Patents by Inventor Steve M. Helmke

Steve M. Helmke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry
    Publication number: 20040119010
    Abstract: The present invention provides for methods of quantitating the amounts of proteins or peptides, including those that are closely related isoforms, using matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS). Measurement of protein concentrations in vivo has been extremely difficult and problematic, and protein concentrations have not been shown to correlate well with mRNA levels, the standard used in the past. The present invention overcomes the deficiencies of prior methodologies by taking advantage of MALDI-TOF-MS technology and applying it to proteins and peptides in a way that allows for accurate, quantitative measurement in vivo of protein or peptide concentrations.
    Type: Application
    Filed: October 30, 2003
    Publication date: June 24, 2004
    Applicant: The Regents of the University of Colorado
    Inventors: M. Benjamin Perryman, Steve M. Helmke, Mark W. Duncan