Abstract: A method of improving data sets, for example, of patients, each being characterized by relatively low-cost medical data, identifies those patients where the acquisition of higher cost medical data would best inform an estimate of the higher cost medical data for the remaining patients. In this way scarce medical resources can be more efficiently applied in characterizing a potential patient pool, for example, for a clinical trial when resources are not available for extensive medical characterization of each trial participant.

Abstract: A method of improving data sets, for example, of patients, each being characterized by relatively low-cost medical data, identifies those patients where the acquisition of higher cost medical data would best inform an estimate of the higher cost medical data for the remaining patients. In this way scarce medical resources can be more efficiently applied in characterizing a potential patient pool, for example, for a clinical trial when resources are not available for extensive medical characterization of each trial participant.

Abstract: A tack for intraocular drug delivery and a method for insertion and removal of an intraocular device for sustained release of a drug are provided. The tack comprises a post, an anchoring region and a head. The post is for being positioned within the vitreous region of the eye. The post has a first end and a second end, and includes a drug to be administered. The anchoring region is affixed to the second end of the post, and includes a width measured perpendicularly to a longitudinal axis of the tack which varies to provide the anchoring region with a configuration to anchor the tack within at least one of a sclera, a retina and a choroid. The head extends radially outwardly from the anchoring region such that upon insertion of the anchoring region and post within the eye, the head remains external to the eye and abuts a scleral surface of the eye. Other embodiments include a tack comprising a post, a central portion, a head and a suture hole through the head for anchoring the head to the sclera.