Abstract: The present invention provides injectable formulations of (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol and hydrates thereof and methods for treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders.

Abstract: The present invention provides injectable formulations of (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol and hydrates thereof and methods for treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders.

Abstract: The present invention provides injectable formulations of (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol and hydrates thereof and methods for treating disorders in which DOT 1-mediated protein methylation plays a part, such as cancer and neurological disorders.

Abstract: A remote motor vehicle signal indicator system comprising a transmitter coupled to a vehicle indication signal drive line. The transmitter wirelessly transmits a receiver activation signal corresponding to a vehicle indication signal of the vehicle indication signal drive line. Optionally, the transmitter may be configured to bypass transmission of a brake signal to a remote vehicle signal indicator in order to conserve power at the remote vehicle signal indicator. The vehicle indication signal is selected may comprise a turn signal, a brake signal, a reverse gear signal, and a hazard signal or any other signal displayable on a vehicle. The system also includes a remote vehicle signal indicator coupled to a surface outside of the vehicle and includes a signal indicator display.

Abstract: A remote motor vehicle signal indicator system comprising a transmitter coupled to a vehicle indication signal drive line. The transmitter wirelessly transmits a receiver activation signal corresponding to a vehicle indication signal of the vehicle indication signal drive line. Optionally, the transmitter may be configured to bypass transmission of a brake signal to a remote vehicle signal indicator in order to conserve power at the remote vehicle signal indicator. The vehicle indication signal is selected may comprise a turn signal, a brake signal, a reverse gear signal, and a hazard signal or any other signal displayable on a vehicle. The system also includes a remote vehicle signal indicator coupled to a surface outside of the vehicle and includes a signal indicator display.