Abstract: Described herein is a method for producing photochromic silicone hydrogel contact lenses in a relatively efficient and consistent manner from a polymerizable composition under a controlled thermal curing scheme. The main polymerizable components in the polymerizable composition are a high radical-reactive hydrophilic (meth)acrylamido monomer, a high radical-reactive siloxane-containing (meth)acrylamido monomer, and a polysiloxane vinylic crosslinker(s) free of low-reactive ethylenically unsaturated group as the main crosslinker. The thermal free radical initiator having a 10 hour half-life temperature (T10h?) of from about 50° C. to about 90° C. The controlled thermal curing scheme includes maintaining a first curing temperature of from about (T10h??20)° C. to about T10h?° C. for a first curing time and maintaining a second curing temperature of from about (T10h?+10)° C. to about (T10h?+35)° C. for a second curing time.

Abstract: The invention provides a class of photochromic polydiorganosiloxane vinylic crosslinkers. Each of the photochromic polydiorganosiloxane vinylic crosslinkers of the invention comprise (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and photochromic siloxane unit having one methyl substituent and one organic substituent having a photochromic moiety that capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light; (2) two terminal ethylenically-unsaturated groups. The invention also provides a soft photochromic contact lens, especially a photochromic silicone hydrogel contact lens, which comprises a crosslinked polymeric material comprising repeating units of at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers.

Abstract: The invention is generally related to a soft hydrogel ocular insert that is composed of at least one hydrogel material in fully hydrated state and can be comfortable for wearing. The hydrogel material comprises polymer chains, which are derived from at least one arylborono-containing hydrophilic copolymer and at least one mucoadhesive polymer, and cyclic boronic ester crosslinks for crosslinking those mucoadhesive polymer chains and arylborono-containing hydrophilic copolymer chains to form a 3-dimensional polymer network. Those cyclic boronic ester crosslinks can be hydrolyzed slowly in the tear of the eyes of a patient, resulting in the disintegration (dissolution) of the 3-dimensional polymer network and thereby providing mucoadhesisve polymers and optionally drugs impregnated in the hydrogel ocular insert in a controlled manner.

Abstract: The invention provides a method for imaging and thickness determination of coatings on coated contact lenses. The method comprises selectively staining a negatively-charged-groups-containing coating over the lens body of a coated contact lens by immersing the coated contact lens in an aqueous solution comprising a fluorescently-labeled polycationic polymer and having a pH of from about 6.5 to 8.0; orthogonally cutting the selectively-stained coated contact lens; and determining the thickness of the coating on the coated contact lens. In addition, the invention provides a method for selecting a candidate coating material comprising negatively charged groups for applying a coating with a desired thickness onto silicone hydrogel contact lenses and for optimizing a coating process for producing coated silicone hydrogel contact lenses with a desired thickness coating thereon.

Abstract: Systems and methods are provided for management of network segments that cross geographic regions and/or other types of network divisions in a cloud-based network environment. A cloud-based network provider's geographically-dispersed network infrastructure may serve as the core of a client's private wide area network, and the client may define isolated segments to which other networks (virtual private clouds, virtual private networks, etc.) may be attached. The various segments may remain logically isolated from each other even when implemented across some or all of the same regions—and using the same physical and/or virtual routing components—as other segments of the same client and/or other clients.

Abstract: A pair of virtual routers is configured. In response to programmatic requests, dynamic transfer of routing information between the routers in accordance with configuration settings indicated by a client is enabled. The routing information is associated with a set of isolated networks to which the virtual routers are attached. A network packet originating at an address in a first isolated network is transmitted to an address in a second isolated network using a route determined from routing information transmitted between the virtual routers according to the configuration settings.

Abstract: An indication of a set of premises between which network traffic is to be routed via a private fiber backbone of a provider network is obtained. Respective virtual routers are configured for a first premise and a second premise, and connectivity is established between the virtual routers and routing information sources at the premises. Contents of at least one network packet originating at the first premise are transmitted to the second premise via the private fiber backbone using routing information obtained at the virtual routers from the routing information source at the second premise.

Abstract: An indication of a set of premises between which network traffic is to be routed via a private fiber backbone of a provider network is obtained. Respective virtual routers are configured for a first premise and a second premise, and connectivity is established between the virtual routers and routing information sources at the premises. Contents of at least one network packet originating at the first premise are transmitted to the second premise via the private fiber backbone using routing information obtained at the virtual routers from the routing information source at the second premise.

Abstract: A pair of virtual routers is configured. In response to programmatic requests, dynamic transfer of routing information between the routers in accordance with configuration settings indicated by a client is enabled. The routing information is associated with a set of isolated networks to which the virtual routers are attached. A network packet originating at an address in a first isolated network is transmitted to an address in a second isolated network using a route determined from routing information transmitted between the virtual routers according to the configuration settings.

Abstract: A message indicating an auxiliary task associated with traffic transmitted via a virtual router between a pair of isolated networks is received at an offloading device. A stack multiplexer at the offloading device selects a protocol stack instance to process the message. A result of the auxiliary task is obtained by the multiplexer from the selected protocol stack instance and transmitted to the virtual router, where it is used to transmit a packet between the isolated networks.

Abstract: An indication of a set of premises between which network traffic is to be routed via a private fiber backbone of a provider network is obtained. Respective virtual routers are configured for a first premise and a second premise, and connectivity is established between the virtual routers and routing information sources at the premises. Contents of at least one network packet originating at the first premise are transmitted to the second premise via the private fiber backbone using routing information obtained at the virtual routers from the routing information source at the second premise.

Abstract: A category of auxiliary tasks (such as routing configuration management or packet content transformation) associated with transmission of network packets between sets of network endpoints is determined. A virtual router is configured to transmit the packets between the sets of network endpoints. Connectivity is enabled between the virtual router and an auxiliary task offloading resource. Results of an auxiliary task performed at the offloading resource are used to transmit at least some packets between the sets of network endpoints.