Abstract: Systems and methods for providing structural support and reinforcement for surfaces, materials and devices, including drywall. A structural support and reinforcement system includes one or more structural support and reinforcement panels located behind one or more surfaces, materials and/or devices. In one embodiment, the structural support and reinforcement panel is placed between the structural studs and a desired section of drywall during original construction. In another embodiment, the structural support and reinforcement panel is placed between the structural studs and the desired section of drywall during repair or renovation. A user can apply an external load to the drywall by way of an attachment device, such as a screw, which extends through the drywall and the structural support and reinforcement panel. By attaching the external load through the drywall and the structural support and reinforcement panel the load bearing capacity of the drywall is enhanced.