Patents by Inventor Steve Jianrong Zhou

Steve Jianrong Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chiral phosphines for palladium-catalyzed asymmetric ?-arylation of ester enolates to produce tertiary stereocenters in high enantioselectivity
    Patent number: 9512155
    Abstract: The disclosure provides new and improved methods for the Pd-catalyzed asymmetric ?-arylation of ester compounds, which produce the corresponding ?-aryl moiety in high enantioselectivity (generally >90% ee). The present methods utilize a palladium catalyst supported by new (R)—H8-BINOL-derived monophosphine ligands. The method is applicable to a wide variety of aryl triflate substrates having variations in both electronic and steric properties. These aryl triflate substrates react with various ?-alkyl (Z)- and/or (E)-0-trimethylsilyl ketene acetals in the presence of a Pd catalyst, (R)—H8-BINOL-derived monophosphine ligand, and a mild activator, for example, LiOAC, to provide the asymmetric ?-arylation of ester compounds in high ee.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: December 6, 2016
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Steve Jianrong Zhou, Zhiyan Huang
  • CHIRAL PHOSPHINES FOR PALLADIUM-CATALYZED ASYMMETRIC ALPHA-ARYLATION OF ESTER ENOLATES TO PRODUCE TERTIARY STEREOCENTERS IN HIGH ENANTIOSELECTIVITY
    Publication number: 20150166586
    Abstract: The disclosure provides new and improved methods for the Pd-catalyzed asymmetric ?-arylation of ester compounds, which produce the corresponding ?-aryl moiety in high enantioselectivity (generally >90% ee). The present methods utilize a palladium catalyst supported by new (R)—H8-BINOL-derived monophosphine ligands. The method is applicable to a wide variety of aryl triflate substrates having variations in both electronic and steric properties. These aryl triflate substrates react with various ?-alkyl (Z)- and/or (E)-0-trimethylsilyl ketene acetals in the presence of a Pd catalyst, (R)—H8-BINOL-derived monophosphine ligand, and a mild activator, for example, LiOAC, to provide the asymmetric ?-arylation of ester compounds in high ee.
    Type: Application
    Filed: August 17, 2012
    Publication date: June 18, 2015
    Applicant: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Steve Jianrong Zhou, Zhiyan Huang