Patents by Inventor Steve R. Gonda
Steve R. Gonda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9023642Abstract: A bioreactor and method that permits continuous and simultaneous short, moderate, or long term cell culturing of one or more cell types or tissue in a laminar flow configuration is disclosed, where the bioreactor supports at least two laminar flow zones, which are isolated by laminar flow without the need for physical barriers between the zones. The bioreactors of this invention are ideally suited for studying short, moderate and long term studies of cell cultures and the response of cell cultures to one or more stressors such as pharmaceuticals, hypoxia, pathogens, or any other stressor. The bioreactors of this invention are also ideally suited for short, moderate or long term cell culturing with periodic cell harvesting and/or medium processing for secreted cellular components.Type: GrantFiled: July 6, 2007Date of Patent: May 5, 2015Assignee: The University of Houston SystemInventors: Stanley J. Kleis, Sandra K. Geffert, Steve R. Gonda
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Patent number: 8580546Abstract: A method for fabricating a micro-organ device comprises providing a microscale support having one or more microfluidic channels and one or more micro-chambers for housing a micro-organ and printing a micro-organ on the microscale support using a cell suspension in a syringe controlled by a computer-aided tissue engineering system, wherein the cell suspension comprises cells suspended in a solution containing a material that functions as a three-dimensional scaffold. The printing is performed with the computer-aided tissue engineering system according to a particular pattern. The micro-organ device comprises at least one micro-chamber each housing a micro-organ; and at least one microfluidic channel connected to the micro-chamber, wherein the micro-organ comprises cells arranged in a configuration that includes microscale spacing between portions of the cells to facilitate diffusion exchange between the cells and a medium supplied from the at least one microfluidic channel.Type: GrantFiled: November 29, 2012Date of Patent: November 12, 2013Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Steve R. Gonda, Robert C. Chang, Binil Starly, Christopher Culbertson, Heidi L. Holtorf, Wei Sun, Julia Leslie
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Patent number: 8343740Abstract: A method for fabricating a micro-organ device comprises providing a microscale support having one or more microfluidic channels and one or more micro-chambers for housing a micro-organ and printing a micro-organ on the microscale support using a cell suspension in a syringe controlled by a computer-aided tissue engineering system, wherein the cell suspension comprises cells suspended in a solution containing a material that functions as a three-dimensional scaffold. The printing is performed with the computer-aided tissue engineering system according to a particular pattern. The micro-organ device comprises at least one micro-chamber each housing a micro-organ; and at least one microfluidic channel connected to the micro-chamber, wherein the micro-organ comprises cells arranged in a configuration that includes microscale spacing between portions of the cells to facilitate diffusion exchange between the cells and a medium supplied from the at least one microfluidic channel.Type: GrantFiled: March 28, 2008Date of Patent: January 1, 2013Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Steve R. Gonda, Iris von Gustedt-Gonda, legal representative, Robert C. Chang, Binil Starly, Christopher Culbertson, Heidi L. Holtorf, Wei Sun, Julia Leslie
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Publication number: 20080261288Abstract: A method for fabricating a micro-organ device comprises providing a microscale support having one or more microfluidic channels and one or more micro-chambers for housing a micro-organ and printing a micro-organ on the microscale support using a cell suspension in a syringe controlled by a computer-aided tissue engineering system, wherein the cell suspension comprises cells suspended in a solution containing a material that functions as a three-dimensional scaffold. The printing is performed with the computer-aided tissue engineering system according to a particular pattern. The micro-organ device comprises at least one micro-chamber each housing a micro-organ; and at least one microfluidic channel connected to the micro-chamber, wherein the micro-organ comprises cells arranged in a configuration that includes microscale spacing between portions of the cells to facilitate diffusion exchange between the cells and a medium supplied from the at least one microfluidic channel.Type: ApplicationFiled: March 28, 2008Publication date: October 23, 2008Inventors: Steve R. Gonda, Iris von Gustedt-Gonda, Robert C. Chang, Binil Starly, Christopher Culbertson, Heidi L. Holtorf, Wie Sun, Julia Leslie
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Patent number: 7122071Abstract: A gas-liquid separator uses a helical passageway to impart a spiral motion to a fluid passing therethrough. The centrifugal force generated by the spiraling motion urges the liquid component of the fluid radially outward which forces the gas component radially inward. The gas component is then separated through a gas-permeable, liquid-impervious membrane and discharged through a central passageway. A filter material captures target substances contained in the fluid.Type: GrantFiled: September 25, 2002Date of Patent: October 17, 2006Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Steve R. Gonda, Yow-Min D. Tsao, Wenshan Lee
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Patent number: 6863712Abstract: A gas-liquid separator uses a helical passageway to impart a spiral motion to a fluid passing therethrough. The centrifugal fore generated by the spiraling motion urges the liquid component of the fluid radially outward which forces the gas component radially inward. The gas component is then filtered through a gas-permeable, liquid-impervious membrane and discharged through a central passageway.Type: GrantFiled: September 25, 2002Date of Patent: March 8, 2005Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Steve R. Gonda, Yow-Min D. Tsao, Wenshan Lee