Patents by Inventor Stevan Bajic
Stevan Bajic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11733247Abstract: A method of ionising a sample is disclosed comprising nebulising a sample which includes first biomolecules such as bovine insulin comprising one or more disulphide (S—S) bonds. A stream of droplet or charged droplets comprising one or more disulphide (S—S) bonds is directed so as to impact upon a target (106) or electrode so as to cause the breaking of a portion of the disulphide bonds. Alternatively, charged droplets may pass through an electric field region determined by an electrode (106) arranged downstream of a nebuliser or electrospray probe and an ion inlet (104) of a mass spectrometer so as to cause the breaking of a portion of the disulphide bonds.Type: GrantFiled: April 13, 2018Date of Patent: August 22, 2023Assignee: Micromass UK LimitedInventors: Stevan Bajic, Jeffery Mark Brown
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Patent number: 11705318Abstract: An impact ionisation spray or electrospray ionisation ion source comprising a nebuliser (30) having a first conduit (11) for providing a liquid sample and a second conduit (10) for providing a nebulisation gas in order to nebulise the liquid sample is disclosed. The first conduit (11) and second conduit (10) are of unitary construction with each other and may be made from glass. The ion source can provide a consistent and/or predictable spray profile for the nebulised sample.Type: GrantFiled: May 15, 2019Date of Patent: July 18, 2023Assignee: Micromass UK LimitedInventor: Stevan Bajic
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Patent number: 11699583Abstract: An ion source is provided comprising a nebuliser or electrospray probe (1) for nebulising a sample and an impact surface or target electrode (5). The impact surface or target electrode (5) comprises a tarnishable or oxidisable metal or an alloy comprising a tarnishable or oxidisable metal. Also provided is an ion source comprising a nebuliser or electrospray probe with a central wire comprising a tarnishable or oxidisable metal or an alloy comprising a tarnishable or oxidisable metal or an alloy comprising a tarnishable or oxidisable metal. Adducts with relatively heavy metals result in simplified multiply-charged mass spectra that are easier to interpret.Type: GrantFiled: July 4, 2019Date of Patent: July 11, 2023Assignee: Micromass UK LimitedInventors: Stevan Bajic, Jeffery Mark Brown
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Patent number: 11387091Abstract: A method of ionisation is disclosed in which a sample is heated such that analyte is released from the sample. Analyte released from the sample is accumulated, and then the accumulated analyte is passed to an ionisation region where the analyte is ionised.Type: GrantFiled: June 20, 2019Date of Patent: July 12, 2022Assignee: Micromass UK LimitedInventors: Stevan Bajic, David Douce, Scott Pritchard
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Patent number: 11282691Abstract: A method of ionizing a sample is disclosed that comprises heating a sample so that analyte is released from the sample, producing charged particles such as charged droplets downstream of the sample, and using the charged particles to ionize at least some of the analyte released from the sample so as to produce analyte ions.Type: GrantFiled: December 21, 2018Date of Patent: March 22, 2022Assignee: Micromass UK LimitedInventors: Stevan Bajic, David S. Douce
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Publication number: 20210285956Abstract: A method of ionising a sample is disclosed comprising nebulising a sample which includes first biomolecules such as bovine insulin comprising one or more disulphide (S—S) bonds. A stream of droplet or charged droplets comprising one or more disulphide (S—S) bonds is directed so as to impact upon a target (106) or electrode so as to cause the breaking of a portion of the disulphide bonds. Alternatively, charged droplets may pass through an electric field region determined by an electrode (106) arranged downstream of a nebuliser or electrospray probe and an ion inlet (104) of a mass spectrometer so as to cause the breaking of a portion of the disulphide bonds.Type: ApplicationFiled: April 13, 2018Publication date: September 16, 2021Inventors: Stevan Bajic, Jeffery Mark Brown
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Publication number: 20210280408Abstract: An ion source is provided comprising a nebuliser or electrospray probe (1) for nebulising a sample and an impact surface or target electrode (5). The impact surface or target electrode (5) comprises a tarnishable or oxidisable metal or an alloy comprising tarnishable or oxidisable metal. Also provided is an ion source comprising a nebuliser or electrospray probe with a central wire comprising a tarnishable or oxidisable metal or an alloy comprising a tarnishable or oxidisable metal or an alloy comprising a tarnishable or oxidisable metal. Adducts with relatively heavy metals result in simplified multiply-charged mass spectra that are easier to interpret.Type: ApplicationFiled: July 4, 2019Publication date: September 9, 2021Applicant: Micromass UK LimitedInventors: Stevan Bajic, Jeffery Mark Brown
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Publication number: 20210210320Abstract: An impact ionisation spray or electrospray ionisation ion source comprising a nebuliser (30) having a first conduit (11) for providing a liquid sample and a second conduit (10) for providing a nebulisation gas in order to nebulise the liquid sample is disclosed. The first conduit (11) and second conduit (10) are of unitary construction with each other and may be made from glass. The ion source can provide a consistent and/or predictable spray profile for the nebulised sample.Type: ApplicationFiled: May 15, 2019Publication date: July 8, 2021Applicant: Micromass UK LimitedInventor: Stevan Bajic
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Publication number: 20210166929Abstract: A method of ionisation is disclosed in which a sample is heated such that analyte is released from the sample. Analyte released from the sample is accumulated, and then the accumulated analyte is passed to an ionisation region where the analyte is ionised.Type: ApplicationFiled: June 20, 2019Publication date: June 3, 2021Applicant: Micromass UK LimitedInventors: Stevan Bajic, David Douce, Scott Pritchard
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Publication number: 20210066059Abstract: A method of ionizing a sample is disclosed that comprises heating a sample so that analyte is released from the sample, producing charged particles such as charged droplets downstream of the sample, and using the charged particles to ionize at least some of the analyte released from the sample so as to produce analyte ions.Type: ApplicationFiled: December 21, 2018Publication date: March 4, 2021Inventors: Stevan Bajic, David S. Douce
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Patent number: 10859544Abstract: A secondary ultrasonic nebulisation device is disclosed comprising: a liquid sample delivery capillary; a sample receiving surface arranged for receiving a liquid sample from the capillary; and an ultrasonic transducer configured for oscillating the surface so as to nebulise the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample.Type: GrantFiled: September 24, 2019Date of Patent: December 8, 2020Assignee: Micromass UK LimiteInventors: Stevan Bajic, David S. Douce, Gordon A. Jones
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Patent number: 10679840Abstract: A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone 6 having an inlet aperture, wherein the gas cone 6 has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube 2 having an outlet and having a second longitudinal axis and a second capillary tube 3 which surrounds the first capillary tube 2. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube 2 so that the liquid exits the outlet of the first capillary tube 2 at a flow rate >200 ?L/min.Type: GrantFiled: January 24, 2019Date of Patent: June 9, 2020Assignee: Micromass UK LImitedInventors: Stevan Bajic, David Gordon, Daniel James Kenny, Richard Barrington Moulds, Stephen O'Brien, Ian Trivett, Kate Whyatt
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Publication number: 20200018733Abstract: A secondary ultrasonic nebulisation device is disclosed comprising: a liquid sample delivery capillary; a sample receiving surface arranged for receiving a liquid sample from the capillary; and an ultrasonic transducer configured for oscillating the surface so as to nebulise the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample.Type: ApplicationFiled: September 24, 2019Publication date: January 16, 2020Applicant: Micromass UK LimitedInventors: Stevan Bajic, David S. Douce, Gordon A. Jones
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Patent number: 10466213Abstract: A secondary ultrasonic nebulization device is disclosed comprising: a liquid sample delivery capillary; a sample receiving surface arranged for receiving a liquid sample from the capillary; and an ultrasonic transducer configured for oscillating the surface so as to nebulize the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample.Type: GrantFiled: December 21, 2016Date of Patent: November 5, 2019Assignee: MICROMASS UK LIMITEDInventors: Stevan Bajic, David S Douce, Gordon A Jones
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Publication number: 20190244800Abstract: A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone 6 having an inlet aperture, wherein the gas cone 6 has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube 2 having an outlet and having a second longitudinal axis and a second capillary tube 3 which surrounds the first capillary tube 2. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube 2 so that the liquid exits the outlet of the first capillary tube 2 at a flow rate >200 ?L/min.Type: ApplicationFiled: January 24, 2019Publication date: August 8, 2019Applicant: Micromass UK LimitedInventors: Stevan Bajic, David Gordon, Daniel James Kenny, Richard Barrington Moulds, Stephen O'Brien, Ian Trivett, Kate Whyatt
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Patent number: 10262851Abstract: There is provided an ion source comprising one or more nebulizers and one or more targets, wherein said one or more nebulizers are arranged and adapted to emit, in use, a stream predominantly of droplets which are caused to impact upon said one or more targets and to ionize said droplets to form a plurality of ions, wherein said one or more targets further comprise one or more structures configured to disturb gas flowing along a surface of said one or more targets.Type: GrantFiled: August 18, 2015Date of Patent: April 16, 2019Assignee: MICROMASS UK LIMITEDInventor: Stevan Bajic
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Patent number: 10236171Abstract: A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein the gas cone has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds the first capillary tube. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube so that the liquid exits the outlet of the first capillary tube at a flow rate >200 ?L/min.Type: GrantFiled: September 17, 2014Date of Patent: March 19, 2019Assignee: MICROMASS UK LIMITEDInventors: Stevan Bajic, David Gordon, Daniel James Kenny, Richard Barrington Moulds, Stephen O'Brien, Ian Trivett, Kate Whyatt
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Patent number: 10217622Abstract: An ion source is disclosed comprising a nebulizer 1 arranged and adapted to emit a liquid spray, a first target 5 arranged downstream of the nebulizer 1, wherein the liquid spray is arranged to impact upon the first target 5, and a sample target 10 arranged downstream of the first target 5, wherein a sample to be analyzed is provided at the sample target 10.Type: GrantFiled: December 27, 2017Date of Patent: February 26, 2019Assignee: MICROMASS UK LIMITEDInventor: Stevan Bajic
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Patent number: 10032612Abstract: A method of ion mapping is disclosed comprising depositing a sample onto a target surface and separating the sample on the target surface according to a first physico-chemical property in a first dimension and according to a second physico-chemical property in a second dimension. The method further comprises ionising and mass analysing multiple separate regions of the sample so as to generate an ion map of at least a portion of the sample deposited upon the target surface. The sample is deposited onto and separated on the target surface by mechanical, hydrodynamic and/or aerodynamic means.Type: GrantFiled: March 27, 2017Date of Patent: July 24, 2018Assignee: MICROMASS UK LIMITEDInventors: Stevan Bajic, Paul Robert Murray, Mark William Towers
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Publication number: 20180197728Abstract: An ion source is disclosed comprising a nebuliser 1 arranged and adapted to emit a liquid spray, a first target 5 arranged downstream of the nebuliser 1, wherein the liquid spray is arranged to impact upon the first target 5, and a sample target 10 arranged downstream of the first target 5, wherein a sample to be analysed is provided at the sample target 10.Type: ApplicationFiled: December 27, 2017Publication date: July 12, 2018Inventor: Stevan Bajic