Patents by Inventor Steve Shak

Steve Shak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene expression profiling in biopsied tumor tissues
    Patent number: 10241114
    Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: March 26, 2019
    Assignee: Genomic Health, Inc.
    Inventors: Joffre B. Baker, Maureen T. Cronin, Michael C. Kiefer, Steve Shak, Michael Graham Walker
  • Gene expression markers for breast cancer prognosis
    Patent number: 8741605
    Abstract: The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: June 3, 2014
    Assignee: Genomic Health, Inc.
    Inventors: Melody A. Cobleigh, Steve Shak, Joffre B. Baker, Maureen T. Cronin
  • Gene expression profile algorithm and test for determining prognosis of prostate cancer
    Patent number: 8725426
    Abstract: The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes, or their co-expressed genes, from a biological sample obtained from a prostate cancer patient. The genes may be grouped into functional gene subsets for calculating a quantitative score useful to predict a likelihood of a clinical outcome for a prostate cancer patient.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: May 13, 2014
    Assignee: Genomic Health, Inc.
    Inventors: Steve Shak, Mark Lee, William Novotny, Tara Maddala, Michael Crager, Diana Cherbavaz, Robert J. Pelham, Carl L. Millward, Dejan Knezevic
  • Gene Expression Markers for Breast Cancer Prognosis
    Publication number: 20120225433
    Abstract: The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
    Type: Application
    Filed: May 16, 2012
    Publication date: September 6, 2012
    Inventors: Melody A. Cobleigh, Steve Shak, Joffre B. Baker, Maureen T. Cronin
  • GENE EXPRESSION PROFILING OF EGFR POSITIVE CANCER
    Publication number: 20120178644
    Abstract: The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
    Type: Application
    Filed: January 10, 2012
    Publication date: July 12, 2012
    Inventors: Joffre B. Baker, Maureen T. Cronin, Steve Shak, Jose Baselga
  • Gene expression markers for breast cancer prognosis
    Patent number: 8206919
    Abstract: The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: June 26, 2012
    Assignee: Genomic Health, Inc.
    Inventors: Melody A. Cobleigh, Steve Shak, Joffre B. Baker, Maureen T. Cronin
  • Gene Expression Markers for Breast Cancer Prognosis
    Publication number: 20110312532
    Abstract: The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
    Type: Application
    Filed: August 30, 2011
    Publication date: December 22, 2011
    Inventors: Melody A. Cobleigh, Steve Shak, Joffre B. Baker, Maureen T. Cronin
  • Gene expression profiling in biopsied tumor tissues
    Patent number: 8071286
    Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: December 6, 2011
    Assignee: Genomic Health, Inc.
    Inventors: Joffre B. Baker, Maureen T. Cronin, Michael C. Kiefer, Steve Shak, Michael Graham Walker
  • Gene Expression Profiling of EGFR Positive Cancer
    Publication number: 20110245102
    Abstract: The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
    Type: Application
    Filed: June 1, 2011
    Publication date: October 6, 2011
    Inventors: Joffre B. Baker, Maureen T. Cronin, Steve Shak, Jose Baselga
  • Gene expression profiling of EGFR positive cancer
    Patent number: 8008003
    Abstract: The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: August 30, 2011
    Assignee: Genomic Health, Inc.
    Inventors: Joffre B. Baker, Maureen T. Cronin, Steve Shak, Jose Baselga
  • Gene expression profiling in biopsied tumor tissues
    Patent number: 7858304
    Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: December 28, 2010
    Assignee: Genomic Health, Inc.
    Inventors: Joffre B. Baker, Maureen T. Cronin, Michael C. Kiefer, Steve Shak, Michael Graham Walker
  • Gene expression profiling in biopsied tumor tissues
    Patent number: 7838224
    Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: November 23, 2010
    Assignee: Genomic Health, Inc.
    Inventors: Joffre B. Baker, Maureen T. Cronin, Michael C. Kiefer, Steve Shak, Michael Graham Walker
  • Gene Expression Markers for Breast Cancer Prognosis
    Publication number: 20100222229
    Abstract: The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
    Type: Application
    Filed: June 4, 2009
    Publication date: September 2, 2010
    Inventors: Melody A. Cobleigh, Steve Shak, Joffre B. Baker, Maureen T. Cronin
  • Gene Expression Profiling in Biopsied Tumor Tissues
    Publication number: 20100209920
    Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
    Type: Application
    Filed: November 10, 2009
    Publication date: August 19, 2010
    Inventors: Joffre B. Baker, Maureen T. Cronin, Michael C. Kiefer, Steve Shak, Michael Graham Walker
  • Method for Determining the Likelihood of Response to HER2 Inhibitors
    Publication number: 20100151463
    Abstract: The present disclosure provides methods for determining the HER2 Status of a cancer tumor sample.
    Type: Application
    Filed: September 4, 2009
    Publication date: June 17, 2010
    Inventors: Frederick L. Baehner, Drew Watson, Tara Maddala, Steve Shak, Robert Gray, Joseph Sparano
  • TESTS TO PREDICT RESPONSIVENESS OF CANCER PATIENTS TO CHEMOTHERAPY TREATMENT OPTIONS
    Publication number: 20090311702
    Abstract: The present disclosure provides methods and compositions to facilitate prediction of the likelihood of responsiveness of cancer patients to treatment including a taxane and/or a cyclophosphamide.
    Type: Application
    Filed: May 12, 2009
    Publication date: December 17, 2009
    Inventors: STEVE SHAK, JOFFRE B. BAKER, CARL YOSHIZAWA, JOSEPH SPARANO, ROBERT GRAY
  • Gene expression markers for breast cancer prognosis
    Patent number: 7569345
    Abstract: The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
    Type: Grant
    Filed: January 14, 2004
    Date of Patent: August 4, 2009
    Assignees: Genomic Health, Inc., Rush-Presbyterian-St. Lukes Medical Center
    Inventors: Melody A. Cobleigh, Steve Shak, Joffre B. Baker, Maureen T. Cronin
  • Gene Expression Profiling in Biopsied Tumor Tissues
    Publication number: 20080182255
    Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 31, 2008
    Inventors: Joffre B. Baker, Maureen T. Cronin, Michael C. Kiefer, Steve Shak, Michael Graham Walker
  • Gene expression profiling in biopsied tumor tissues
    Publication number: 20070141588
    Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
    Type: Application
    Filed: June 9, 2006
    Publication date: June 21, 2007
    Inventors: Joffre Baker, Maureen Cronin, Michael Kiefer, Steve Shak, Michael Walker
  • Gene expression profiling in biopsied tumor tissues
    Publication number: 20070141587
    Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
    Type: Application
    Filed: June 9, 2006
    Publication date: June 21, 2007
    Inventors: Joffre Baker, Maureen Cronin, Michael Kiefer, Steve Shak, Michael Walker