Abstract: The present invention encompasses compounds of formula (I) wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V, W, L and E have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: An ultrasound imaging system includes an ultrasound probe comprising an ultrasound transducer array. The ultrasound imaging system further includes a processor circuit configured for communication with the ultrasound probe via a first conductive pathway and a second conductive pathway. The ultrasound imaging system further includes a first connector and a second connector configured to be selectively engaged to establish the communication between the ultrasound probe and the processor circuit. The processor circuit is configured to detect an electrical conductance along the first conductive pathway. The processor circuit is further configured to transmit data to the ultrasound probe via the second conductive pathway only after detecting the electrical conductance along the first conductive pathway.

Abstract: Embodiments provide apparatus, systems, and methods for communicating analyte data and/or related information. In a first aspect, the apparatus includes a transmitter/receiver unit which is configurable as either a transmitter or a receiver. The transmitter/receiver unit may be coupled to an on-body sensor and may be configured as a transmitter, or may be coupled to a management unit and may be configured as a receiver as part of a continuous analyte monitoring system. Analyte data communication systems and methods are provided, as are other aspects.

Abstract: In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor has a base, a first electrode and a second electrode wherein a thermocouple portion is provided integral with the second electrode thereby enabling on-sensor temperature measurement capability. In some embodiments, two and only two electrical contact engagement portions are provided thereby simplifying electrical contact. Manufacturing methods and systems utilizing the analyte sensors are provided, as are numerous other aspects.

Abstract: A portable data-management system may be easily employed with multiple processing devices by eliminating the need to pre-install additional programs, agents, device drivers, or other software components on the hosts. A portable storage device contains software for a data-management application, which receives and processes test data from a meter that measures an analyte. The portable device may employ an interface protocol that makes the portable device immediately compatible with different operating systems and hardware configurations. Once the portable device is connected to the host, the data-management application can be automatically launched. The convenience and portability of a data-management system may be enhanced by integrating advanced data processing and display features with the portable device. The users may access some advanced presentations of health data without having to launch the data-management application on a separate host.

Abstract: Methods and systems accurately determine an analyte concentration in a fluid sample. In an example embodiment, a receiving port receives a test sensor. The test sensor includes a fluid-receiving area for receiving a fluid sample. The fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the fluid sample. The test sensor has a test-sensor temperature and the reagent has a reagent temperature. A measurement system measures the reaction between the reagent and the analyte. A temperature-measuring system measures the test sensor temperature when the test sensor is received into the receiving port. A concentration of the analyte in the fluid sample is determined according to the measurement of the reaction and the measurement of the test sensor temperature. A diagnostic system determines an accuracy of the temperature-measuring system. The calculation of the analyte concentration may be adjusted according to the accuracy of temperature-measuring system.

Abstract: The present disclosure describes a system and method for microfluidic separation. More particularly, the disclosure describes a system and method for the purification of a fluid by the removal of undesired particles. The device includes microfluidic separation channels that include multiple outlets. The device also includes isolation slots positioned between each of the microfluidic separation channels. The device's base includes multiple acoustic transducers which in some implementations are configured to protrude into the isolation slots. The acoustic transducers are configured to generate aggregation axes within the separation channels, which are used to separate out undesired particles.

Abstract: Wearable heat flux devices are disclosed that can detect heat flux based on evaporative cooling for determining a core body temperature of a user, and that can heat or cool a surface of a user for reaching a steady-state heat flux to determine the core body temperature of the user. Exemplary heat flux devices can include a heat flux sensor and a wicking layer. The heat flux sensor can be configured to detect heat flux at a location on a user. The wicking layer can be configured to absorb moisture at the location and to transport the moisture above the heat flux sensor. The heat flux subsequently detected by the heat flux sensor includes the evaporative cooling from the evaporation of the moisture.

Abstract: The present disclosure describes a system and method for microfluidic separation. More particularly, the disclosure describes a system and method for the purification of a fluid by the removal of undesired particles. The device includes microfluidic separation channels that include multiple outlets. The device also includes isolation slots positioned between each of the microfluidic separation channels. The device's base includes multiple acoustic transducers which in some implementations are configured to protrude into the isolation slots. The acoustic transducers are configured to generate aggregation axes within the separation channels, which are used to separate out undesired particles.

Abstract: An on-body sensor system includes a hub configured to be attached to a surface of a user. The hub being further configured to transmit electrical power and/or data signals into the surface and to receive response data signals from the surface. The system further including at least one sensor node configured to be attached to the surface. The sensor node being further configured to receive the electrical power and data signals from the hub through the surface and to transmit the response data signals into the surface. The electrical power from the hub can power the sensor node and cause or enable the at least one sensor node to generate sensor information that is transmitted back to the hub within the response data signals.

Abstract: Systems, methods, and apparatuses for detecting fluid ingress in ultrasound probes are disclosed. A fluid ingress may be detected by a change in resistance, capacitance, and/or current of a fluid ingress detector of a fluid ingress detection assembly. A fluid ingress detector that includes a soluble material is disclosed. A fluid ingress detector that includes a galvanic sensor is disclosed. The fluid ingress detector may provide a signal indicating a fluid ingress to an ultrasound imaging system and/or a maintenance diagnostic system.

Abstract: A portable data-management system may be easily employed with multiple processing devices by eliminating the need to pre-install additional programs, agents, device drivers, or other software components on the hosts. A portable storage device contains software for a data-management application, which receives and processes test data from a meter that measures an analyte. The portable device may employ an interface protocol that makes the portable device immediately compatible with different operating systems and hardware configurations. Once the portable device is connected to the host, the data-management application can be automatically launched. The convenience and portability of a data-management system may be enhanced by integrating advanced data processing and display features with the portable device. The users may access some advanced presentations of health data without having to launch the data-management application on a separate host.

Abstract: An apparatus for performing a medical procedure comprises a sensor adapted to convert an ultrasonic signal incident thereon into an electrical signal. The sensor comprises a lower electrode and an upper electrode, and the upper electrode is adapted to transmit the electrical signal to an electrode of an ultrasound imaging probe.

Abstract: In some aspects, a device is provided having a member with a region of enhanced electrochemical activity. In one aspect, a sensor of enhanced electrochemical activity is provided for detecting an analyte concentration level in a bio-fluid sample. The sensor may include a sensor member of a semiconductor material wherein the sensor member has a surface region of enhanced electrochemical activity. In other aspects, the member may be made of semiconducting foam having a surface region of enhanced electrochemical activity. In some embodiments, the region may be thermally-induced. Manufacturing methods and apparatus are also provided, as are numerous other aspects.

Abstract: A moisture sensor includes a pair of electrode plates separated by a moisture absorbent material that forms the dielectric of a capacitive sensor. As the absorbent dielectric material absorbs moisture, such as perspiration, the capacitance of the sensor changes reflecting a quantitative measure of perspiration absorbed. The sensor can be stabilized by capacitively coupling the dielectric material to the skin of the user to improve sensor stability and noise rejection. The sensor can include a capacitive sensing integrated circuit that measures the capacitance of the sensor in close proximity to the electrodes to limit the introduction of noise.

Abstract: An analyte sensor is provided that comprises a substrate which includes a semiconductor material. Embodiments may include a core of a conductive material, and a cladding of a semiconductor material, in which the cladding may form at least a portion of a conducting path for a working electrode of the analyte sensor. Method of manufacturing and using the analyte sensor are described, as are numerous other aspects.

Abstract: Methods and systems accurately determine an analyte concentration in a fluid sample. In an example embodiment, a receiving port receives a test sensor. The test sensor includes a fluid-receiving area for receiving a fluid sample. The fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the fluid sample. The test sensor has a test-sensor temperature and the reagent has a reagent temperature. A measurement system measures the reaction between the reagent and the analyte. A temperature-measuring system measures the test sensor temperature when the test sensor is received into the receiving port. A concentration of the analyte in the fluid sample is determined according to the measurement of the reaction and the measurement of the test sensor temperature. A diagnostic system determines an accuracy of the temperature-measuring system. The calculation of the analyte concentration may be adjusted according to the accuracy of temperature-measuring system.

Abstract: Embodiments provide apparatus, systems, and methods for communicating analyte data and/or related information. In a first aspect, the apparatus includes a transmitter/receiver unit which is configurable as either a transmitter or a receiver. The transmitter/receiver unit may be coupled to an on-body sensor and may be configured as a transmitter, or may be coupled to a management unit and may be configured as a receiver as part of a continuous analyte monitoring system. Analyte data communication systems and methods are provided, as are other aspects.

Abstract: An on-body sensor system includes a hub configured to be attached to a surface of a user. The hub being further configured to transmit electrical power and/or data signals into the surface and to receive response data signals from the surface. The system further including at least one sensor node configured to be attached to the surface. The sensor node being further configured to receive the electrical power and data signals from the hub through the surface and to transmit the response data signals into the surface. The electrical power from the hub can power the sensor node and cause or enable the at least one sensor node to generate sensor information that is transmitted back to the hub within the response data signals.

Abstract: An architecture allows individual system components to be developed and tested individually, i.e., as distinct modules, and to be subsequently combined through standardized electrical and communication interfaces. Any combination of these modules can be implemented to form different products that provide any number of functions, such as an integrated system for monitoring a health condition and/or delivering a medication. The architecture also provides an approach for dynamically updating the product and offering its users the latest generation of technology even after the users have already purchased the product. In particular, the embodiments employ the communication interfaces to also provide connection to a remote network that can update or upgrade the product's software when the product is out in the field.