Patents by Inventor Stephen Y. Chou

Stephen Y. Chou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220136969
    Abstract: Among other things, the disclosure of the present invention is related to make pathology and cytology faster, better and lower cost. The present invention also related to rapid intracellular assay.
    Type: Application
    Filed: April 28, 2020
    Publication date: May 5, 2022
    Applicant: Essenlix Corporation
    Inventors: Stephen Y. CHOU, Wei DING, Yu Sun
  • Publication number: 20220137038
    Abstract: The present invention provides devices, systems, and methods, for performing biological and chemical assays.
    Type: Application
    Filed: February 6, 2020
    Publication date: May 5, 2022
    Applicant: Essenlix Corporation
    Inventors: Stephen Y. Chou, Wei Ding
  • Publication number: 20220120740
    Abstract: The present invention provides devices, systems, and methods, for performing biological and chemical assays.
    Type: Application
    Filed: December 15, 2021
    Publication date: April 21, 2022
    Applicant: Essenlix Corporation
    Inventors: Stephen Y. Chou, Wei Ding, Ji Li, Yufan Zhang
  • Publication number: 20220113292
    Abstract: Systems and methods for monitoring the health status of a subject are provided. In certain embodiments, the method includes: applying a sample provided from a subject to a signal enhancing detector configured to indicate an output that is representative of the sample; processing the output with a device configured to acquire the detector output as input data and process the input data to generate a report; and receiving the report. In certain embodiments, the device is a mobile device. In certain embodiments, the method further includes transmitting the sample-derived data in the device to a remote location where the transmitted data is analyzed; and receiving the results of the analysis. Also provided are systems for use in practicing the methods. Kits for use in monitoring the health status of a subject are also provided.
    Type: Application
    Filed: April 16, 2021
    Publication date: April 14, 2022
    Inventor: Stephen Y. Chou
  • Publication number: 20220091092
    Abstract: Disclosed is a method for correlating a biomarker in a non-blood bodily fluid with the same biomarker in the blood of an individual, including: measuring, in a first period in time, the biomarker in non-blood bodily fluid and measuring the same biomarker in the blood of the same individual to establish an R ratio of [NBBF1]/[BB1], where [NBBF1] is the biomarker concentration in non-blood bodily fluid in the first period in time, and [BB1] is the biomarker concentration in the blood in the first period in time; storing the ratio in a memory; measuring, in a second period in time, the biomarker in non-blood bodily fluid to determine [NBBF2], where [NBBF2] is the biomarker concentration in the non-blood bodily fluid in the second period in time; and correlating the measured [NBBF2] with the R ratio to generate a correlated [BB2] biomarker concentration in the blood of the individual in the second period in time.
    Type: Application
    Filed: November 6, 2020
    Publication date: March 24, 2022
    Applicant: Essenlix Corporation
    Inventors: Stephen Y. CHOU, Wei DING
  • Patent number: 11280706
    Abstract: The present disclosure provides devices, systems, and methods, for performing biological and chemical assays.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: March 22, 2022
    Assignee: Essenlix Corporation
    Inventors: Stephen Y. Chou, Wei Ding
  • Patent number: 11274996
    Abstract: The present invention relates to the methods, devices, and systems that make bio/chemical sensing (including, not limited to, immunoassay, nucleic assay, electrolyte analysis, etc.) faster, more sensitive, less steps, easy to perform, smaller amount of samples required, less or reduced (or no) needs for professional assistance, and/or lower cost, than many current sensing methods and devices. The present invention also allow a test performed by a smartphone.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: March 15, 2022
    Assignee: Essenlix Corporation
    Inventors: Stephen Y. Chou, Wei Ding, Ji Qi, Yufan Zhang
  • Publication number: 20220072557
    Abstract: A device for sample analysis, including: a first plate, a second plate, spacers, a hinge, and an adhesive, wherein the first plate and the second plate are connected by the hinge and movable relative to each other around the axis of the hinge into different configurations, including an open configuration and a closed configuration as disclosed herein. Also disclosed are a kit, a system, and a method including the device.
    Type: Application
    Filed: February 14, 2020
    Publication date: March 10, 2022
    Applicant: Essenlix Corporation
    Inventors: Stephen Y. CHOU, Wei DING, Ji QI
  • Publication number: 20220044074
    Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of image-based assay, that uses imaging system having uncertainties or deviations (imperfection) compared with an ideal imaging system. One aspect of the present invention is to add the monitoring marks on the sample holder, with at least one of their geometric and/optical properties of the monitoring marks under predetermined and known, and taking images of the sample with the monitoring marks, and train a machine learning model using the images with the monitoring mark.
    Type: Application
    Filed: November 25, 2020
    Publication date: February 10, 2022
    Applicant: Essenlix Corporation
    Inventors: Xing Li, Wu CHOU, Stephen Y. CHOU, Wei DING
  • Publication number: 20220042910
    Abstract: A multi-mode illumination system, including: a first illumination module; a second illumination module; and a third illumination module, as disclosed herein.
    Type: Application
    Filed: February 14, 2020
    Publication date: February 10, 2022
    Applicant: Essenlix Corporation
    Inventors: Ji Qi, Stephen Y. Chou, Wei Ding
  • Publication number: 20220043249
    Abstract: A device, including: an end-emitting optical fiber including a first end and a second end; a light extraction plate including a light scattering structure; and a light diffuser film disposed above the light scattering structure. Also disclosed are systems including the device.
    Type: Application
    Filed: February 14, 2020
    Publication date: February 10, 2022
    Applicant: Essenlix Corporation
    Inventors: Ji Qi, Stephen Y. Chou, Wei Ding
  • Patent number: 11243201
    Abstract: The present invention provides devices, systems, and methods, for performing biological and chemical assays.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: February 8, 2022
    Assignee: Essenlix Corporation
    Inventors: Stephen Y. Chou, Wei Ding, Ji Li, Yufan Zhang
  • Patent number: 11237113
    Abstract: Among other things, certain embodiments of the present disclosure are related to devices and methods of performing biological and chemical assays, such as but not limited to pH measurement of bio/chemical samples.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: February 1, 2022
    Assignee: Essenlix Corporation
    Inventors: Stephen Y. Chou, Wei Ding, Yuecheng Zhang
  • Publication number: 20210392244
    Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of an image-based assay. One aspect of the present invention is to sandwich a sample between two plates and add reference marks in the sample areas of the plates, with at least one of the geometric and/optical properties of the reference marks being predetermined and known, and taking images of the sample with the reference marks, and applying a machine learning model in the analysis of the image-based assay.
    Type: Application
    Filed: February 18, 2021
    Publication date: December 16, 2021
    Applicant: Essenlix Corporation
    Inventors: Stephen Y. Chou, Wei Ding, Yufan Zhang, Ji Qi, Jun Tian, Wei Dong
  • Publication number: 20210293838
    Abstract: Provided herein is a method of analyzing a biological sample collected from a subject. An implementation of the method may include a) receiving, at a first site, data transmitted from a data acquisition device at a second site, wherein the data acquisition device is configured to i) read an output signal that is representative of the biological sample from a disk-coupled dots-on-pillar antenna array (D2PA) device comprising a D2PA to generate raw data that is representative of the biological sample, and ii) transmit data comprising the raw data to the first site, and b) analyzing the data at the first site to generate an evaluation of the data. In some embodiments, the method includes providing a process management operation such that the evaluation can be used for screening, diagnosis, or treatment of the subject. Also provided herein are systems that find use in implementing the method.
    Type: Application
    Filed: October 22, 2020
    Publication date: September 23, 2021
    Inventor: Stephen Y. Chou
  • Patent number: 11105791
    Abstract: The present invention provides methods and apparatus that can manipulate, detect, and/or analyze single molecules, single small particles or single small samples of matter passing through a nanoscale gap within a nanofluidic channel of a detector.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: August 31, 2021
    Inventors: Stephen Y. Chou, Xiaogan Liang
  • Publication number: 20210262920
    Abstract: Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between containing between two plates.
    Type: Application
    Filed: February 12, 2021
    Publication date: August 26, 2021
    Applicant: Essenlix Corporation
    Inventors: Stephen Y. CHOU, Wei DING, Ji QI, Jun Tian, Wu Chou
  • Patent number: 11029529
    Abstract: The present inventions is related to the optical lenses that use subwavelength structures to perform an optical function, the applications of such lenses, and the methods of making the same. Particularly, the present invention provide an optical lens(es), termed “subwavelength Moiré index lens” or “SMIL” for manipulating light. The SMIL comprises a thin material layer having an effective optical index that has a Moiré pattern of two or more periodic structures. The SMIL allows a lens to be ultrathin, flat, numerical aperture nearly one, scalable to large area, and manufacturable at low cost. The present invention also provides the systems based on SMIL, such lens systems, LEDs and photodetectors, and the fabrication methods of the SMIL.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: June 8, 2021
    Inventors: Stephen Y. Chou, Fei Ding, Wei Ding
  • Publication number: 20210156771
    Abstract: The present invention is related to the field of bio/chemical sampling, sensing, assays and applications. Particularly, the present invention is related to how to make the sampling/sensing/assay become simple to use, fast to results, highly sensitive, easy to use, using tiny sample volume (e.g. 0.5 uL or less), operated by a person without any professionals, reading by mobile-phone, or low cost, or a combination of them.
    Type: Application
    Filed: January 28, 2021
    Publication date: May 27, 2021
    Applicant: Essenlix Corporation
    Inventors: Stephen Y. CHOU, Wei DING
  • Publication number: 20210138474
    Abstract: The present invention provides devices, systems, and methods for rapid and easy-to-use in sample thermal cycling or temperature changes for the facilitation of reactions such as but not limited to PCR.
    Type: Application
    Filed: January 15, 2021
    Publication date: May 13, 2021
    Applicant: Essenlix Corporation
    Inventors: Stephen Y. Chou, Wei Ding, Yufan Zhang, Hua Tan