Abstract: The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient.

Abstract: The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient.

Abstract: The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient.

Abstract: The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient.

Abstract: A controller is for a vehicle wetting system including a fluid supply and a delivery line having an inlet connected with the supply and an outlet located to direct fluid onto a compacting drum. The controller includes a regulator configured to adjust a fluid flow rate through the outlet. A speed sensor connected with the vehicle senses vehicle speed. Further, a logic circuit connected with the sensor and the regulator automatically operates the regulator such that the regulator adjusts the flow rate to be generally proportional to the vehicle speed. Alternatively, the logic circuit permits flow through the outlet for a predetermined drum displacement and alternately interrupts flow for a predetermined period of time. The regulator is either a shunt line and a valve adjusting flow through the shunt line to adjust flow through the outlet or a pump regulator controlling flow from a pump in the delivery line.

Abstract: A controller is for a vehicle wetting system including a fluid supply and a delivery line having an inlet connected with the supply and an outlet located to direct fluid onto a compacting drum. The controller includes a regulator configured to adjust a fluid flow rate through the outlet. A speed sensor connected with the vehicle senses vehicle speed. Further, a logic circuit connected with the sensor and the regulator automatically operates the regulator such that the regulator adjusts the flow rate to be generally proportional to the vehicle speed. Alternatively, the logic circuit permits flow through the outlet for a predetermined drum displacement and alternately interrupts flow for a predetermined period of time. The regulator is either a shunt line and a valve adjusting flow through the shunt line to adjust flow through the outlet or a pump regulator controlling flow from a pump in the delivery line.