Patents by Inventor Steve Schoonooghe

Steve Schoonooghe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Serum albumin binding agents
    Patent number: 11155607
    Abstract: The present invention relates to polypeptides comprising an immunoglobulin variable domain, binding with high affinity to serum albumin for increasing the half-life of therapeutic agents and compositions, in particular for therapeutic agents comprising multispecific immunoglobulin variable domains. Also provided herein are methods for the production of polypeptides comprising serum albumin binding immunoglobulin variable domains of the present invention.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: October 26, 2021
    Assignee: VIB VZW
    Inventors: Gholamreza Hassanzadeh Ghassabeh, Steve Schoonooghe, Erik Depla
  • SERUM ALBUMIN BINDING AGENTS
    Publication number: 20200255504
    Abstract: The present invention relates to polypeptides comprising an immunoglobulin variable domain, binding with high affinity to serum albumin for increasing the half-life of therapeutic agents and compositions, in particular for therapeutic agents comprising multispecific immunoglobulin variable domains. Also provided herein are methods for the production of polypeptides comprising serum albumin binding immunoglobulin variable domains of the present invention.
    Type: Application
    Filed: July 17, 2018
    Publication date: August 13, 2020
    Inventors: Gholamreza Hassanzadeh Ghassabeh, Steve Schoonooghe, Erik Depla
  • Targeting and in vivo imaging of tumor-associated macrophages
    Patent number: 9913920
    Abstract: The disclosure relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: March 13, 2018
    Assignees: VIB VZW, Vrije Universiteit Brussel
    Inventors: Kiavash Movahedi, Damya Laoui, Steve Schoonooghe, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter, Nick Devoogdt, Tony Lahoutte
  • Method of imaging a cardiovascular disease with an anti-macrophage mannose receptor immunoglobulin single variable domain
    Patent number: 9617339
    Abstract: The disclosure relates to the field of cardiovascular diseases. In particular, immunoglobulin single variable domains directed against macrophage mannose receptor (MMR) are provided that can be used in the diagnosis, prognosis and/or monitoring of cardiovascular diseases or as therapeutics. Also, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are useful at different stages of cardiovascular diseases, including post-infarction cardiovascular events. Further, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are particularly useful for the in vivo targeting and/or imaging of vulnerable atherosclerotic plaques.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: April 11, 2017
    Assignees: VIB VZW, Vrije Universiteit Brussel
    Inventors: Patrick De Baetselier, Geert Raes, Steve Schoonooghe, Jens De Vos, Tony Lahoutte, Nick Devoogdt, Sophie Hernot, Gezim Bala, Simon Tierens
  • Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages
    Patent number: 9556273
    Abstract: The disclosure relates to immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) and their uses in the field of oncology. More specifically, it concerns immunoglobulin single variable domains, including single-domain antibodies (sdAbs), against human MMR and their use in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 31, 2017
    Assignees: VIB VZW, Vrije Universiteit Brussel
    Inventors: Jo Van Ginderachter, Patrick De Baetselier, Nick Devoogdt, Tony Lahoutte, Damya Laoui, Kiavash Movahedi, Geert Raes, Steve Schoonooghe
  • ANTI-MACROPHAGE MANNOSE RECEPTOR SINGLE VARIABLE DOMAINS FOR USE IN CARDIOVASCULAR DISEASES
    Publication number: 20160024213
    Abstract: The disclosure relates to the field of cardiovascular diseases. In particular, immunoglobulin single variable domains directed against macrophage mannose receptor (MMR) are provided that can be used in the diagnosis, prognosis and/or monitoring of cardiovascular diseases or as therapeutics. Also, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are useful at different stages of cardiovascular diseases, including post-infarction cardiovascular events. Further, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are particularly useful for the in vivo targeting and/or imaging of vulnerable atherosclerotic plaques.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 28, 2016
    Inventors: Patrick De Baetselier, Geert Raes, Steve Schoonooghe, Jens De Vos, Tony Lahoutte, Nick Devoogdt, Sophie Hernot, Gezim Bala, Simon Tierens
  • TARGETING AND IN VIVO IMAGING OF TUMOR-ASSOCIATED MACROPHAGES
    Publication number: 20150335770
    Abstract: The disclosure relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
    Type: Application
    Filed: August 6, 2015
    Publication date: November 26, 2015
    Inventors: Kiavash Movahedi, Damya Laoui, Steve Schoonooghe, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter, Nick Devoogdt, Tony Lahoutte
  • Targeting and in vivo imaging of tumor-associated macrophages
    Patent number: 9101674
    Abstract: The invention relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: August 11, 2015
    Assignees: VIB VZW, Vrije Universiteit Brussel
    Inventors: Kiavash Movahedi, Damya Laoui, Steve Schoonooghe, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter, Nick Devoogdt, Tony Lahoutte
  • ANTI-MACROPHAGE MANNOSE RECEPTOR SINGLE VARIABLE DOMAINS FOR TARGETING AND IN VIVO IMAGING OF TUMOR-ASSOCIATED MACROPHAGES
    Publication number: 20150093336
    Abstract: The disclosure relates to immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) and their uses in the field of oncology. More specifically, it concerns immunoglobulin single variable domains, including single-domain antibodies (sdAbs), against human MMR and their use in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.
    Type: Application
    Filed: March 15, 2013
    Publication date: April 2, 2015
    Inventors: Jo Van Ginderachter, Patrick De Baetselier, Nick Devoogdt, Tony Lahoutte, Damya Laoui, Kiavash Movahedi, Geert Raes, Steve Schoonooghe
  • TARGETING AND IN VIVO IMAGING OF TUMOR-ASSOCIATED MACROPHAGES
    Publication number: 20120301394
    Abstract: The invention relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
    Type: Application
    Filed: May 24, 2012
    Publication date: November 29, 2012
    Applicant: VIB VZW
    Inventors: Kiavash Movahedi, Damya Laoui, Steve Schoonooghe, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter, Nick Devoogdt, Tony Lahoutte
  • Selective targeting of intratumoral cells
    Publication number: 20110262348
    Abstract: The present invention relates to the field of tumor growth and biology. The invention relates to activities and characteristics of tumor-associated macrophages, and uses of such for the diagnosis and treatment of cancer and tumor growth.
    Type: Application
    Filed: March 29, 2011
    Publication date: October 27, 2011
    Applicants: Vrije Universiteit Brussel, VIB VZW
    Inventors: Kiavash Movahedi, Damya Laoui, Steve Schoonooghe, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter, Nick Devoogdt, Tony Lahoutte