Abstract: An isolated or purified antisense oligomer for modifying pre-mRNA splicing in the Angiotensin Converting Enzyme 2 (ACE2) to modulate splicing of the ACE2 gene transcript or part thereof which has a modified backbone structure and sequences with at least 75% sequence identity to such antisense oligomers and which have a modified backbone structure.

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

Abstract: An isolated or purified antisense oligomer with a modified backbone structure for modifying pre-mRNA splicing in the parkin gene transcript or part thereof.

Abstract: Embodiments in accordance with the present disclosure include a meta-stable detergent based foam generating device of a turbine cleaning system includes a manifold configured to receive a liquid detergent and an expansion gas, a gas supply source configured to store the expansion gas, and one or more aerators fluidly coupled with, and between, the gas supply source and the manifold. Each aerator of the one or more aerators comprises an orifice through which the expansion gas enters the manifold, and wherein the orifice of each aerator is sized to enable generation of a meta-stable detergent based foam having bubbles with bubble diameters within a range of 10 microns (3.9×10?4 inches inches) and 5 millimeters (0.2 inches), having a half-life within a range of 5 minutes and 180 minutes, or a combination thereof.

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

Abstract: Embodiments in accordance with the present disclosure include a meta-stable detergent based foam generating device of a turbine cleaning system includes a manifold configured to receive a liquid detergent and an expansion gas, a gas supply source configured to store the expansion gas, and one or more aerators fluidly coupled with, and between, the gas supply source and the manifold. Each aerator of the one or more aerators comprises an orifice through which the expansion gas enters the manifold, and wherein the orifice of each aerator is sized to enable generation of a meta-stable detergent based foam having bubbles with bubble diameters within a range of 10 microns (3.9×10?4 inches) and 5 millimeters (0.2 inches), having a half-life within a range of 5 minutes and 180 minutes, or a combination thereof.

Abstract: The present invention relates to the delivery of oligomers for treating patients with a 5? mutation in their DMD gene other than a DMD exon 2 duplication. The invention provides methods and materials for activating an internal ribosome entry site in exon 5 of the DMD gene resulting in translation of a functional truncated isoform of dystrophin. The methods and materials can be used for the treatment of muscular dystrophies arising from 5? mutations in the DMD gene such as Duchenne Muscular Dystrophy or Becker Muscular Dystrophy.

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

Abstract: The present invention relates to the delivery of oligomers for treating patients with a 5? mutation in their DMD gene other than a DMD exon 2 duplication. The invention provides methods and materials for activating an internal ribosome entry site in exon 5 of the DMD gene resulting in translation of a functional truncated isoform of dystrophin. The methods and materials can be used for the treatment of muscular dystrophies arising from 5? mutations in the DMD gene such as Duchenne Muscular Dystrophy or Becker Muscular Dystrophy.

Abstract: Embodiments in accordance with the present disclosure include a meta-stable detergent based foam generating device of a turbine cleaning system includes a manifold configured to receive a liquid detergent and an expansion gas, a gas supply source configured to store the expansion gas, and one or more aerators fluidly coupled with, and between, the gas supply source and the manifold. Each aerator of the one or more aerators comprises an orifice through which the expansion gas enters the manifold, and wherein the orifice of each aerator is sized to enable generation of a meta-stable detergent based foam having bubbles with bubble diameters within a range of 10 microns (3.9×10?4 inches inches) and 5 millimeters (0.2 inches), having a half-life within a range of 5 minutes and 180 minutes, or a combination thereof.

Abstract: Embodiments in accordance with the present disclosure include a meta-stable detergent based foam generating device of a turbine cleaning system includes a manifold configured to receive a liquid detergent and an expansion gas, a gas supply source configured to store the expansion gas, and one or more aerators fluidly coupled with, and between, the gas supply source and the manifold. Each aerator of the one or more aerators comprises an orifice through which the expansion gas enters the manifold, and wherein the orifice of each aerator is sized to enable generation of a meta-stable detergent based foam having bubbles with bubble diameters within a range of 10 microns (3.9×10?4 inches) and 5 millimeters (0.2 inches), having a half-life within a range of 5 minutes and 180 minutes, or a combination thereof.

Abstract: The invention teaches antisense agents and RNA interference agents useful for treating diseases and conditions the treatment of which can benefit from reducing the expression of double homeobox 4 and/or double homeobox 4c, more particularly facioscapulohumeral muscular dystrophy. Further elaborated are methods, uses and further products employing such agents.

Abstract: An apparatus for scavenging lubricating oil comprises an integrated slinger/runner rotatable with the turbine engine rotor discourages oil seepage out of an oil sump of a forward bearing for a gas turbine engine during all operating conditions of the gas turbine engine from idle to take-off speeds and during static non-operation. The apparatus includes a runner comprising an axially forward section and a frusto-conical aft section, and a slinger joined coaxially integrally to the aft frusto-conical aft section. The apparatus includes a means for blocking flow of oil from the frusto-conical aft section toward the axially forward section.

Abstract: A device and method for uniformly providing lubricant to rotating machine parts is provided. The device comprises an axially mounted rotating circumferential lubricant reservoir with a weir comprising one side of the lubricant reservoir. The reservoir and weir are disposed at uniform radius and circumferentially about an axis of rotation causing lubricant added to the reservoir to flow uniformly over the weir about the circumference of the weir when the device is in high speed rotational motion. Because of the uniform flow of lubricant over the top of the weir around the circumference of the weir, lubricant can be directed to machine parts requiring lubrication in a uniform manner around the circumference of the moving device.

Abstract: A semiconductor component is suitable for limiting transient voltages on the supply lines of a system having at least three supply lines, one of the supply lines being a current sink. The semiconductor comprises: at least three input means for connection to respective ones of the supply lines; and for each input means, a respective overvoltage-triggered semiconductor protection unit. Each protection unit comprises a multi-junction diode which has a threshold voltage at which it changes from a high-impedance state to a low-impedance state and a respective further diode connected in shunt with it and in the opposite sense to it. Each multi-junction diode is connected in the same sense between a respective input means and a common terminal; and each protection unit is adapted to use a lateral turn on current. A shielding diffusion is provided between adjacent protection units for blocking lateral current flow between the adjacent protection units.

Abstract: A body of semiconductor material for use in forming a low voltage surface breakdown protection device comprises a substrate having upper and lower surfaces, and a PN junction formed between first (16) and second (14) regions of the body in which in the intended operation of the device reverse breakdown of the junction occurs. The substrate forms the first region (16) which is of lower impurity concentration than the second region (14) and the second (14) region extends to the upper surface of the substrate (16). First and second edge breakdown regions (42, 44) extending to the upper surface of the substrate are provided in the first region (16). They are of the same conductivity type as and of higher impurity concentration than the first region (16).

Abstract: A PNPN semiconductor switching device for igniter circuits comprises first and third diffusion layers of N-type conductivity semiconductor material, second and fourth diffusion layers of P-type conductivity type semiconductor material, and a first buried region of N-type conductivity in the third layer adjacent to the junction between the second and third layers. The buried region has a greater impurity concentration than the third layer and serves to control the switching voltage of the device The first to third diffusion layers form an NPN transistor and a resistance is formed as part of the transistor base diffusion between the base and emitter diffusion regions of the transistor for controlling the switching current of the device.