Patents by Inventor Steve Helmke

Steve Helmke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of protein kinase C-related kinase (PRK) as a treatment for cardiac hypertrophy and heart failure
    Publication number: 20050283841
    Abstract: The present invention provides for methods of treating and preventing cardiac hypertrophy and heart failure. MEF-2 and Class II HDACs have been shown to have a major role in cardiac hypertrophy and heart disease, and inhibition of class II HDAC's has been shown to have a beneficial, anti-hypertrophic effect. The present invention provides a link between MEF-2 and class II HDAC's, a kinase known as PRK. The present invention further demonstrates that inhibitors of PRK inhibit cardiac hypertrophy and heart disease by inhibiting, in part, the fetal cardiac gene expression and cellular reorganization that occurs when MEF-2 dependent transcription is activated.
    Type: Application
    Filed: February 2, 2005
    Publication date: December 22, 2005
    Inventors: Timothy McKinsey, Eric Olson, Brooke Harrison, Igor Rybkin, Steve Helmke
  • Method for identifying neurite-growth promoting agents
    Patent number: 6566047
    Abstract: The present invention provides methods of identifying and using compounds that modulate cell motility. Such compounds can be used to inhibit cancer cell metastasis or promote neurite growth and regenaration. The methods generally relate to the repellent-receptor signalling pathway that controls cellular attachment and detachment to a substratum.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: May 20, 2003
    Assignee: The Regents of the University of Colorado
    Inventors: Karl Pfenninger, Becky De La Houssaye, Keith Mikule, Steve Helmke, Harry Drabkin