Patents by Inventor Stevan Bogdan Jovanovich

Stevan Bogdan Jovanovich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8557518
    Abstract: The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: October 15, 2013
    Assignee: IntegenX Inc.
    Inventors: Stevan Bogdan Jovanovich, Iuliu I. Blaga, Michael Nguyen, William D. Nielsen, Mattias Vangbo
  • Patent number: 8551714
    Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: October 8, 2013
    Assignee: IntegenX Inc.
    Inventors: Stevan Bogdan Jovanovich, Iuliu Ioan Blaga
  • Patent number: 8476063
    Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
    Type: Grant
    Filed: June 15, 2010
    Date of Patent: July 2, 2013
    Assignee: IntegenX Inc.
    Inventors: Stevan Bogdan Jovanovich, Iuliu Ioan Blaga
  • Patent number: 8431390
    Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: April 30, 2013
    Assignee: IntegenX Inc.
    Inventors: Stevan Bogdan Jovanovich, Iuliu Ioan Blaga
  • Patent number: 8431340
    Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
    Type: Grant
    Filed: October 23, 2009
    Date of Patent: April 30, 2013
    Assignee: IntegenX Inc.
    Inventors: Stevan Bogdan Jovanovich, Iuliu Ioan Blaga
  • Publication number: 20130029338
    Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
    Type: Application
    Filed: February 6, 2012
    Publication date: January 31, 2013
    Applicant: INTEGENX INC.
    Inventors: Stevan Bogdan Jovanovich, Iuliu Ioan Blaga, Allen Boronkay
  • Publication number: 20120115189
    Abstract: The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.
    Type: Application
    Filed: July 28, 2010
    Publication date: May 10, 2012
    Applicant: IntegenX, Inc.
    Inventors: Stevan Bogdan Jovanovich, Iuliu I. Blaga, Allen R. Boronkay, Joanne Horn, Michael Van Nguyen, William D. Nielsen, Mattias Vangbo
  • Publication number: 20120088249
    Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
    Type: Application
    Filed: November 2, 2011
    Publication date: April 12, 2012
    Applicant: INTEGENX INC.
    Inventors: Stevan Bogdan Jovanovich, Iuliu I. Blaga
  • Publication number: 20110039303
    Abstract: The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.
    Type: Application
    Filed: February 5, 2008
    Publication date: February 17, 2011
    Inventors: Stevan Bogdan Jovanovich, Iuliu Ioan Blaga, Allen Boronkay, Joanne Horn, Michael Van Nguyen, William D. Nielsen, Mattias Vangbo
  • Publication number: 20100068723
    Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such asDNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
    Type: Application
    Filed: October 23, 2009
    Publication date: March 18, 2010
    Inventors: Stevan Bogdan Jovanovich, Iuliu Ioan Blaga, David Rank
  • Patent number: 7138254
    Abstract: Methods for preparing nanoscale reactions using nucleic acids or proteins are presented. Nucleic acids are captured saturably, yet reversibly, on the internal surface of the reaction chamber, typically a capillary. Excess nucleic acid is removed and the reaction is performed directly within the capillary. Proteins are captured specifically and saturably on the modified inner surface of the reaction chamber, typically a capillary. Excess protein is removed and the reaction is performed directly within the capillary. Devices for effecting the methods of the invention and a system designed advantageously to utilize the methods for high throughput reactions involving nucleic acids or proteins are also provided.
    Type: Grant
    Filed: February 7, 2003
    Date of Patent: November 21, 2006
    Assignee: GE Healthcare (SV) Corp.
    Inventors: Stevan Bogdan Jovanovich, Oscar Salas-Solano, Jeng-Thun Li
  • Publication number: 20050150765
    Abstract: Structures and methods that facilitate integration and/or isolation of various functions in a microchip system are disclosed. In one embodiment, the integration of the functions is by a multi-chip, sliding linear valve approach. The chips are in continued physical contact. In a second embodiment, the chips are separated and rejoined when they are moved to the preferred position. Surface coating of the joining edges helps prevent leakage and keeps liquid in the capillary channels for both embodiments. Another embodiment relates to miniature valves. Several designs were disclosed, including the linear, edge-contact sliding valve approach. Method to fabricate very small, high aspect ratio holes in glass was also disclosed, which facilitates the above embodiments.
    Type: Application
    Filed: March 9, 2005
    Publication date: July 14, 2005
    Inventors: David Roach, Jing Ni, Iuliu-Ioan Blaga, Owe Salven, Stevan Bogdan Jovanovich
  • Patent number: 6870185
    Abstract: Structures and methods that facilitate integration and/or isolation of various functions in a microchip system are disclosed. In one embodiment, the integration of the functions is by a multi-chip, sliding linear valve approach. The chips are in continued physical contact. In a second embodiment, the chips are separated and rejoined when they are moved to the preferred position. Surface coating of the joining edges helps prevent leakage and keeps liquid in the capillary channels for both embodiments. Another embodiment relates to miniature valves. Several designs were disclosed, including the linear, edge-contact sliding valve approach. Method to fabricate very small, high aspect ratio holes in glass was also disclosed, which facilitates the above embodiments.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: March 22, 2005
    Assignee: Amersham Biosciences (SV) Corp
    Inventors: David John Roach, Jing Ni, Iuliu-Ioan Blaga, Owe Salvén, Stevan Bogdan Jovanovich
  • Publication number: 20040119070
    Abstract: Structures and methods that facilitate integration and/or isolation of various functions in a microchip system are disclosed. In one embodiment, the integration of the functions is by a multi-chip, sliding linear valve approach. The chips are in continued physical contact. In a second embodiment, the chips are separated and rejoined when they are moved to the preferred position. Surface coating of the joining edges helps prevent leakage and keeps liquid in the capillary channels for both embodiments. Another embodiment relates to miniature valves. Several designs were disclosed, including the linear, edge-contact sliding valve approach. Method to fabricate very small, high aspect ratio holes in glass was also disclosed, which facilitates the above embodiments.
    Type: Application
    Filed: August 1, 2003
    Publication date: June 24, 2004
    Inventors: David John Roach, Jing Ni, Iuliu-Ioan Blaga, Owe Salven, Stevan Bogdan Jovanovich
  • Publication number: 20040017981
    Abstract: A capillary connector having one or more capillary tubes entering a first end and terminating with an open end at a level face on the opposite side of the connector. The face is held by a coupler and brought into a biased abutment such that the open capillary ends are in fluid communication with the ends of microchannels on an abutting surface. These microchannel ends may be capillary tube ends from a second capillary connector or may be openings of microchannels on a substrate. The connector may be a fiber-optic connector modified to hold capillary tubes. Alternatively, the connector may be a substrate having microchannels extending through the substrate and terminating at a level face on the substrate. The coupler may receive the capillary tube, which passes through the coupler. This coupler may be attached to a substrate surface to allow the capillary connector to be joined to the substrate.
    Type: Application
    Filed: April 17, 2003
    Publication date: January 29, 2004
    Inventors: Stevan Bogdan Jovanovich, David John Roach, Iuliu-Ioan I. Blaga
  • Publication number: 20030224395
    Abstract: Methods for preparing nanoscale reactions using nucleic acids or proteins are presented. Nucleic acids are captured saturably, yet reversibly, on the internal surface of the reaction chamber, typically a capillary. Excess nucleic acid is removed and the reaction is performed directly within the capillary. Proteins are captured specifically and saturably on the modified inner surface of the reaction chamber, typically a capillary. Excess protein is removed and the reaction is performed directly within the capillary. Devices for effecting the methods of the invention and a system designed advantageously to utilize the methods for high throughput reactions involving nucleic acids or proteins are also provided.
    Type: Application
    Filed: February 7, 2003
    Publication date: December 4, 2003
    Inventors: Stevan Bogdan Jovanovich, Oscar Salas-Solano, Jeng-Thun Li