Patents by Inventor Steve Ehren Glenn

Steve Ehren Glenn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OPTIMIZED PROTEIN FUSIONS AND LINKERS
    Publication number: 20250122491
    Abstract: This invention pertains to optimized protein fusion linkers for creating multi-functional chimeric proteins and methods of using the same. Additionally, the invention pertains to chimeric proteins for use in guided endonuclease systems and methods of using the same.
    Type: Application
    Filed: October 7, 2024
    Publication date: April 17, 2025
    Applicant: Integrated DNA Technologies, Inc.
    Inventors: Michael Allen Collingwood, Steve Ehren Glenn, Christopher Anthony Vakulskas
  • Optimized protein fusions and linkers
    Patent number: 12152258
    Abstract: This invention pertains to optimized protein fusion linkers for creating multi-functional chimeric proteins and methods of using the same. Additionally, the invention pertains to chimeric proteins for use in guided endonuclease systems.
    Type: Grant
    Filed: April 20, 2021
    Date of Patent: November 26, 2024
    Assignee: INTEGRATED DNA TECHNOLOGIES, INC.
    Inventors: Michael Allen Collingwood, Steve Ehren Glenn, Christopher Anthony Vakulskas
  • UBIQUITIN VARIANT WITH HIGH AFFINITY FOR BINDING 53BP1 REDUCES THE AMOUNT OF AAV NEEDED TO ACHIEVE HIGH RATES OF HDR
    Publication number: 20240059747
    Abstract: The present invention pertains to a tag-free CM1 polypeptide and methods for improving homology directed repair (HDR) in a recipient cell using the same. Preferred donor template delivery vehicles include Adeno virus-associated vectors for delivering donor templates, and a preferred tag-free CM1 polypeptide called CM1tf. Isolated nucleic acids encoding tag-free CM1 polypeptides are also provided.
    Type: Application
    Filed: August 15, 2023
    Publication date: February 22, 2024
    Inventors: Steve Ehren Glenn, Michael Allen Collingwood, Christopher Anthony Vakulskas
  • UBIQUITIN VARIANTS WITH IMPROVED AFFINITY FOR 53BP1
    Publication number: 20230135471
    Abstract: The present invention pertains to ubiquitin polypeptide variants (Ubvs) having improved affinity for 53BP1 relative to 53 ubiquitin polypeptide or i53 ubiquitin polypeptide, wherein the resultant interaction between the Ubvs and 53BP1 promotes increased homology directed repair of DNA double-strand break sites. Methods of suppressing 53BP1 recruitment to DNA double-strand break sites, increasing homologous recombination, increasing gene targeting, and editing a gene in a cell using a CRISPR system are provided with the Ubvs. Compositions and kits of Ubvs are also provided.
    Type: Application
    Filed: September 24, 2022
    Publication date: May 4, 2023
    Inventors: Christopher Anthony Vakulskas, Nicole Mary Bode, Steve Ehren Glenn, Liyang Zhang
  • OPTIMIZED PROTEIN FUSIONS AND LINKERS
    Publication number: 20230049003
    Abstract: This invention pertains to optimized protein fusion linkers for creating multi-functional chimeric proteins and methods of using the same. Additionally, the invention pertains to chimeric proteins for use in guided endonuclease systems.
    Type: Application
    Filed: April 20, 2021
    Publication date: February 16, 2023
    Inventors: Michael Allen Collingwood, Steve Ehren Glenn, Christopher Anthony Vakulskas