Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

Abstract: The present invention relates to the field of antisense oligonucleotides used to reduce expression of selected alleles of the FUS gene which encodes the protein FUS or variants thereof. The invention also provides pharmaceutical compositions and methods to treat the effects of a disease associated with pathogenic FUS genetic variants by administration of antisense oligonucleotides and therapeutic compositions comprising AONs targeted to FUS or variants thereof.

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

Abstract: An isolated or purified antisense oligomer for modifying pre-mRNA splicing in the Angiotensin Converting Enzyme 2 (ACE2) to modulate splicing of the ACE2 gene transcript or part thereof which has a modified backbone structure and sequences with at least 75% sequence identity to such antisense oligomers and which have a modified backbone structure.

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

Abstract: An isolated or purified antisense oligomer with a modified backbone structure for modifying pre-mRNA splicing in the parkin gene transcript or part thereof.

Abstract: Embodiments in accordance with the present disclosure include a meta-stable detergent based foam generating device of a turbine cleaning system includes a manifold configured to receive a liquid detergent and an expansion gas, a gas supply source configured to store the expansion gas, and one or more aerators fluidly coupled with, and between, the gas supply source and the manifold. Each aerator of the one or more aerators comprises an orifice through which the expansion gas enters the manifold, and wherein the orifice of each aerator is sized to enable generation of a meta-stable detergent based foam having bubbles with bubble diameters within a range of 10 microns (3.9×10?4 inches inches) and 5 millimeters (0.2 inches), having a half-life within a range of 5 minutes and 180 minutes, or a combination thereof.

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

Abstract: Embodiments in accordance with the present disclosure include a meta-stable detergent based foam generating device of a turbine cleaning system includes a manifold configured to receive a liquid detergent and an expansion gas, a gas supply source configured to store the expansion gas, and one or more aerators fluidly coupled with, and between, the gas supply source and the manifold. Each aerator of the one or more aerators comprises an orifice through which the expansion gas enters the manifold, and wherein the orifice of each aerator is sized to enable generation of a meta-stable detergent based foam having bubbles with bubble diameters within a range of 10 microns (3.9×10?4 inches) and 5 millimeters (0.2 inches), having a half-life within a range of 5 minutes and 180 minutes, or a combination thereof.

Abstract: The present invention relates to the delivery of oligomers for treating patients with a 5? mutation in their DMD gene other than a DMD exon 2 duplication. The invention provides methods and materials for activating an internal ribosome entry site in exon 5 of the DMD gene resulting in translation of a functional truncated isoform of dystrophin. The methods and materials can be used for the treatment of muscular dystrophies arising from 5? mutations in the DMD gene such as Duchenne Muscular Dystrophy or Becker Muscular Dystrophy.

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

Abstract: The present invention relates to the delivery of oligomers for treating patients with a 5? mutation in their DMD gene other than a DMD exon 2 duplication. The invention provides methods and materials for activating an internal ribosome entry site in exon 5 of the DMD gene resulting in translation of a functional truncated isoform of dystrophin. The methods and materials can be used for the treatment of muscular dystrophies arising from 5? mutations in the DMD gene such as Duchenne Muscular Dystrophy or Becker Muscular Dystrophy.

Abstract: Embodiments in accordance with the present disclosure include a meta-stable detergent based foam generating device of a turbine cleaning system includes a manifold configured to receive a liquid detergent and an expansion gas, a gas supply source configured to store the expansion gas, and one or more aerators fluidly coupled with, and between, the gas supply source and the manifold. Each aerator of the one or more aerators comprises an orifice through which the expansion gas enters the manifold, and wherein the orifice of each aerator is sized to enable generation of a meta-stable detergent based foam having bubbles with bubble diameters within a range of 10 microns (3.9×10?4 inches inches) and 5 millimeters (0.2 inches), having a half-life within a range of 5 minutes and 180 minutes, or a combination thereof.

Abstract: Embodiments in accordance with the present disclosure include a meta-stable detergent based foam generating device of a turbine cleaning system includes a manifold configured to receive a liquid detergent and an expansion gas, a gas supply source configured to store the expansion gas, and one or more aerators fluidly coupled with, and between, the gas supply source and the manifold. Each aerator of the one or more aerators comprises an orifice through which the expansion gas enters the manifold, and wherein the orifice of each aerator is sized to enable generation of a meta-stable detergent based foam having bubbles with bubble diameters within a range of 10 microns (3.9×10?4 inches) and 5 millimeters (0.2 inches), having a half-life within a range of 5 minutes and 180 minutes, or a combination thereof.

Abstract: An apparatus for scavenging lubricating oil comprises an integrated slinger/runner rotatable with the turbine engine rotor discourages oil seepage out of an oil sump of a forward bearing for a gas turbine engine during all operating conditions of the gas turbine engine from idle to take-off speeds and during static non-operation. The apparatus includes a runner comprising an axially forward section and a frusto-conical aft section, and a slinger joined coaxially integrally to the aft frusto-conical aft section. The apparatus includes a means for blocking flow of oil from the frusto-conical aft section toward the axially forward section.

Abstract: A device and method for uniformly providing lubricant to rotating machine parts is provided. The device comprises an axially mounted rotating circumferential lubricant reservoir with a weir comprising one side of the lubricant reservoir. The reservoir and weir are disposed at uniform radius and circumferentially about an axis of rotation causing lubricant added to the reservoir to flow uniformly over the weir about the circumference of the weir when the device is in high speed rotational motion. Because of the uniform flow of lubricant over the top of the weir around the circumference of the weir, lubricant can be directed to machine parts requiring lubrication in a uniform manner around the circumference of the moving device.