that enables the first vehicle and the second vehicle to travel in tandem for a least a portion of a route in response to input from the initial planning module. The scheduler module is structured to provide a fleet delivery schedule to the first vehicle and the second vehicle in response to the determination of the tandem implementation module.

Abstract: Provided herein are methods and compositions to effectively isolate nucleic acids using protein-based sample collection matrices.

Abstract: Systems and methods are disclosed for determining a recommended route reference for a vehicle based on simulations of a model of the vehicle including load information, route information, and a cost strategy, and providing commands to an output device based on the recommended route reference to provide an operator of the vehicle with feedback on the recommended route reference and/or to control the vehicle.

Abstract: An apparatus includes an initial planning module, a tandem implementation module, and a scheduler module. The initial planning module is structured to interpret one or more fleet delivery requirements, assets, drivers, and vehicle descriptions. The tandem implementation module is structured to determine a travel schedule with respect to a first vehicle and a second vehicle that enables the first vehicle and the second vehicle to travel in tandem for a least a portion of a route in response to input from the initial planning module. The scheduler module is structured to provide a fleet delivery schedule to the first vehicle and the second vehicle in response to the determination of the tandem implementation module.

Abstract: The systems, methods, and apparatuses provided herein disclose interpreting a performance criteria for a vehicle, wherein the performance criteria is indicative of a desired operating parameter for the vehicle; interpreting a good driver definition value indicative of a good driver profile for the interpreted performance criteria; determining a performance value indicative of how an operator of the vehicle is performing with respect to the good driver definition value; and in response to the performance value indicating that the vehicle is not satisfying the performance criteria, managing an actuator output response value for at least one actuator in the vehicle to facilitate achievement of the good driver definition value.

Abstract: One exemplary embodiment is a system comprising a multi-fuel engine structured to selectably combust varying proportions of a first type of fuel and a second type of fuel, and an electronic control system structured to control the provision of at least one of the first type of fuel and the second type of fuel to the engine using a multi-factor cost optimization. The multi-factor cost optimization may account for a plurality of factors including one or more environment factors, location factors, mission factors, warranty factors, operator-specified factors and/or fleet-specified factors.

Abstract: The present invention provides methods and reagents for the detection of a mutation in BRAF and methods of selecting patients for treatment if a B-Raf kinase inhibitor, such as a selective B-Raf kinase inhibitor.

Abstract: An apparatus includes a logistics manager that includes a processor. The logistics manager is communicably coupled to at least one of a first wireless communication module onboard a first vehicle and a second wireless communication module onboard a second vehicle. The logistics manager is configured to: receive, via the first wireless communication module, first data regarding the first vehicle, where the first data is provided by a first sensor module onboard the first vehicle; receive, via the second wireless communication module, second data regarding the second vehicle, where the second data is provided by a second sensor module onboard the second vehicle; and provide navigational commands to at least one of the first vehicle and the second vehicle based on a cost and benefit analysis in response to at least one the first data and the second data.

Abstract: Various embodiments disclosed herein relate to the access, management, and targeted display of one or more asset display profiles to a person of interest (e.g., an associated asset creator, a customer, etc.). A method includes interpreting an asset display profile corresponding to a creative asset description and an associated asset creator; determining an asset display context; and in response to the asset display profile and the asset display context, providing an asset display description to an output device.

Abstract: A multi-layer plasma separation card comprising (a) a first layer including a sample receiving member comprising (i) a top planar surface for applying or receiving a blood sample, said sample receiving portion being adapted to permit contact of said blood sample with a separating member; and (ii) a bottom planar surface being adapted to contact said separating member, (b) a second layer including at least three separating members, each separating member being adapted to permit the passage of plasma to an absorptive member and comprising (i) a top planar surface for receiving said blood sample; and (ii) a bottom planar shield-sharped surface being adapted to contact said absorptive member, and (c) a third layer including at least two absorptive members for absorbing plasma from the bottom planar surface of each corresponding separating member and a backing member arranged in a manner to support said absorptive members, each absorptive member comprising a removable absorptive element having a top planar surface

Abstract: The present invention provides a method for the amplification of at least a first and a second target nucleic acid that may be present in a fluid sample. The invention further provides a kit and an analytical system for carrying out said amplification.

Abstract: The present invention provides reagents for use in the amplification of nucleic acids. Amplification carried out using oligonucleotides containing modified nucleotides can result in less non-specific amplification compared to amplification carried out using unmodified oligonucleotides.

Abstract: There is disclosed a method for treating Equine Metabolic Syndrome (EMS) comprising administering an acetyl cholinesterase inhibitor compound to the suspected EMS horse. The present disclosure further provides a method for treating feline or canine diabetes and feline or canine renal disease comprising administering an acetyl cholinesterase inhibitor compound to the suspected feline or canine.

Abstract: The present invention concerns the amplification of at least a first and a second target nucleic acid that may be present in at least one fluid sample using an internal control nucleic acid for qualitative and/or quantitative purposes.

Abstract: Systems and methods are disclosed for determining a recommended route reference for a vehicle based on simulations of a model of the vehicle including load information, route information, and a cost strategy, and providing commands to an output device based on the recommended route reference to provide an operator of the vehicle with feedback on the recommended route reference and/or to control the vehicle.

Abstract: An apparatus includes a logistics manager that includes a processor. The logistics manager is communicably coupled to at least one of a first wireless communication module onboard a first vehicle and a second wireless communication module onboard a second vehicle. The logistics manager is configured to: receive, via the first wireless communication module, first data regarding the first vehicle, where the first data is provided by a first sensor module onboard the first vehicle; receive, via the second wireless communication module, second data regarding the second vehicle, where the second data is provided by a second sensor module onboard the second vehicle; and provide navigational commands to at least one of the first vehicle and the second vehicle based on a cost and benefit analysis in response to at least one the first data and the second data.