Abstract: Anastomotic methods and devices for placing a target vessel in fluid communication with a target vessel. A conduit includes an attachment portion adapted to be secured to a target vessel in fluid communication with the lumen of the vessel. The target vessel wall is sandwiched between first and second components of the attachment portion to provide both a secure and sealed connection. One component is placed in the vessel lumen against the interior surface of the wall and has an outlet that directs blood into the target vessel. This component is elongated, e.g., elliptical or rectangular, such that a minimum amount of material is present at the outlet. This results in the outlet having a diameter that substantially maintains much of the cross-sectional area of the native target vessel.

Abstract: Improved systems, devices, and methods for deployment of endoluminal prostheses within the lumens of the body withdraw a sheath from over the tightly compressed prostheses using an actuation mechanism having a variable mechanical advantage. This allows movement of the sheath to be initiated with ease and accuracy. Once deployment is safely underway, and after static frictional forces have been overcome, the remainder of the deployment may proceed more rapidly without significantly degrading overall safety or ease of use of the delivery system. In another improvement, the handle for the actuation mechanism may rotate about an axis parallel to the axis of the sheath. An outer tube may be provided around the sheath and coupled to the prosthesis restraining member within the sheath.