Abstract: Described herein are methods of optimizing an interactive media (e.g., a videogame) based on a brain activity criterion, as well as interactive media optimized or incorporating these methods. Brain activity may be measured using imaging techniques, such as an fMRI image of neural activity taken while a subject is using the technology. The optimization may be used to help the interactive media evoke desired behaviors or attitudes in subjects who have used the interactive media. For example, the interactive media described herein may be optimized to help facilitate behaviors or attitudes that are conducive to medical therapies, including compliance with medical treatments.