Abstract: The present invention provides devices and methods for handling and processing a filter or other matrix punch comprising a sample of interest in order to prevent loss of the punch and to improve ease of handling. In one aspect, the present invention provides a device comprising a first element, which holds a punch, coupled to a second element, which contributes to holding the punch in the first element, with reservoirs above and below the punch. The devices and methods can be used manually in single-channel and multi-channel formats or can be used in an automated processor, such as a robotic processor. Kits are also provided.