Abstract: Human MAX genes are identified as modulators of the AXIN pathway, and thus are therapeutic targets for disorders associated with defective AXIN function. Methods for identifying modulators of AXIN, comprising screening for agents that modulate the activity of MAX are provided.

Abstract: The disclosure relates to tubular, non-round composite paperboard container bodies having at least one wall portion defined by radially inverse curvature, and at least a second wall portion that is outwardly curved. In one preferred embodiment, the container body includes at least two body wall portions of inverse curvature, which are positioned in an opposed relationship. The two opposed body wall portions having inverse curvature provide an integral handle allowing easy grasping of the container body by the hand of a consumer, i.e. by the opposed thumb and fingers of a consumer.