Abstract: Disclosed herein is a device that standardizes and automates pain testing in laboratory rodents by providing computer-controlled aiming and delivery of various somatosensory stimuli, and precisely measuring the evoked responses. For photostimuli, red light is incorporated into the light path and its reflectance off the paw is measured (at ?1 kHz) by a photodetector mounted on the device. The reflectance signal changes rapidly when the target paw moves, thus enabling automated measurement of withdrawal latencies with millisecond precision. A camera mounted on the device, below the mouse, provides video for aiming and for behavior analysis before, during and after stimulation. The device can be aimed manually or automatically using artificial intelligence (AI), in the latter case, the target paw is identified and tracked by a pre-trained neural network, and real-time information about paw location is used to command motorized linear actuators to move the stimulator and to initiate stimulation.