Patents by Inventor Steve C. S. Chang

Steve C. S. Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conjugation of ligand to immobilized protein in organic solvent
    Patent number: 5817527
    Abstract: A new method for immobilization of small molecules on solid supports via a macromolecular spacer has been developed. A protein or another macromolecule is first immobilized in an aqueous medium, and the solid support is than washed with an organic solvent. The small molecule is coupled in an organic medium, followed by organic medium washes. The new solid phases are useful for affinity purifications, immunoassays and other binding assays, and for selection of binders by panning procedures.
    Type: Grant
    Filed: November 6, 1995
    Date of Patent: October 6, 1998
    Assignee: Chiron Diagnostics Corporation
    Inventors: Uri Piran, Steve C. S. Chang, William J. Riordan, James W. Peterson, Edward M. Sunshine
  • Nucleophilic polysubstituted aryl acridinium ester conjugates uses thereof
    Patent number: 5538901
    Abstract: This invention is directed to the novel assay methods utilizing nucleophilic polysubstituted aryl acridinium ester conjugates as the tracers. Conjugates prepared by covalent coupling of novel nucleophilic polysubstituted aryl acridinium esters with biological compounds including small organic molecules such as Vitamin B12, folate, cortisol, estradiol, and thromboxane B2, were found useful in the development of highly sensitive assays for the analytes of diagnostic interest.
    Type: Grant
    Filed: August 18, 1994
    Date of Patent: July 23, 1996
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Say-Jong Law, Steve C. S. Chang, Carol K. Klukas, Christine A. Vitkauskas
  • Polysubstituted aryl acridinium esters
    Patent number: 5110932
    Abstract: The present invention relates to novel acridinium esters which are useful as luminescent labels in specific binding assays such as immunoassays or nucleic acid hybridization assays. More particularly, polysubstituted aryl acridinium esters are highly stable labels for use in a chemiluminescent immunoassay.
    Type: Grant
    Filed: March 1, 1990
    Date of Patent: May 5, 1992
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Say-Jong Law, Steve C. S. Chang, Stephen A. Palmacci, Roger S. Cubicciotti
  • Method for enhancing signal release from liposomes using water-miscible alcohols
    Patent number: 5093270
    Abstract: A method for releasing encapsulated marker molecules from within liposomes comprises contracting the liposomes with an effective amount of a water-miscible alcohol. The chemiluminescence of acridinium esters is enhanced by oxidizing the acridinium ester in the presence of an effective amount of a water-miscible alcohol.
    Type: Grant
    Filed: May 24, 1989
    Date of Patent: March 3, 1992
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Steve C. S. Chang, Say-Jong Law
  • Method for enhancement of chemiluminescence
    Patent number: 4927769
    Abstract: A method for enhancing the chemiluminescent signal of an acridinium ester in a chemiluminescent reaction which comprises oxidizing the acridinium ester in the presence of an enhancer selected from the group consisting of: (a) a cationic surfactant; (b) a nonionic surfactant; and (c) a sulfated primary alcohol.
    Type: Grant
    Filed: July 8, 1987
    Date of Patent: May 22, 1990
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Steve C. S. Chang, Thomas E. Miller
  • Polysubstituted aryl acridinium esters
    Patent number: 4918192
    Abstract: The present invention relates to novel acridinium esters which are useful as luminescent labels in specific binding assays such as immunoassays or nucleic acid hybridization assays. More particularly, polysubstituted aryl acridinium esters are highly stable labels for use in a chemiluminescent immunoassay.
    Type: Grant
    Filed: December 14, 1987
    Date of Patent: April 17, 1990
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Say-Jong Law, Steve C. S. Chang, Stephen A. Palmacci, Roger S. Cubicciotti
  • Method for determining thyroxine uptake
    Patent number: 4824777
    Abstract: A method for determining thyroxine uptake of a sample serum comprising: (a) incubating the sample serum with solid phase thyroxine and labeled anti-TBG antibody; (b) separating the solid phase from the unbound labeled antibody; (c) measuring the amount of label associated with the solid phase; and (d) calculating the thyroxide uptake ratio of the sample serum by relating the measurement of step (c) to a measurement of a reference serum.
    Type: Grant
    Filed: July 8, 1987
    Date of Patent: April 25, 1989
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Steve C. S. Chang, Thomas E. Miller, Elizabeth K. Krodel
  • Polysubstituted aryl acridinium esters
    Patent number: 4745181
    Abstract: The present invention relates to novel acridinium esters which are useful as luminescent labels in specific binding assays such as immunoassays or nucleic acid hybridization assays. More particularly, polysubstituted aryl acridinium esters are highly stable labels for use in a chemiluminescent immunoassay.
    Type: Grant
    Filed: October 6, 1986
    Date of Patent: May 17, 1988
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Say-Jong Law, Steve C. S. Chang, Stephen A. Palmacci, Roger S. Cubicciotti