Abstract: Provided are therapeutic combinations, pharmaceutical compositions, and pharmaceutical kits comprising fungi (e.g., Psilocybe spp. fungi), plants (e.g., Cannabis spp., Dipteryx spp.), and algae (e.g., from the family Bangicaeae, including Pyropia spp. and Porphyra spp.), including extracts and bioactive molecules derived therefrom. Methods of producing the disclosed combinations, compositions, and kits are also provided, such as using natural, biosynthetic, or synthetic means. Further provided are methods of using the disclosed combinations, compositions, and kits in the treatment of medical conditions, and in particular for treating inflammatory diseases and conditions, for which the disclosed combinations are demonstrated to provide significant advantages.