Abstract: The present invention encompasses compounds of formula (I) wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V, W, L and E have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: A floor finishing composition comprises water, polymer of ethylenic unsaturated monomers having a glass transition temperature of at least 90#C as measured using differential scanning calorimetry according to the ASTM Method D3418-15, coalescing solvent, and polyvalent metal crosslinking agent. The ethylenic unsaturated monomers comprise methyl (meth)acrylate, ?,?-unsaturated carboxylic acid, aromatic vinyl monomer, and no more than 25% by weight of ?,?-unsaturated carboxylic ester of C2-10 alcohol based on total weight of the monomers. The ethylenic unsaturated monomers may comprise from about 14% to about 18% by weight of the ?,?-unsaturated carboxylic acid based on total weight of the monomers. The amount of coalescing solvent in the floor finishing composition may be more than 6% by weight based on total weight of the floor finishing composition.

Abstract: A method for determining and displaying the security state of data is disclosed where a third party operates a database having a computer storage medium for storage of non-transitory data. A first party stores data on the third party database. A website interface is established by the first party to access the data over the Internet. A user is allowed access to the data stored on the third party database through the website interface. A set of validation rules are configured to be applied to the data. Compliance or non-compliance with a set of validation rules determines a security state of the data. The security state of the data is determined based upon the compliance of the data with the set of validation rules. An indicator representative of the security state of the data is sent to the website interface of the first party and displayed to the user.

Abstract: Functionalized graphene is provided. The functionalized graphene is graphene onto whose surface one or more active molecules are grafted, the active molecule includes a plurality of terminal functional groups, and the plurality of terminal functional groups include at least two active functional groups. Because the active functional groups can chemically react with molecules in silicone oil, the functionalized graphene can evenly dissolve in the silicone oil, so that polyorganosiloxane prepared by using the functionalized graphene has good heat conduction performance. In addition, this application further provides a preparation method of the functionalized graphene and corresponding polyorganosiloxane.

Abstract: A computer implemented system and method, and a computer program product, for collecting and displaying crowd sourced health status information. For example, the method may include receiving and storing individual identification information for each of a plurality of individuals, and receiving and storing, for each of the plurality of identified individuals, group affiliation information in association with individual identification information. The method also may include receiving and storing health status information, which identifies a medical condition associated with an individual. The method also may include determining that at least another individual has the medical condition, and displaying information comprising a number of the individuals that have the medical condition.

Abstract: A system and method for providing an augmented reality environment in which the environmental mapping process is decoupled from the localization processes performed by one or more mobile devices is described. In some embodiments, an augmented reality system includes a mapping system with independent sensing devices for mapping a particular real-world environment and one or more mobile devices. Each of the one or more mobile devices utilizes a separate asynchronous computing pipeline for localizing the mobile device and rendering virtual objects from a point of view of the mobile device. This distributed approach provides an efficient way for supporting mapping and localization processes for a large number of mobile devices, which are typically constrained by form factor and battery life limitations.

Abstract: A system and method for providing an augmented reality environment in which the environmental mapping process is decoupled from the localization processes performed by one or more mobile devices is described. In some embodiments, an augmented reality system includes a mapping system with independent sensing devices for mapping a particular real-world environment and one or more mobile devices. Each of the one or more mobile devices utilizes a separate asynchronous computing pipeline for localizing the mobile device and rendering virtual objects from a point of view of the mobile device. This distributed approach provides an efficient way for supporting mapping and localization processes for a large number of mobile devices, which are typically constrained by form factor and battery life limitations.

Abstract: A three-way call detection system and method for detecting continuous noise indicative of a an attempt to circumvent existing three-way call detection systems and methods. The continuous noise detection system and method may be used in conjunction with any existing three-way call detection system and method, including for example, a system and method that monitors the active communications of the telephone management system for pulses of energy indicative of a three-way call.

Abstract: A system and method for providing an augmented reality environment in which the environmental mapping process is decoupled from the localization processes performed by one or more mobile devices is described. In some embodiments, an augmented reality system includes a mapping system with independent sensing devices for mapping a particular real-world environment and one or more mobile devices. Each of the one or more mobile devices utilizes a separate asynchronous computing pipeline for localizing the mobile device and rendering virtual objects from a point of view of the mobile device. This distributed approach provides an efficient way for supporting mapping and localization processes for a large number of mobile devices, which are typically constrained by form factor and battery life limitations.

Abstract: A touch sensor provides frames of touch sensor data, as the touch sensor is sampled over time. Spatial and temporal features of the touch sensor data from a plurality of frames, and contacts and attributes of the contacts in previous frames, are processed to identify contacts and attributes of the contacts in a current frame. Attributes of the contacts can include, whether the contact is reliable, shrinking, moving, or related to a fingertip touch. The characteristics of contacts can include information about the shape and rate of change of the contact, including but not limited to a sum of its pixels, its shape, size and orientation, motion, average intensities and aspect ratio.

Abstract: Apparatus for rapid discharge of one or more fire extinguishing agent(s). The apparatus includes a sealed container forming an interior volume in communication with a rapidly opening valve assembly. The interior volume contains fire extinguishing agent(s), super-pressurised by a gas such as nitrogen. A portion of the nitrogen is dissolved into the fire extinguishing agent(s). When an incident is detected which requires the discharge of the fire extinguishing agent(s) the valve is opened. Opening the valve causes rapid dissolution of the nitrogen from the fire extinguishing agent(s), forming a two-phase mixture (like a foam or mousse) which substantially fills the volume and causing the discharge of fire extinguishing agent(s) from the valve assembly.

Abstract: A sight for a handheld weapon includes an electronic component that is powered by a power source. The sight includes an electronic controller and a motion detector. When the sight is moved, the motion detector generates signals and the electronic controller receives the signals. The electronic controller determines whether power should be supplied to the electronic component based on the received signals.

Abstract: This invention relates to the identification of a nucleic acid molecule. In particular, this invention relates to a method of using an oligonucleotide designed to a variable region of a nucleic acid molecule to identify A nucleic acid molecule.

Abstract: A method of mounting a hubcap on a wheel that involves providing a wheel having an annular hub surrounding an axis of rotation, the hub including a first periphery extending along the circumference of a circle surrounding the axis of rotation and a second periphery spaced from the circumference of the circle, providing a hubcap having a top wall and a cylindrical sidewall extending from the top wall, the cylindrical sidewall having an end edge spaced from the top wall and a circumferential flange projecting from the cylindrical side wall, the circumferential flange having a sidewall and an alignment tab projecting from the sidewall, aligning the hubcap alignment tab with the second periphery, placing the hubcap sidewall against the hub and the alignment tab over the second periphery, and clamping the hubcap to the wheel. Also a wheel (10, 80) including a hubcap (30, 90) and a clamp (50).

Abstract: Disclosed is an improved three-way call detection system and method for use with a telephone management system. Specifically, a three-way call detection system and method for detecting continuous noise indicative of a an attempt to circumvent existing three-way call detection systems and methods. The continuous noise detection system and method may be used in conjunction with any existing three-way call detection system and method, including for example, a system and method that monitors the active communications of the telephone management system for pulses of energy indicative of a three-way call.

Abstract: A method of mounting a hubcap on a wheel that involves providing a wheel having an annular hub surrounding an axis of rotation, the hub including a first periphery extending along the circumference of a circle surrounding the axis of rotation and a second periphery spaced from the circumference of the circle, providing a hubcap having a top wall and a cylindrical sidewall extending from the top wall, the cylindrical sidewall having an end edge spaced from the top wall and a circumferential flange projecting from the cylindrical side wall, the circumferential flange having a sidewall and an alignment tab projecting from the sidewall, aligning the hubcap alignment tab with the second periphery, placing the hubcap sidewall against the hub and the alignment tab over the second periphery, and clamping the hubcap to the wheel. Also a wheel (10, 80) including a hubcap (30, 90) and a clamp (50).

Abstract: An aircraft wheel noise reduction fairing (8) includes a disk (10) having first and second sides (12, 14) and a plurality of circumferentially disposed openings (16) between the first side (12) and the second side (14) and at least one mesh structure (24, 26) connected to the second side (14) of the disk (10) overlying the plurality of circumferentially disposed openings (16). Also the combination of an aircraft wheel (30) and a noise reduction fairing (8) wherein the aircraft wheel (30) includes a hub (32) surrounding a wheel axis of rotation (34), a web (36) projecting from the hub (32) and a cylindrical wall (40) having an inner surface (42) and an outer surface (44) connected to the web (36) and surrounding the axis of rotation (34).

Abstract: Apparatus 11 for rapid discharge of one or more fire extinguishing agent(s) comprises a sealed container 13 forming an interior volume 15 in communication with a rapidly opening valve assembly 17. The interior volume contains fire extinguishing agent(s), super-pressurised by a gas such as nitrogen. A portion of the nitrogen is dissolved into the fire extinguishing agent(s). When an incident is detected which requires the discharge of the fire extinguishing agent(s) the valve 17 is opened. Opening the valve 17 causes rapid dissolution of the nitrogen from the fire extinguishing agent(s), forming a two-phase mixture (like a foam or mousse) which substantially fills the volume 15 and causing the discharge of fire extinguishing agent(s) from the valve assembly 17.