Abstract: A kidney perfusion catheter assembly is disclosed having an introducer catheter, a renal artery seal, a perfusion tip, and a guide wire. The perfusion catheter provides a flow of supplemental blood to increase the local blood pressure in the renal artery and to perfuse the kidney. The introducer catheter is maneuvered through the femoral artery to the aorta and positioned at the branch of a renal artery. The perfusion catheter tip is telescoped from the distal end of the introducer catheter into the renal artery. A blood pump attached to the proximal end of the perfusion catheter assembly provides a flow of blood that streams from the perfusion catheter tip into the renal artery. This stream of blood increases the pressure and volume of the blood flowing through the renal artery. The catheter includes a seal to block the opening of the renal artery to prevent the runoff of the blood from the renal artery into the aorta.