Patents by Inventor Stevan Bogdan Jovanovich
Stevan Bogdan Jovanovich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8557518Abstract: The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.Type: GrantFiled: July 28, 2010Date of Patent: October 15, 2013Assignee: IntegenX Inc.Inventors: Stevan Bogdan Jovanovich, Iuliu I. Blaga, Michael Nguyen, William D. Nielsen, Mattias Vangbo
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Patent number: 8551714Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.Type: GrantFiled: February 6, 2012Date of Patent: October 8, 2013Assignee: IntegenX Inc.Inventors: Stevan Bogdan Jovanovich, Iuliu Ioan Blaga
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Patent number: 8476063Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.Type: GrantFiled: June 15, 2010Date of Patent: July 2, 2013Assignee: IntegenX Inc.Inventors: Stevan Bogdan Jovanovich, Iuliu Ioan Blaga
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Patent number: 8431390Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.Type: GrantFiled: November 2, 2011Date of Patent: April 30, 2013Assignee: IntegenX Inc.Inventors: Stevan Bogdan Jovanovich, Iuliu Ioan Blaga
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Patent number: 8431340Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.Type: GrantFiled: October 23, 2009Date of Patent: April 30, 2013Assignee: IntegenX Inc.Inventors: Stevan Bogdan Jovanovich, Iuliu Ioan Blaga
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Publication number: 20130029338Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.Type: ApplicationFiled: February 6, 2012Publication date: January 31, 2013Applicant: INTEGENX INC.Inventors: Stevan Bogdan Jovanovich, Iuliu Ioan Blaga, Allen Boronkay
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Publication number: 20120115189Abstract: The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.Type: ApplicationFiled: July 28, 2010Publication date: May 10, 2012Applicant: IntegenX, Inc.Inventors: Stevan Bogdan Jovanovich, Iuliu I. Blaga, Allen R. Boronkay, Joanne Horn, Michael Van Nguyen, William D. Nielsen, Mattias Vangbo
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Publication number: 20120088249Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.Type: ApplicationFiled: November 2, 2011Publication date: April 12, 2012Applicant: INTEGENX INC.Inventors: Stevan Bogdan Jovanovich, Iuliu I. Blaga
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Publication number: 20110039303Abstract: The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.Type: ApplicationFiled: February 5, 2008Publication date: February 17, 2011Inventors: Stevan Bogdan Jovanovich, Iuliu Ioan Blaga, Allen Boronkay, Joanne Horn, Michael Van Nguyen, William D. Nielsen, Mattias Vangbo
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Publication number: 20100068723Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such asDNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.Type: ApplicationFiled: October 23, 2009Publication date: March 18, 2010Inventors: Stevan Bogdan Jovanovich, Iuliu Ioan Blaga, David Rank
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Patent number: 7138254Abstract: Methods for preparing nanoscale reactions using nucleic acids or proteins are presented. Nucleic acids are captured saturably, yet reversibly, on the internal surface of the reaction chamber, typically a capillary. Excess nucleic acid is removed and the reaction is performed directly within the capillary. Proteins are captured specifically and saturably on the modified inner surface of the reaction chamber, typically a capillary. Excess protein is removed and the reaction is performed directly within the capillary. Devices for effecting the methods of the invention and a system designed advantageously to utilize the methods for high throughput reactions involving nucleic acids or proteins are also provided.Type: GrantFiled: February 7, 2003Date of Patent: November 21, 2006Assignee: GE Healthcare (SV) Corp.Inventors: Stevan Bogdan Jovanovich, Oscar Salas-Solano, Jeng-Thun Li
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Publication number: 20050150765Abstract: Structures and methods that facilitate integration and/or isolation of various functions in a microchip system are disclosed. In one embodiment, the integration of the functions is by a multi-chip, sliding linear valve approach. The chips are in continued physical contact. In a second embodiment, the chips are separated and rejoined when they are moved to the preferred position. Surface coating of the joining edges helps prevent leakage and keeps liquid in the capillary channels for both embodiments. Another embodiment relates to miniature valves. Several designs were disclosed, including the linear, edge-contact sliding valve approach. Method to fabricate very small, high aspect ratio holes in glass was also disclosed, which facilitates the above embodiments.Type: ApplicationFiled: March 9, 2005Publication date: July 14, 2005Inventors: David Roach, Jing Ni, Iuliu-Ioan Blaga, Owe Salven, Stevan Bogdan Jovanovich
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Patent number: 6870185Abstract: Structures and methods that facilitate integration and/or isolation of various functions in a microchip system are disclosed. In one embodiment, the integration of the functions is by a multi-chip, sliding linear valve approach. The chips are in continued physical contact. In a second embodiment, the chips are separated and rejoined when they are moved to the preferred position. Surface coating of the joining edges helps prevent leakage and keeps liquid in the capillary channels for both embodiments. Another embodiment relates to miniature valves. Several designs were disclosed, including the linear, edge-contact sliding valve approach. Method to fabricate very small, high aspect ratio holes in glass was also disclosed, which facilitates the above embodiments.Type: GrantFiled: August 1, 2003Date of Patent: March 22, 2005Assignee: Amersham Biosciences (SV) CorpInventors: David John Roach, Jing Ni, Iuliu-Ioan Blaga, Owe Salvén, Stevan Bogdan Jovanovich
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Publication number: 20040119070Abstract: Structures and methods that facilitate integration and/or isolation of various functions in a microchip system are disclosed. In one embodiment, the integration of the functions is by a multi-chip, sliding linear valve approach. The chips are in continued physical contact. In a second embodiment, the chips are separated and rejoined when they are moved to the preferred position. Surface coating of the joining edges helps prevent leakage and keeps liquid in the capillary channels for both embodiments. Another embodiment relates to miniature valves. Several designs were disclosed, including the linear, edge-contact sliding valve approach. Method to fabricate very small, high aspect ratio holes in glass was also disclosed, which facilitates the above embodiments.Type: ApplicationFiled: August 1, 2003Publication date: June 24, 2004Inventors: David John Roach, Jing Ni, Iuliu-Ioan Blaga, Owe Salven, Stevan Bogdan Jovanovich
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Publication number: 20040017981Abstract: A capillary connector having one or more capillary tubes entering a first end and terminating with an open end at a level face on the opposite side of the connector. The face is held by a coupler and brought into a biased abutment such that the open capillary ends are in fluid communication with the ends of microchannels on an abutting surface. These microchannel ends may be capillary tube ends from a second capillary connector or may be openings of microchannels on a substrate. The connector may be a fiber-optic connector modified to hold capillary tubes. Alternatively, the connector may be a substrate having microchannels extending through the substrate and terminating at a level face on the substrate. The coupler may receive the capillary tube, which passes through the coupler. This coupler may be attached to a substrate surface to allow the capillary connector to be joined to the substrate.Type: ApplicationFiled: April 17, 2003Publication date: January 29, 2004Inventors: Stevan Bogdan Jovanovich, David John Roach, Iuliu-Ioan I. Blaga
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Publication number: 20030224395Abstract: Methods for preparing nanoscale reactions using nucleic acids or proteins are presented. Nucleic acids are captured saturably, yet reversibly, on the internal surface of the reaction chamber, typically a capillary. Excess nucleic acid is removed and the reaction is performed directly within the capillary. Proteins are captured specifically and saturably on the modified inner surface of the reaction chamber, typically a capillary. Excess protein is removed and the reaction is performed directly within the capillary. Devices for effecting the methods of the invention and a system designed advantageously to utilize the methods for high throughput reactions involving nucleic acids or proteins are also provided.Type: ApplicationFiled: February 7, 2003Publication date: December 4, 2003Inventors: Stevan Bogdan Jovanovich, Oscar Salas-Solano, Jeng-Thun Li